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HBV

HBV

Hepatitis B virus, also known as HBV or Orthohepadnavirus, is a type of virus that belongs to the Hepadnaviridae family of viruses. Hepatitis B is brought on by the virus HBV. The ground squirrel hepatitis virus, the woodchuck hepatitis virus, and the woolly monkey hepatitis B virus are the other three species that make up the Orthohepadnavirus, of which the hepatitis B virus is the type species. The Hepadnaviridae family includes the genus as a member. Based on antigenic epitopes found on its envelope proteins, HBV is classified into four major serotypes (adr, adw, ayr, ayw), and eight genotypes (A-H) based on the genome's overall nucleotide sequence variation.The genotypes are used to track the evolution and spread of the virus because they have a distinct geographic distribution. The severity of the disease, the progression and propensity for complications, the response to treatment, and perhaps vaccination, are all impacted by genotype differences.

HBV related products

Structure Cat No. Product Name CAS No. Product Description
HBV-IN-31 V52007 HBV-IN-31 2413192-95-5 HBV (hepatitis B virus)-IN-31 is a potent inhibitor of covalently closed circular DNA (cccDNA).
HBV-IN-32 V52006 HBV-IN-32 2413193-04-9 HBV (hepatitis B virus)-IN-31 is a potent inhibitor of covalently closed circular DNA (cccDNA).
HBV-IN-33 V79034 HBV-IN-33 HBV (hepatitis B virus)-IN-33 (C-49) is an inhibitor (blocker/antagonist) of HBV (hepatitis B virus) and significantly inhibits HBV (hepatitis B virus) replication in HepAD38, HepG2-HBV (hepatitis B virus)1.3 and HepG2-NTCP cells.
HBV-IN-34 V54179 HBV-IN-34 2716906-45-3 HBV (hepatitis B virus)-IN-34 (compound 17i) is a potent inhibitor of HBsAg production.
HBV-IN-35 V79441 HBV-IN-35 HBV (hepatitis B virus)-IN-35 (Compound 88) is an HBV (hepatitis B virus) inhibitor.
HBV-IN-36 V79710 HBV-IN-36 HBV (hepatitis B virus)-IN-36 (compound 42) is a potent HBV (hepatitis B virus) inhibitor (IC50=2 μM) with antiviral effect.
HBV-IN-37 V54204 HBV-IN-37 380483-01-2 HBV (hepatitis B virus)-IN-37 is an HBV (hepatitis B virus) inhibitor (antagonist) with EC50 of 10 μM.
HBV-IN-38 V54210 HBV-IN-38 1834483-86-1 HBV (hepatitis B virus)-IN-38 (Example 193) is an HBV (hepatitis B virus) DNA inhibitor (EC50≤100nM).
HBV-IN-39-d3 V54200 HBV-IN-39-d3 2173356-23-3 HBV (hepatitis B virus)-IN-39-d3 (Example 14) is a deuterated form of HBV (hepatitis B virus)-IN-39 (Example 13).
HBV-IN-40 V78340 HBV-IN-40 HBV (hepatitis B virus)-IN-40 (Compound 11826096) is an HBV (hepatitis B virus) inhibitor (IC50= 0.7 μM).
HBV-IN-41 V54183 HBV-IN-41 1967002-25-0 HBV (hepatitis B virus)-IN-41 (compound 45) is a potent orally bioactive HBV (hepatitis B virus) inhibitor (antagonist) with EC50 of 0.027μM.
HBV-IN-43 V85418 HBV-IN-43 2305897-05-4
HBV-IN-6 V54197 HBV-IN-6 2724224-47-7 HBV (hepatitis B virus)-IN-6 is a potent HBV (hepatitis B virus) inhibitor (antagonist) with EC50 of 44 nM.
HBV-IN-7 V54185 HBV-IN-7 2724224-49-9 HBV (hepatitis B virus)-IN-6 is a potent HBV (hepatitis B virus) inhibitor (antagonist) with EC50 of 5 nM.
HBV-IN-8 V54175 HBV-IN-8 2724224-57-9 HBV (hepatitis B virus)-IN-6 is a potent HBV (hepatitis B virus) inhibitor (antagonist) with EC50 of 287.9 nM.
HBV-IN-9 V54176 HBV-IN-9 2170998-69-1 HBV (hepatitis B virus)-IN-9 (example 20) is a potent HBsAg (HBV (hepatitis B virus) surface antigen) inhibitor (IC50=10 nM) and HBV (hepatitis B virus) DNA replication inhibitor (IC50=0.15 nM).
Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) V54188 Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) 114495-85-1 Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog that specifically binds to Hep G2 cells.
Inarigivir ammonium (ORI-9020 ammonium; SB-9000 ammonium) V51949 Inarigivir ammonium (ORI-9020 ammonium; SB-9000 ammonium) 2172788-92-8 Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral compound that significantly reduces HBV (hepatitis B virus) DNA in transgenic mice expressing hepatitis B virus.
Isoscopoletin V29343 Isoscopoletin 776-86-3 Isoscopoletin is a novel and potent bioactive compound.
JNJ-632 V4501 JNJ-632 1572510-42-9 JNJ-632 is a novel and potent hepatitis B virus (HBV) capsid assembly modulator (CAM).
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