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YAP

YAP

YAP (Yes-associated protein) regulates cell growth, tissue homeostasis, and organ size as a transcription co-activator in the Hippo tumor suppressor pathway. The kinase Lats inhibits YAP by phosphorylating it, causing it to localize to the cytoplasm and be degraded by proteasomes. By attaching to transcription factors from the TEAD family, YAP stimulates the expression of genes.

YAP has a complicated role in human cancer that may vary depending on the cell type. For instance, by inducing apoptosis in response to DNA damage, YAP may act as a tumor suppressor in some cell types, such as hematological cancers.

YAP related products

Structure Cat No. Product Name CAS No. Product Description
(7S)-BAY-593 V91788 (7S)-BAY-593 2413068-25-2 (7S)-BAY-593 is the S-isomer of BAY-593.
(R)-VT104 V69181 (R)-VT104 2417718-26-2 (R)-VT104 is the R-enantiomer of VT104.
AF-2112 V79706 AF-2112 AF-2112 is a Flufenamic acid-derived TEAD inhibitor that strongly reduces the expression of CTGF, Cyr61, Axl, and NF2.
BAY-593 V88143 BAY-593 2413020-56-9 BAY-593 is an orally active GGTase-I inhibitor.
DC-TEADin02 V69180 DC-TEADin02 2380228-45-3 DC-TEADin02 is a potent inhibitor of TEAD autopalmitoylation.
GA-017 V12043 GA-017 2351906-74-4 GA-017 is a potent and specific LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor (antagonist) with IC50s of 4.10 and 3.92 nM, respectively.
GNE-7883 V69176 GNE-7883 2648450-42-2 GNE-7883 is a generic TEAD inhibitor (antagonist) with anti-cell proliferation/growth activity.
HC-258 V85993 HC-258
IAG933 V69177 IAG933 2714434-21-4 IAG933 (YAP-TEAD-IN-3; compound 155) is a YAP/TAZ-TEAD inhibitor.
IK-930 V69175 IK-930 2563892-44-2 IK-930 (compound I-32) is a potent orally bioactive TEAD inhibitor (antagonist) with EC50 <0.1 µM.
LM-41 V79966 LM-41 2996821-30-6 LM-41 is a Flufenamic acid-derived TEAD inhibitor that strongly reduces the expression of CTGF, Cyr61, Axl, and NF2.
mCMY020 V79664 mCMY020 mCMY020 is a TEAD covalent inhibitor.
MSC-1254 V94432 MSC-1254 MSC-1254 is a reversible, selective and covalent TEAD1 inhibitor.
MSC-5046 V94443 MSC-5046 MSC-5046 is a selective TEAD1 inhibitor.
MY-1076 V78452 MY-1076 3008262-76-5 MY-1076 is an inhibitor (blocker/antagonist) of YAP.
MYF-01-37 V2270 MYF-01-37 2416417-65-5 MYF-01-37 is a novel, potent and covalent TEAD inhibitor with anticancer activity.
NIBR-LTSi V88142 NIBR-LTSi NIBR-LTSi is a selective LATS kinase inhibitor that activates YAP signaling.
Super-TDU V3198 Super-TDU 1599441-71-0 Super-TDU is a rationally designed peptide-based inhibitor targeting the YAP-TEADs interaction by mimicking the VGLL with anticancer activity.
Super-TDU (1-31) V81480 Super-TDU (1-31) Super-TDU (1-31) is the peptide fragment of Super-TDU.
Super-TDU (1-31) (TFA) V76465 Super-TDU (1-31) (TFA) Super-TDU (1-31) TFA is the peptide fragment of Super-TDU.
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