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YAP

YAP

YAP (Yes-associated protein) regulates cell growth, tissue homeostasis, and organ size as a transcription co-activator in the Hippo tumor suppressor pathway. The kinase Lats inhibits YAP by phosphorylating it, causing it to localize to the cytoplasm and be degraded by proteasomes. By attaching to transcription factors from the TEAD family, YAP stimulates the expression of genes.

YAP has a complicated role in human cancer that may vary depending on the cell type. For instance, by inducing apoptosis in response to DNA damage, YAP may act as a tumor suppressor in some cell types, such as hematological cancers.

YAP related products

Structure Cat No. Product Name CAS No. Product Description
(R)-VT104 V69181 (R)-VT104 2417718-26-2 (R)-VT104 is the R-enantiomer of VT104.
AF-2112 V79706 AF-2112 AF-2112 is a Flufenamic acid-derived TEAD inhibitor that strongly reduces the expression of CTGF, Cyr61, Axl, and NF2.
DC-TEADin02 V69180 DC-TEADin02 2380228-45-3 DC-TEADin02 is a potent inhibitor of TEAD autopalmitoylation.
GA-017 V12043 GA-017 2351906-74-4 GA-017 is a potent and specific LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor (antagonist) with IC50s of 4.10 and 3.92 nM, respectively.
GNE-7883 V69176 GNE-7883 2648450-42-2 GNE-7883 is a generic TEAD inhibitor (antagonist) with anti-cell proliferation/growth activity.
HC-258 V85993 HC-258
IK-930 V69175 IK-930 2563892-44-2 IK-930 (compound I-32) is a potent orally bioactive TEAD inhibitor (antagonist) with EC50 <0.1 µM.
LM-41 V79966 LM-41 LM-41 is a Flufenamic acid-derived TEAD inhibitor that strongly reduces the expression of CTGF, Cyr61, Axl, and NF2.
mCMY020 V79664 mCMY020 mCMY020 is a TEAD covalent inhibitor.
MY-1076 V78452 MY-1076 MY-1076 is an inhibitor (blocker/antagonist) of YAP.
MYF-01-37 V2270 MYF-01-37 2416417-65-5 MYF-01-37 is a novel, potent and covalent TEAD inhibitor with anticancer activity.
Super-TDU V3198 Super-TDU 1599441-71-0 Super-TDU is a rationally designed peptide-based inhibitor targeting the YAP-TEADs interaction by mimicking the VGLL with anticancer activity.
Super-TDU (1-31) V81480 Super-TDU (1-31) Super-TDU (1-31) is the peptide fragment of Super-TDU.
Super-TDU (1-31) (TFA) V76465 Super-TDU (1-31) (TFA) Super-TDU (1-31) TFA is the peptide fragment of Super-TDU.
Super-TDU TFA V81481 Super-TDU TFA Super-TDU TFA is a specific YAP antagonist that targets the YAP-TEAD interaction.
SWTX-143 V69179 SWTX-143 2766575-48-6 SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms.
TEAD-IN-6 V69183 TEAD-IN-6 2821763-12-4 TEAD-IN-6 (Example 11-1) is a TEAD modulator that blocks the interaction between YAP1/TAZ and TEAD.
TEAD-IN-8 V84549 TEAD-IN-8 1008768-41-9
TED-347 V38733 TED-347 2378626-29-8 TED-347 (TED347) is a novel,covalent/irreversible,and allostericYAP-TEAD protein-protein interaction inhibitor with anticancer activity.
TRULI (Lats-IN-1) V69174 TRULI (Lats-IN-1) 1424635-83-5 TRULI (Lats-IN-1) is a potent, ATP-competitive inhibitor of Lats1 and Lats2 kinases.
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