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Potassium Channel

Potassium Channel

Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.

Potassium Channel related products

Structure Cat No. Product Name CAS No. Product Description
ML133 HCl V0210 ML133 HCl 1222781-70-5 ML133 HCl, the hydrochloride salt ofML-133,is a novel, potent and selective inhibitor of the inward-rectifier potassium channel 2 (Kir2) identified from a high-throughput screening (HTS) of more than 300,000 small molecules.
ML213 V3227 ML213 489402-47-3 ML213 (formerly known as CID-3111211) is a potent and selective activator/opener ofKv7.2(KCNQ2) andKv7.4 (KCNQ4)channels which enhances Kv7.2 and Kv7.4 channels withEC50of 230 and 510 nM, respectively.
ML277 V4022 ML277 1401242-74-7 ML277 (formerly known as CID53347902) is a novel, potent and selective activator of the K(v)7.1 (KCNQ1) potassium channel with EC50 of 270 nM.
ML297 V4034 ML297 1443246-62-5 ML297 isa truly potent and selective GIRK channel agonist with IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively.
ML335 V3219 ML335 825658-06-8 ML335 (ML-335) is a potent and selective activator of TREK-1/-2and an agonist for OPRM1-OPRD1 (OPRM1: opioid receptor mu 1; OPRD1: delta opioid receptor) heterdimerization.
ML365 V4002 ML365 947914-18-3 ML365 is a potent, novel and selective small molecule inhibitor of the TASK1(KCNK3, a two-pore domain potassium channel).
ML402 V4016 ML402 298684-44-3 ML402 (ML-402) is a potent and selective activator of TREK-1/-2and an agonist for OPRM1-OPRD1 (OPRM1: opioid receptor mu 1; OPRD1: delta opioid receptor) heterdimerization.
ML67-33 V73592 ML67-33 1443290-89-8 ML67-33 is a selective activator of temperature- and mechanically-sensitive K2P channels.
Naminidil V3523 Naminidil 220641-11-2 Naminidil (BMS 234303-01) is a novel and potentcyanoguanidineKATPopener (ATP-Sensitive Potassium Channel Vasodilator).
Nateglinide (Starlix; A4166) V0198 Nateglinide (Starlix; A4166) 105816-04-4 Nateglinide (formerly A-4166; trade names: Fastic, Starlix), a meglitinide analog,is a potent and orally bioavailableantihyperglycemic medication used for treating type 2 diabetes [non-insulin-dependent diabetes mellitus (NIDDM)].
Nicorandil (SG-75) V1676 Nicorandil (SG-75) 65141-46-0 Nicorandil (formerly RP46417; SG-75; SG75; RP-46417; Dancor and Adancor) is a potassium channel activator that has been approved as a vasodilatory drug to treat angina.
Nicorandil-d4 (Nicorandil d4) V73620 Nicorandil-d4 (Nicorandil d4) 1132681-23-2 Nicorandil-d4 is the deuterium labelled form of Nicorandil.
Nifekalant hydrochloride (MS-551) V41791 Nifekalant hydrochloride (MS-551) 130656-51-8 Nifekalant hydrochloride (MS-551) is an IKr potassium channel blocker belonging to the class III antiarrhythmic agentwith an IC50 of 10 µM.
Nigericin sodium V4873 Nigericin sodium 28643-80-3 Nigericin sodium, the sodium salt of nigericin which is an antibiotic isolated fromStreptomyces hygroscopicus,is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria.
Noxiustoxin V73657 Noxiustoxin 85205-49-8 Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius that blocks voltage-dependent potassium channels (Kv1.3, IC50=360 nM) and calcium-activated potassium channels.
NPBA V85801 NPBA 524033-40-7
NS-11021 V11738 NS-11021 956014-19-0 NS-11021 is a novel, potent and selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1).
NS-1643 V2831 NS-1643 448895-37-2 NS1643 is a novel and potent human ether-a-go-go related gene (hERG) KV11 channel activator with EC50 of 10.5 μM.
NS-5806 V21754 NS-5806 426834-69-7 NS-5806 (NS5806) is a novel and potent potassium currentKV4.3 channel activator whichincreases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM.
NS1619 V2809 NS1619 153587-01-0 NS-1619 is a selective activator of the large conductance Ca2+-activated K+-channel (BKCa, KCa1.1).
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