The -phosphate group of ATP is transferred to protein substrates by the Ser/Thr phosphoryl transferase known as PKA. More than 100 membrane- and cytoplasmic-associated targets are phosphorylated by PKA. PKA mediates a wide range of cellular signaling activities, and its activity is strictly controlled in both time and space.
The hedgehog (Hh) signal transduction pathway is negatively regulated by PKA, an evolutionary conserved protein. The proteolytic processing step that results in the repressor forms of the Ci and Gli transcription factors, which turn off target genes in the absence of Hh, is known to require PKA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V88105 | 4-Cyano-3-methylisoquinoline | 161468-32-2 | 4-Cyano-3-methylisoquinoline is a protein kinase A (PKA) inhibitor with IC50 in the micromolar range. |
|
V88114 | 6-Bn-cAMP | 32115-08-5 | 6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) but does not activate Epac. |
|
V69112 | 6-Bnz-cAMP sodium salt | 1135306-29-4 | 6-Bnz-cAMP sodium salt is a cell-permeable (penetrable) cAMP analog. |
|
V88108 | 6-Phe-cAMP | 34051-30-4 | 6-Phe-cAMP is a site-selective, highly membrane-permeable protein kinase A (PKA) activator with a strong preference for site A of both isozymes. |
|
V86776 | 8-Br-cAMP-AM | 190522-24-8 | 8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that activates two major signal transduction pathways in the heart by mimicking the effects of cAMP: protein kinase A (PKA) and guanosine nucleotide exchange factor (Epac) directly activated by cAMP. |
|
V88120 | 8-Br-cGMP-AM | 272445-71-3 | 8-Br-cGMP-AM is a derivative of 8-Br-cGMP. |
|
V91723 | 8-Bromo-cAMP | 23583-48-4 | 8-Bromo-cAMP (8-Br-Camp) is a cyclic AMP analog and a cyclic AMP-dependent protein kinase (PKA) activator. |
|
V88112 | 8-Chloro-cAMP sodium | 124705-03-9 | 8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. |
|
V88097 | 8-CPT-6-Phe-cAMP | 72549-36-1 | 8-CPT-6-Phe-cAMP is an analog of the signaling molecule cAMP and a potent protein kinase A (PKA) activator. |
|
V88107 | 8-HA-cAMP | 59212-44-1 | 8-HA-cAMP is a membrane-permeable cAMP analog and activator of cAMP-dependent protein kinase and PKA I. |
|
V88113 | 8-MA-cAMP | 33823-18-6 | 8-MA-cAMP (8-Methylamino-cAMP) is a cyclic AMP analog that acts as a site-selective PKA agonist with similar affinity for the B site of type I and type II protein kinase A. |
|
V88106 | 8-OH-cAMP | 31356-95-3 | 8-OH-cAMP (8-Hydroxy-cAMP) is a polar, membrane-impermeable cyclic adenosine monophosphate analog that is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. |
|
V88109 | 8-pCPT-5'-AMP | 78710-84-6 | 8-pCPT-5'-AMP is a 5'-AMP analog and a lipophilic activator of PKA, PKG, and Epac (cAMP-activated exchange protein). |
|
V88116 | 8-pCPT-cGMP-AM | 272445-72-4 | 8-pCPT-cGMP-AM (8-(4-Chlorophenylthio)-cGMP-AM) is a highly membrane-permeable prodrug form of the PKG agonist 8-pCPT-cGMP. |
|
V88111 | 8-PIP-cAMP | 31357-06-9 | 8-PIP-cAMP is a selective cAMP-dependent protein kinase activator useful in cancer research. |
|
V1847 | 8-Bromo-cAMP sodium | 76939-46-3 | 8-Bromo-cAMP sodium is a potent and cell permeable cyclic AMP (cAMP) analog and a PKA activator. |
|
V88133 | AACA | 2515609-54-6 | AACA is an inhibitor of sclerostin, binding to sclerostin in the loop3 region with a Kd of 15.4 nM. |
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V78101 | Aplithianines A | 3027425-38-0 | Aplithianines A is a potent J-PKAcα inhibitor (antagonist) with IC50 of 1 μM and IC50 of 84 nM against wild-type PKA. |
|
V78154 | ATP Synthesis-IN-3 | 3032416-36-4 | ATP Synthesis-IN-3 (compound 31) is an ATP hydrolysis inhibitor and has a protective effect during myocardial ischemia. |
|
V69118 | BLU0588 | 2810747-78-3 | BLU0588 is an orally potent and specific PRKACA (protein kinase cAMP-activated catalytic subunit alpha) kinase inhibitor (antagonist) with IC50 of 1 nM and a dissociation constant (Kd) of 4 nM. |
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