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Fungal

Fungal

A drug known as an antifungal agent selectively removes fungal pathogens from a host with little harm to the host. Classes: 1. Polyene antifungal medications: Amphotericin, nystatin, and pimaricin interact with the cell membrane's sterols (ergosterol in fungi, cholesterol in people) to create channels that allow small molecules to escape the inside of the fungal cell and enter the surrounding environment. 2. Azole antifungal medications: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes, particularly C14-demethylase, which are involved in the biosynthesis of ergosterol, a substance necessary for the structure and operation of fungal cell membranes. 3. Morpholine and allylamine antifungal medications: Squalene epoxidase is the enzyme that lylamines (naftifine, terbinafine) inhibit.At a later stage, the morpholine drug amorolfine inhibits the same pathway. 4. Antifungal Antimetabolite Drugs: Because 5-fluorocytosine is converted to 5-fluorouracil intracytoplasmically, it inhibits the synthesis of both DNA and RNA.

Fungal related products

Structure Cat No. Product Name CAS No. Product Description
(10E,12E)-9-Oxo-10,12-octadecadienoic acid V88758 (10E,12E)-9-Oxo-10,12-octadecadienoic acid 54232-58-5 (10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist isolated from the basidiomycete Gomphus floccosus.
(4S)-(+)-Ascochin V91048 (4S)-(+)-Ascochin 935699-58-4 (4S)-(+)-Ascochin is an antifungal agent that inhibits Microbotryum violaceum, Phytophthora infestans and Septoria tritici.
(E)-4-Methyl-5-styrylbenzene-1,3-diol V90886 (E)-4-Methyl-5-styrylbenzene-1,3-diol 2407559-34-4 (E)-4-Methyl-5-styrylbenzene-1,3-diol (Compound III) is an antifungal agent extracted from Dracaena cochinchinensis (Lour.) SC Chen.
13-Hydroxy-9-octadecenoic acid V97796 13-Hydroxy-9-octadecenoic acid 324575-43-1 13-Hydroxy-9-octadecenoic acid is a hydroxyunsaturated fatty acid (HUFA) with antifungal activity.
14α-Demethylase-IN-1 V94976 14α-Demethylase-IN-1 3026164-55-3 14α-Demethylase-IN-1 (Compound 2e) is a 14α-demethylase inhibitor and can be used as an antifungal agent.
2′-Hydroxychalcone V89726 2′-Hydroxychalcone 1214-47-7 2'-Hydroxychalcone is a hydroxy derivative of chalcone with anticancer activity.
3-GlcA-28-AraRhaxyl-medicagenate V97799 3-GlcA-28-AraRhaxyl-medicagenate 128192-15-4 3-GlcA-28-AraRhaxyl-medicagenate is an insect toxin belonging to the saponin family.
6-Prenylindole V102421 6-Prenylindole 23158-16-9 6-Isopentenyl indole is an antifungal agent that can be isolated from Streptomyces sp.
8-Acetylverrucarin L V91114 8-Acetylverrucarin L 77101-88-3 8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin with antitumor and antibacterial activities.
Acremine I V91076 Acremine I 1110661-29-4 Acremine I is a fungicide and a metabolite of the endophytic fungus Acremonium byssoides.
AEC5 V101746 AEC5 2035042-31-8 AEC5 is a lipopeptide with antifungal activity against Cryptococcus neoformans infection.
Alternariol, methyl ether V101926 Alternariol, methyl ether 26894-49-5 Alternaria methyl ether is a common mycotoxin in spoiled grains, which has mutagenic and carcinogenic effects in vitro.
Amycolatopsin B V91774 Amycolatopsin B 2209112-97-8 Amycolatopsin B (compound 2) is a glycosylated polyketide macrolide with antifungal activity that was isolated from the soil isolate Amycolatopsis sp. MST-108494.
Ansatrienin A V88250 Ansatrienin A 82189-03-5 Ansatrienin A is an antifungal antibiotic isolated from Streptomyces collinus.
Antibacterial agent 67 V51010 Antibacterial agent 67 2488900-01-0 The inhibitory activity of antibacterial agent 67 (IC50 = 0.03 μM) as an enzyme inhibitor of acid dehydrogenase was significantly higher than that of fluorophosphotidol (IC50 = 4.40 μM).
Antibiofilm agent-12 V96709 Antibiofilm agent-12 480452-24-2 Antibiofilm agent-12 (Compound C13) is a carbamate derivative antifungal agent.
Antibiotic WB V91120 Antibiotic WB 247919-66-0 Antibiotic WB is an antibiotic with antifungal activity, which can be isolated from soil fungus strain 38.
Antifungal agent 100 V92168 Antifungal agent 100 2975157-18-5 Antifungal agent 100 (compound 3i) exhibited significant antifungal activity against S. sclerotiorum with an EC50 value of 0.33 mg/L.
Antifungal agent 102 V101649 Antifungal agent 102 Antifungal agent 102 (compound C20) is an antifungal agent against Botrytis cinerea with an EC50 value of 1.23 μg/mL.
Antifungal agent 104 V101675 Antifungal agent 104 Antifungal agent 104 (compound 5e) showed antifungal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, and Botrytis cinerea with EC50 values of 1.52 μg/mL, 0.06 μg/mL, and 15.69 μg/mL, respectively.
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