The ubiquitous Ser/Thr kinases known as casein kinases (CKs) control a variety of cellular processes in eukaryotes, including the phosphorylation of proteins that are targets for degradation by the ubiquitin-proteasome system (UPS). Casein kinase-1 (CK-1) and casein kinase-2 (CK-2) have both been extensively characterized.
Mammals have at least seven different isoforms of CK1 kinases (,, 1-3,, and ), and these enzymes phosphorylate different substrates to participate in a variety of physiological processes including DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis.A highly pleiotropic serine-threonine kinase called casein kinase 2 (CK2) phosphorylated more than 300 proteins, many of which are involved in the regulation of cellular processes like signal transduction, transcriptional control, apoptosis, and the cell cycle.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V55056 | Casein Kinase II Substrate | 95651-74-4 | Casein Kinase II Substrate is a casein kinase II (CK2) peptide substrate that is selectively phosphorylated by CK2. |
|
V55055 | CK1-IN-2 | 1383376-92-8 | CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor (antagonist) with IC50s of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively. |
|
V55058 | CK1-IN-3 | 349438-74-0 | CK1-IN-3 (compound 51) is an AC1 inhibitor (antagonist) with IC50 of 2.22 µM for CK-1δ. |
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V52245 | CK2 inhibitor 2 | 2641079-92-5 | CK2 inhibitor 2 is a specific and orally bioactive CK2 inhibitor (antagonist) with IC50 of 0.66 nM. |
|
V55063 | CK2-IN-4 | 313985-59-0 | CK2-IN-4 (Compound 5) is a protein kinase (CK2) inhibitor (IC50=8.6 µM). |
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V55057 | CK2-IN-6 | 1309835-18-4 | CK2-IN-6 is a potent inhibitor of the protein kinase CK2 and may be utilized in the study of cancer and other kinase-related conditions such as inflammation, pain and certain immune diseases. |
|
V55059 | CK2-IN-7 | 2920559-18-6 | CK2-IN-7 (compound 2) is an inhibitor (blocker/antagonist) of casein kinase CK2. |
|
V84717 | CK2-IN-8 | 442571-27-9 | |
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V55060 | CK2-IN-9 | 1461658-58-1 | CK2-IN-9 is a potent and specific inhibitor of CK2 kinase with IC50 of 3 nM. |
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V69788 | CK2α-IN-1 | 443747-52-2 | CK2α-IN-1 (compound 2) is a selective CK2α inhibitor (IC50=7.0 µM; Ki=1.6 µM), which displays a non-ATP competitive mode of action. |
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V84911 | CSNK2A-IN-1 | ||
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V84725 | CSNK2A-IN-2 | ||
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V85404 | DEG-77 | 3032265-06-5 | |
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V69798 | Ellagic acid (hydrate) | 314041-08-2 | Ellagic acid hydrate is a natural antioxidant and a potent, ATP-competitive CK2 inhibitor (antagonist) with IC50 and Kis of 40 nM and 20 nM respectively. |
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V52646 | Emodin-d4 (Frangula emodin-d4) | 132796-52-2 | Emodin-d4 is the deuterium labelled form of Emodin. |
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V52083 | FPFT-2216 | 2367619-87-0 | FPFT-2216 is a "molecular glue" compound that degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). |
|
V55053 | IQA (CGP-029482) | 391670-48-7 | IQA (CGP-029482) is a potent and specific inhibitor of protein kinase CK2. |
|
V51919 | JNJ-6204 | 2765264-50-2 | JNJ-6204 is a dual (bifunctional) inhibitor of CSNK1D and CSNK1E (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM) and has good brain penetration. |
|
V24087 | LH846 | 639052-78-1 | LH846 is a selective CKIδ inhibitor (antagonist) with IC50 of 290 nM; its inhibitory activity against CKIα and CKIε is relatively weak, with IC50s of 2.5 μM and 1.3 μM respectively. |
|
V5237 | Longdaysin | 1353867-91-0 | Longdaysin is a novel and potent inhibitor of Casein Kinase (CK1α, CK1δ, CDK7) and ERK2 with IC50s of 5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively. |
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