The ubiquitous Ser/Thr kinases known as casein kinases (CKs) control a variety of cellular processes in eukaryotes, including the phosphorylation of proteins that are targets for degradation by the ubiquitin-proteasome system (UPS). Casein kinase-1 (CK-1) and casein kinase-2 (CK-2) have both been extensively characterized.
Mammals have at least seven different isoforms of CK1 kinases (,, 1-3,, and ), and these enzymes phosphorylate different substrates to participate in a variety of physiological processes including DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis.A highly pleiotropic serine-threonine kinase called casein kinase 2 (CK2) phosphorylated more than 300 proteins, many of which are involved in the regulation of cellular processes like signal transduction, transcriptional control, apoptosis, and the cell cycle.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
![]() |
V88607 | CSNK2-IN-1 | CSNK2-IN-1 is a potent and selective CSNK2 inhibitor with IC50 of 1.7 nM and 0.66 nM for CSNK2A1 and CSNK2A2, respectively. | |
![]() |
V84911 | CSNK2A-IN-1 | 3029550-24-8 | |
![]() |
V84725 | CSNK2A-IN-2 | ||
![]() |
V104611 | dCK1α-2 | dCK1α-2 is an oral CK1α molecular glue degrader that can target p53 pathway-related targets. | |
![]() |
V85404 | DEG-77 | 3032265-06-5 | |
![]() |
V69798 | Ellagic acid (hydrate) | 314041-08-2 | Ellagic acid hydrate is a natural antioxidant and a potent, ATP-competitive CK2 inhibitor (antagonist) with IC50 and Kis of 40 nM and 20 nM respectively. |
![]() |
V52646 | Emodin-d4 (Frangula emodin-d4) | 132796-52-2 | Emodin-d4 is the deuterium labelled form of Emodin. |
![]() |
V52083 | FPFT-2216 | 2367619-87-0 | FPFT-2216 is a "molecular glue" compound that degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). |
![]() |
V55053 | IQA (CGP-029482) | 391670-48-7 | IQA (CGP-029482) is a potent and specific inhibitor of protein kinase CK2. |
![]() |
V51919 | JNJ-6204 | 2765264-50-2 | JNJ-6204 is a dual (bifunctional) inhibitor of CSNK1D and CSNK1E (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM) and has good brain penetration. |
![]() |
V24087 | LH846 | 639052-78-1 | LH846 is a selective CKIδ inhibitor (antagonist) with IC50 of 290 nM; its inhibitory activity against CKIα and CKIε is relatively weak, with IC50s of 2.5 μM and 1.3 μM respectively. |
![]() |
V5237 | Longdaysin | 1353867-91-0 | Longdaysin is a novel and potent inhibitor of Casein Kinase (CK1α, CK1δ, CDK7) and ERK2 with IC50s of 5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively. |
![]() |
V104402 | MGD-28 | 2991818-13-2 | MGD-28 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. |
![]() |
V76739 | MU1742 | MU1742 is a probe for the detection of CK1δ and CK1ε kinases. | |
![]() |
V55065 | ON 108600 | 1585246-23-6 | ON 108600 is an inhibitor (blocker/antagonist) of CK2 (Casein Kinase2)/TNIK/DYRK1. |
![]() |
V41060 | Orobol | 480-23-9 | Orobol is a major soy isoflavone with multiple bioactivities such as anti-skin aging and anti-obesity effects. |
![]() |
V36627 | SGC-CK2-1 | 2470424-39-4 | SGC-CK2-1 is a highly efficient, ATP-competitive CK2 chemical probe that is selective for two human CK2 isoforms, CK2α and CK2α', with IC50s of 36 and 16 nM, respectively. |
![]() |
V84319 | SJ3149 | 3026986-17-1 | |
![]() |
V35259 | SR-1277 | 1446715-47-4 | SR-1277 is a specific and ATP-competitive CK1δ/ε inhibitor (antagonist) with IC50s of 49 nM and 260 nM, respectively. |
![]() |
V78620 | SR-4133 | 2999645-23-5 | SR-4133 is a potent and specific inhibitor of CK1ε with IC50 of 58 nM. |