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Casein Kinase

Casein Kinase

The ubiquitous Ser/Thr kinases known as casein kinases (CKs) control a variety of cellular processes in eukaryotes, including the phosphorylation of proteins that are targets for degradation by the ubiquitin-proteasome system (UPS). Casein kinase-1 (CK-1) and casein kinase-2 (CK-2) have both been extensively characterized.
Mammals have at least seven different isoforms of CK1 kinases (,, 1-3,, and ), and these enzymes phosphorylate different substrates to participate in a variety of physiological processes including DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis.A highly pleiotropic serine-threonine kinase called casein kinase 2 (CK2) phosphorylated more than 300 proteins, many of which are involved in the regulation of cellular processes like signal transduction, transcriptional control, apoptosis, and the cell cycle.

Casein Kinase related products

Structure Cat No. Product Name CAS No. Product Description
CSNK2-IN-1 V88607 CSNK2-IN-1 CSNK2-IN-1 is a potent and selective CSNK2 inhibitor with IC50 of 1.7 nM and 0.66 nM for CSNK2A1 and CSNK2A2, respectively.
CSNK2A-IN-1 V84911 CSNK2A-IN-1 3029550-24-8
CSNK2A-IN-2 V84725 CSNK2A-IN-2
dCK1α-2 V104611 dCK1α-2 dCK1α-2 is an oral CK1α molecular glue degrader that can target p53 pathway-related targets.
DEG-77 V85404 DEG-77 3032265-06-5
Ellagic acid (hydrate) V69798 Ellagic acid (hydrate) 314041-08-2 Ellagic acid hydrate is a natural antioxidant and a potent, ATP-competitive CK2 inhibitor (antagonist) with IC50 and Kis of 40 nM and 20 nM respectively.
Emodin-d4 (Frangula emodin-d4) V52646 Emodin-d4 (Frangula emodin-d4) 132796-52-2 Emodin-d4 is the deuterium labelled form of Emodin.
FPFT-2216 V52083 FPFT-2216 2367619-87-0 FPFT-2216 is a "molecular glue" compound that degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α).
IQA (CGP-029482) V55053 IQA (CGP-029482) 391670-48-7 IQA (CGP-029482) is a potent and specific inhibitor of protein kinase CK2.
JNJ-6204 V51919 JNJ-6204 2765264-50-2 JNJ-6204 is a dual (bifunctional) inhibitor of CSNK1D and CSNK1E (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM) and has good brain penetration.
LH846 V24087 LH846 639052-78-1 LH846 is a selective CKIδ inhibitor (antagonist) with IC50 of 290 nM; its inhibitory activity against CKIα and CKIε is relatively weak, with IC50s of 2.5 μM and 1.3 μM respectively.
Longdaysin V5237 Longdaysin 1353867-91-0 Longdaysin is a novel and potent inhibitor of Casein Kinase (CK1α, CK1δ, CDK7) and ERK2 with IC50s of  5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively.
MGD-28 V104402 MGD-28 2991818-13-2 MGD-28 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner.
MU1742 V76739 MU1742 MU1742 is a probe for the detection of CK1δ and CK1ε kinases.
ON 108600 V55065 ON 108600 1585246-23-6 ON 108600 is an inhibitor (blocker/antagonist) of CK2 (Casein Kinase2)/TNIK/DYRK1.
Orobol V41060 Orobol 480-23-9 Orobol is a major soy isoflavone with multiple bioactivities such as anti-skin aging and anti-obesity effects.
SGC-CK2-1 V36627 SGC-CK2-1 2470424-39-4 SGC-CK2-1 is a highly efficient, ATP-competitive CK2 chemical probe that is selective for two human CK2 isoforms, CK2α and CK2α', with IC50s of 36 and 16 nM, respectively.
SJ3149 V84319 SJ3149 3026986-17-1
SR-1277 V35259 SR-1277 1446715-47-4 SR-1277 is a specific and ATP-competitive CK1δ/ε inhibitor (antagonist) with IC50s of 49 nM and 260 nM, respectively.
SR-4133 V78620 SR-4133 2999645-23-5 SR-4133 is a potent and specific inhibitor of CK1ε with IC50 of 58 nM.
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