Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73591 | NS19504 | 327062-46-4 | NS19504 is a Ca2+-activated K+ channel (BK channel) activator (EC50=11.0 µM) that has a relaxing effect on spontaneous phasic contractions of bladder smooth muscle. |
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V26675 | NS309 | 18711-16-5 | NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). |
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V26676 | NS3623 | 343630-41-1 | NS3623 (NS-3623) is a novel and potent (hERG) and KV4.3 channel activator withantiarrhythmic effects. |
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V2816 | NS6180 | 353262-04-1 | NS6180 is a novel potent and selective KCa3.1 channel inhibitor with IC50 of 9 nM. |
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V73654 | OSK-1 | 183815-75-0 | OSK-1 is an effective Kv channel blocker, with IC50s of 0.6 nM, 5.4 nM and 0.014 nM for Kv1.1, Kv1.2 and Kv1.3 respectively. |
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V70540 | Oxybutynin-d11 chloride (oxybutynin d11 (chloride)) | 1185151-95-4 | Oxybutynin-d11 (chloride) is the deuterated form of Oxybutynin chloride. |
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V73630 | P-CAB agent 2 | 1978371-23-1 | P-CAB agent 2 is a potent and orally bioactive potassium-competitive acid blocker and gastric acid secretion inhibitor. |
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V73610 | P-CAB agent 2 hydrochloride | 2209911-80-6 | P-CAB agent 2 HCl is a potent and orally bioactive potassium-competitive acid blocker and gastric acid secretion inhibitor. |
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V18696 | PA-6 | 500715-03-7 | PA-6 is a selective and potent IK1 (inward rectifier potassium current) inhibitor that terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. |
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V73612 | Pandinotoxin Kα | 185529-64-0 | Pandininotoxin Kα is extracted from the venom of Pandinus imperator and is an inhibitor (blocker/antagonist) of type A potassium channel (potassium channel). |
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V73626 | Patiromer | 1208912-84-8 | Patiromer is an orally bioactive and potent hyperkalemia inhibitor, potassium binder. |
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V73625 | PE 22-28 | 1801959-12-5 | PE 22-28 is a TREK-1 inhibitor (antagonist) with IC50 of 0.12 nM. |
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V73638 | Phrixotoxin 2 | 741738-57-8 | Phrixotoxin 2 is a selective KV4.2 and KV4.3 channel blocker. |
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V73632 | Phrixotoxin-1 | 221872-97-5 | Phrixotoxin 1 is derived from the venom of the wolf spider Phrixotrichus auratus and is a specific peptide inhibitor of the Kv4 potassium channel. |
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V85974 | Phrixotoxin-1 TFA | ||
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V29082 | Pinacidil monohydrate | 85371-64-8 | Pinacidil (P-1134) monohydrate, an anti-hypertensive (blood pressure lowering) drug, is a potassium channel activator. |
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V1686 | Probenecid (Benemid) | 57-66-9 | Probenecid (Benemid; Probecid;Benecid; Benuryl; Probenecid Martec; Probalan)is an OAT (organic anion transport) inhibitor which has been used as a medication to increase uric acid excretion in the urine. |
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V8951 | Psora-4 | 724709-68-6 | Psora-4 is a novel, potent and selective small-molecule inhibitor ofvoltage-gated potassium channels - Kv1.3 with EC50of 3 nM. |
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V7338 | Quinine | 130-95-0 | Quinine is a naturally occuring anti-malaria agent which acts as apotassium channelinhibitor with anIC50of 169 μM, also has antipyretic (fever-reducing), analgesic (painkilling), anti-inflammatory properties and a bitter taste. |
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V1675 | Repaglinide (AG-EE 623ZW) | 135062-02-1 | Repaglinide (AG-EE388 ZW; AG-EE-623 ZW, Prandin, GlucoNorm, Surepost, NovoNorm)is a potent and short-acting potassium channel blocker with antidiabetic activity. |
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