The acquired immunodeficiency syndrome (AIDS), a condition in which the immune system gradually fails and life-threatening opportunistic infections and cancers proliferate, is brought on by the lentivirus (a subgroup of retrovirus) known as HIV. HIV infection happens when blood, semen, vaginal fluid, pre-ejaculate, or breast milk are shared. HIV can be found in these bodily fluids as both free virus particles and as a virus inside infected immune cells.Important immune system components like helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells are all infected by HIV. Apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells are some of the mechanisms by which HIV infection results in low levels of CD4+ T cells. Cell-mediated immunity is lost and the body becomes progressively more vulnerable to opportunistic infections when CD4+ T cell counts fall below a critical threshold.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76313 | GSK2838232 | 1443460-91-0 | GSK2838232 inhibits HIV reverse transcriptase activity. |
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V101461 | GSK878 | 2417048-11-2 | GSK878 is a highly potent and long-acting HIV-1 inhibitor with an EC50 value of 39 pM. |
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V52012 | HBV Seq2 aa:179-186 | 337464-42-3 | HBV (hepatitis B virus) Seq2 aa:179-186 serves as an efficient motif for CTL responses in the H-2b system after restimulation of primed T cells in vitro. |
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V76178 | HEP-1 Acetate (Human ezrin peptide (324-337)) | 174641-44-2 | HEP-1 (Human ezrin peptide (324-337)) is an orally administered peptide with anti-HIV activity. |
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V86016 | HIV capsid modulator 1 | 3031547-95-9 | |
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V101784 | HIV capsid modulator 2 | HIV capsid regulator 2 (compound 7t) is a regulator of HIV capsid protein (CA). | |
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V101745 | HIV gp120 (318-327) | 147841-68-7 | HIV gp120 (318-327) is a short sequence of HIV-1 strain IIIB envelope peptide (rgpgrafvti) that corresponds to the conserved C-terminal region of the glycoprotein. |
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V51988 | HIV-1 capsid inhibitor 1 | 2396382-78-6 | HIV-1 capsid inhibitor 1 is a potent HIV-1 Capsid inhibitor (antagonist) with EC50 of 3.13 µM. |
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V54246 | HIV-1 inhibitor-10 | 1449660-81-4 | HIV-1 inhibitor-10 is a nanomolar inhibitor of HIV-1 maturation. |
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V76169 | HIV-1 inhibitor-13 | 2761172-60-3 | HIV-1 inhibitor-13 (compound 16c) is an orally bioactive HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 0.14 μM (HIV-1 RT). |
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V76179 | HIV-1 inhibitor-14 | 2761172-65-8 | HIV-1 inhibitor-14 (compound 14b) is a highly efficient and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor (antagonist) with IC50 of 0.14 μM for HIV-1 RT. |
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V76177 | HIV-1 inhibitor-17 | 2764787-76-8 | HIV-1 inhibitor-18 (compound V-25i) is a potent HIV-1 capsid inhibitor (antagonist) with EC50 of 2.57 μM against HIV-1 NL4-3 strain. |
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V76173 | HIV-1 inhibitor-18 | 2764787-56-4 | HIV-1 inhibitor-18 (compound II-13c) is a potent HIV-1 capsid inhibitor (antagonist) with EC50 of 5.14 μM against HIV-1 NL4-3 strain. |
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V53323 | HIV-1 inhibitor-48 | 374067-85-3 | HIV-1 inhibitor-48 (compound 13o) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV (Human Immunodeficiency Virus)-1 activity. |
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V51987 | HIV-1 inhibitor-50 | 2834087-69-1 | HIV-1 inhibitor-50 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1 reverse transcriptase (RT) (IC50=50 nM). |
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V54263 | HIV-1 inhibitor-51 | 2834087-82-8 | HIV-1 inhibitor-51 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that displays excellent antiviral effect against WT HIV-1 (IIIB) and a panel of mutant strains. |
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V54298 | HIV-1 inhibitor-52 | 1818868-23-3 | HIV-1 inhibitor-52 is an effective broad-spectrum HIV-1 activity inhibitor, effective against WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/ The EC50 of prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M is 1.6 nM-6.4 nM. |
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V51985 | HIV-1 inhibitor-54 | 2771211-71-1 | HIV-1 inhibitor-54 is a potent HIV-1 inhibitor. |
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V51984 | HIV-1 inhibitor-55 | 2771211-73-3 | HIV-1 inhibitor-55 (compound 4d) inhibits WT HIV-1 with EC50 of 8.6 nM. |
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V54286 | HIV-1 inhibitor-56 | 2952530-45-7 | HIV-1 inhibitor-56 (compound 12126065) is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor. |
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