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HIV

HIV

The acquired immunodeficiency syndrome (AIDS), a condition in which the immune system gradually fails and life-threatening opportunistic infections and cancers proliferate, is brought on by the lentivirus (a subgroup of retrovirus) known as HIV. HIV infection happens when blood, semen, vaginal fluid, pre-ejaculate, or breast milk are shared. HIV can be found in these bodily fluids as both free virus particles and as a virus inside infected immune cells.Important immune system components like helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells are all infected by HIV. Apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells are some of the mechanisms by which HIV infection results in low levels of CD4+ T cells. Cell-mediated immunity is lost and the body becomes progressively more vulnerable to opportunistic infections when CD4+ T cell counts fall below a critical threshold.

HIV related products

Structure Cat No. Product Name CAS No. Product Description
(-)-Rabdosiin V54276 (-)-Rabdosiin 119152-54-4 (-)-Rabdosiin is a novel phenolic marker discovered from Symphytum officinale L.
(2RS)-FPMPA V54273 (2RS)-FPMPA 135295-27-1 (2RS)-FPMPA may be utilized to prepare antiretroviral reagents against HIV-1 and HIV-2.
(2S,5S)-Censavudine ((2S,5S)-OBP-601; (2S,5S)-BMS-986001) V77391 (2S,5S)-Censavudine ((2S,5S)-OBP-601; (2S,5S)-BMS-986001) (2S,5S)-Censavudine ((2S,5S)-OBP-601) is the (2S,5S)-enantiomer of Censavudine.
(Cys47)-HIV-1 tat Protein (47-57) V54295 (Cys47)-HIV-1 tat Protein (47-57) 627079-23-6 (Cys47)-HIV-1 tat Protein (47-57) possesses membrane translocation capabilities and may be utilized to derivatize the surface of magnetically active molecules and facilitate their uptake into target cells.
(S)-Tenofovir V40146 (S)-Tenofovir 147127-19-3 (S)-Tenofovir [known also as (S)-GS 1278], the S-enantiomer of Tenofovir and a less active isomer,is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV).
(Z)-9-Propenyladenine ((Z)-替诺福韦酯杂质; (Z)-Mutagenic Impurity of Tenofovir Disoproxil) V53005 (Z)-9-Propenyladenine ((Z)-Mutagenic Impurity of Tenofovir Disoproxil) 1464851-21-5 (Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate.
2F5 epitope V54297 2F5 epitope 470704-11-1 The 2F5 epitope is a fragment of the peptide gp41 (659-671) that contains the complete epitope of one of three known antibodies capable of neutralizing a broad spectrum of primary HIV-1 isolates, and is the only such contiguous epitope.
3-Phenanthrenebutyric acid V2383 3-Phenanthrenebutyric acid 13728-56-8 HIV-1 Nef-IN-1 is an inhibitor (blocker/antagonist) of HIV-1 Nef protein that effectively competes for the Nef-SH3Hck interaction with Kd of 6.7 μM.
4-Deoxy-4α-phorbol V76170 4-Deoxy-4α-phorbol 37415-57-9 4-Deoxy-4α-phorbol is a tetracyclic diterpenoid found in E.
7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) V54306 7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) 111869-49-9 7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2',3'-dideoxynucleoside 5'-triphosphate that can inhibit HIV-1 reverse transcriptase with Ki of 25 nM.
9-Propenyladenine V32833 9-Propenyladenine 1446486-33-4 9-Propenyladenine is an impurity found in tenofovir disoproxil fumarate with mutagenicity.
Alvircept sudotox (U 85855) V54254 Alvircept sudotox (U 85855) 137487-62-8 Alvircept sudotox is a recombinant CD4 derived from Pneumonas aeruginosa exotoxin A.
Amphotericin B methyl ester V40231 Amphotericin B methyl ester 36148-89-7 Amphotericin B methyl ester, the methyl ester derivativeof Amphotericin B (A-634250), is a cholesterol-binding compound with potent antifungal activity.
Amphotericin B methyl ester hydrochloride (盐酸两性霉素B甲酯) V52422 Amphotericin B methyl ester hydrochloride 35375-29-2 Amphotericin B methyl ester HCl is the methyl ester analogue of the polyene antibiotic Amphotericin B (A634250).
Anti-Mouse CD4 Antibody (YTS 191) V77253 Anti-Mouse CD4 Antibody (YTS 191) Anti-Mouse CD4 Antibody (YTS 191) is an anti-mouse CD4 IgG2b antibody inhibitor, and the host is Rat.
Antiviral agent 45 V85460 Antiviral agent 45
Antiviral agent 9 V78085 Antiviral agent 9 The EC50 of antiviral compound 9 against HIV-1 reaches picomolar concentration (0.006 nM), and the selectivity index (SI) is nearly 300 times higher than that of tenofovir alafenamide fumarate (TAF).
Apelin-36(rat, mouse) V54245 Apelin-36(rat, mouse) 230299-95-3 Apelin-36 (rat, mouse) is an endogenous orphan G protein-coupled receptor APJ agonist.
APOBEC3G-IN-1 V53388 APOBEC3G-IN-1 14261-92-8 APOBEC3G-IN-1 (MN136.0185) is a potent HIV inhibitor targeting APOBEC3G.
Apricitabine [(-)-BCH10652; (-)-dOTC; AVX754; BCH10618; SPD754] V8732 Apricitabine [(-)-BCH10652; (-)-dOTC; AVX754; BCH10618; SPD754] 160707-69-7 Apricitabine [(-)-BCH-10652; (-)-dOTC; AVX-754; BCH-10618; SPD-754] isa highly potent, selective and orally bioactiveHIV-1 reverse transcriptase (RT)inhibitor withKiof 0.08 μM, belonging to thenucleoside reverse transcriptase inhibitor (NRTI) class of anti-HIV agents.
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