YAP (Yes-associated protein) regulates cell growth, tissue homeostasis, and organ size as a transcription co-activator in the Hippo tumor suppressor pathway. The kinase Lats inhibits YAP by phosphorylating it, causing it to localize to the cytoplasm and be degraded by proteasomes. By attaching to transcription factors from the TEAD family, YAP stimulates the expression of genes.
YAP has a complicated role in human cancer that may vary depending on the cell type. For instance, by inducing apoptosis in response to DNA damage, YAP may act as a tumor suppressor in some cell types, such as hematological cancers.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V81480 | Super-TDU (1-31) | Super-TDU (1-31) is the peptide fragment of Super-TDU. | |
|
V76465 | Super-TDU (1-31) (TFA) | Super-TDU (1-31) TFA is the peptide fragment of Super-TDU. | |
|
V81481 | Super-TDU TFA | Super-TDU TFA is a specific YAP antagonist that targets the YAP-TEAD interaction. | |
|
V69179 | SWTX-143 | 2766575-48-6 | SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. |
|
V103158 | TEAD-IN-1 | 2412761-57-8 | TEAD-IN-1 (Compound 2) is a potent TEAD autopalmitoylation inhibitor with IC50 of 603 nM. |
|
V88145 | TEAD-IN-10 | 3032196-65-6 | TEAD-IN-10 (compound 15) has good inhibitory effects on TEAD1 (IC50=14 nM), TEAD2 (IC50=179 nM), and TEAD3 (IC50=4 nM). |
|
V88149 | TEAD-IN-11 | 3032196-88-3 | TEAD-IN-11 (compound 38) has good inhibitory effects on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), and TEAD3 (IC50=5.6 nM). |
|
V88150 | TEAD-IN-12 | 3034813-66-3 | TEAD-IN-12 (58B) is an orally active TEAD inhibitor with IC50 of <100 nM and half-life of 3.6 h in mice. |
|
V88148 | TEAD-IN-13 | 3034813-74-3 | TEAD-IN-13 (64) is an orally active TEAD inhibitor with an IC50 value of <100 nM and a half-life of 3.2 h in mice. |
|
V88146 | TEAD-IN-14 | TEAD-IN-14 (75a) is an orally active TEAD inhibitor with IC50 of <100 nM and half-life of 2.3 h in mice. | |
|
V88152 | TEAD-IN-16 | TEAD-IN-16 (compound BC-011) is a potent inhibitor of TEAD with IC50 of 72.43 μM. | |
|
V69183 | TEAD-IN-6 | 2821763-12-4 | TEAD-IN-6 (Example 11-1) is a TEAD modulator that blocks the interaction between YAP1/TAZ and TEAD. |
|
V84549 | TEAD-IN-8 | 1008768-41-9 | |
|
V88144 | TEAD-IN-9 | TEAD-IN-9 (compound 17) is a TEAD1 inhibitor with IC50 of 0.29 μM. | |
|
V38733 | TED-347 | 2378626-29-8 | TED-347 (TED347) is a novel,covalent/irreversible,and allostericYAP-TEAD protein-protein interaction inhibitor with anticancer activity. |
|
V69174 | TRULI (Lats-IN-1) | 1424635-83-5 | TRULI (Lats-IN-1) is a potent, ATP-competitive inhibitor of Lats1 and Lats2 kinases. |
|
V69178 | TT-10 (TAZ-K) | 2230640-94-3 | TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcription enhancer domain (TEAD) activity. |
|
V76351 | VT02956 | 2999763-09-4 | VT02956 is a LATS inhibitor (IC50= 0.76 nM for LATS1 and 0.52 nM for LATS2). |
|
V85490 | VT02956 hydrochloride | ||
|
V39633 | YAP-TEAD-IN-1 TFA | 1659305-79-9 | YAP-TEAD-IN-1 TFA is a potent competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). |
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