The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V83611 | SARS-CoV-2-IN-81 | ||
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V54423 | SARS-CoV-2-IN-9 | 1453052-57-7 | SARS-CoV-2-IN-9 is an inhibitor that binds to the SARS-CoV-2 major protease subunits S1 and S2. |
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V78299 | SARS-CoV-2/MERS Mpro-IN-1 | SARS-CoV-2/MERS Mpro-IN-1 (compound 9c) is a potent major protease inhibitor of SARS-CoV-2 and MERS with IC50s of 0.10 and 0.06 µM respectively. | |
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V81365 | SARS-CoV-2/MERS Mpro-IN-2 | SARS-CoV-2/MERS Mpro-IN-2 (compound 9d) is a potent major protease inhibitor of SARS-CoV-2 and MERS with IC50s of 0.21 and 0.07 µM respectively. | |
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V54434 | SBP1 peptide | 2416761-69-6 | SBP1 peptide is a chemically synthesized 23-mer peptide fragment on the PD α1 helix of ACE2. |
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V84176 | SHEN26 (ATV014) | 2691076-98-7 | |
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V81393 | Simaravibart (MAD-0004J08) | Simaravibart (MAD-0004J08) is an IgG1κ antibody targeting the SARS-CoV2 spike (S) glycoprotein receptor binding domain. | |
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V81394 | Simeprevir-13C,d3 (TMC435-13C,d3; TMC435350-13C,d3) | Simeprevir-13C,d3 is a 13C- and deuterium labelled Simeprevir. | |
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V54383 | Simpinicline (OC-02) | 753015-44-0 | Simpinicline (OC-02) is a selective nicotinic acetylcholine receptor (nAChR) agonist that shows potent antiviral effect against SARS-CoV-2 variants in cell culture with IC50 of 0.04 µM. |
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V36574 | SIMR3030 | 2708270-99-7 | SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor (antagonist) with IC50 of 0.0399 µg/mL. |
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V2638 | Sivelestat | 127373-66-4 | Sivelestat (also known as ONO5046; LY544349; EI546) is a novel, potent and competitive inhibitor of human neutrophil elastase (HNE) with IC50value of44 nM andKi of 200 nM; it also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
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V35268 | Sotrovimab (VIR 7831) | 2423014-07-5 | Sotrovimab (VIR 7831) is a human IgG1κ pan-coronavirus (sarbecvirus) monoclonal antibody (mAb) that neutralizes SARS-CoV-2, SARS-CoV-1 and multiple other coronaviruses. |
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V76091 | SP inhibitor 1 | 2766185-81-1 | SP inhibitor 1 (compound 34) is a selective SARS-CoV-2 spike protein (SP) inhibitor (antagonist) with IC50s of 3.26 μM, >25 μM, and >25 μM for SP, Mpro, and PLpro proteins respectively. |
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V79058 | SPR38 | SPR38 is a potent inhibitor of SARS-CoV-2 main protease with Ki of 0.260 μM. | |
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V79074 | SPR39 | SPR39 is a potent SARS-CoV-2 main protease inhibitor, with Kis of 0.252, 3.38, and 7.88 µM for SARS-CoV-2 Mpro, hCatL, and hCatB respectively. | |
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V78587 | SPR41 | SPR41 is a potent SARS-CoV-2 major protease inhibitor (antagonist) with Kis of 0.184, 0.252, and 14.4 µM for SARS-CoV-2 Mpro, hCatL, and hCatB respectively. | |
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V86137 | SS148 | 1985669-27-9 | |
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V54430 | SSAA09E1 | 433212-75-0 | SSAA09E1 is a cathepsin L (cathepsin L) blocker (IC50= 5.33 μM). |
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V52986 | SSAA09E2 | 883944-52-3 | SSAA09E2 is a novel SARS-CoV replication inhibitor that works by blocking the early interaction of SARS-S with the SARS-CoV receptor angiotensin-converting enzyme-2 (ACE2). |
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V35257 | SSAA09E3 | 52869-18-8 | SSAA09E3 is a SARS-CoV entry inhibitor that can suppress the entry of SARS/HIV pseudotyped viruses into 293T cells with EC50 of 9.7 μM. |
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