The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V35251 | STING agonist-30 | 2951078-67-2 | STING agonist-30 is a potent STING agonist. |
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V54395 | Tanshinlactone | 105351-70-0 | Tanshinlactone is a secondary rosin compound that can be extracted from Salvia miltiorrhiza. |
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V34737 | Teicoplanin sodium (Antibiotic MDL-507 sodium; MDL-507 sodium) | 184539-13-7 | Teicoplanin sodium (Antibiotic MDL-507 sodium) is an effective lipoglycopeptide antibiotic. |
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V81552 | Telaprevir-d4 (VX-950-d4) | Telaprevir-d4 is the deuterium labelled form of Telaprevir. | |
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V52568 | Tipranavir-d4 (tipranavir d4) | 1217819-15-2 | Tipranavir-d4 is the deuterium labelled form of Tipranavir. |
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V54340 | tirfipiravir | 2759996-93-3 | Tirfipiravir is a nucleoside compound and antiviral compound that works against the novel coronavirus or influenza virus. |
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V54377 | Tixagevimab (AZD8895) | 2420564-02-7 | Tixagevimab (AZD8895) is a human monoclonal antibody (mAb) that targets the SARS-CoV-2 receptor-binding domain (RBD). |
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V54422 | TKB245 | 2892688-16-1 | TKB245 is a potent SARS-CoV-2 Mpro inhibitor that effectively blocks SARS-CoV-2 replication in VeroE6 cells. |
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V81669 | Umifenovir-d6 hydrochloride (Arbidol d6 hydrochloride (hydrochloride)) | Umifenovir-d6 ( HCl) is the deuterium labelled form of Umifenovir HCl. | |
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V35138 | Vilobelimab (CaCP-29, IFX-1) | 2250440-41-4 | Vilobelimab (CaCP-29, IFX-1) is a monoclonal antibody (mAb) against C5a, a proinflammatory complement cleavage product that plays a central role in mediating organ dysfunction. |
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V35076 | Viral polymerase-IN-1 hydrochloride | 2367587-02-6 | Viral polymerase-IN-1 HCl is a Gemcitabine analogue that effectively inhibits influenza A and B virus (influenza) infection with an IC90 value of 11.4-15.9 μM. |
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V4354 | VV116 | 2647442-33-7 | VV-116 (also known as VV116, JT-001) is a novel, potent and orally administered anti-SARS-CoV-2 nucleoside drug candidate (IC50 = 0.67±0.24 μM) acting asa viral RNA-dependent RNA polymerase (RdRp) inhibitor and isunder investigation for COVID-19 treatment in China. |
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V54415 | WU-04 | 2921711-74-0 | WU-04 is a non-covalent inhibitor of SARS-CoV-2, targeting the 3CLpro protein. |
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V76073 | X77 | 2455518-33-7 | X77 is a potent non-covalent inhibitor of SARS-CoV-2 protease (SARS-CoV-2 Mpro). |
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V38794 | XP-59 | 890402-73-0 | XP-59 is a potent SARS-CoV Mpro inhibitor (antagonist) with Ki of 0.1 nM. |
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V54403 | XR8-69 | 2817811-10-0 | XR8-69 is a SARS-CoV-2 PLpro inhibitor that displays low micromolar antiviral potency in SARS-CoV-2-infected human cells. |
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V76075 | XR8-89 | 2817811-16-6 | XR8-89 is a potent papain-like (PLpro) inhibitor (antagonist) with IC50 of 0.1 μM. |
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V54398 | Z-Arg-Leu-Arg-Gly-Gly-AMC | 167698-69-3 | Z-Arg-Leu-Arg-Gly-Gly-AMC is a bioactive peptide substrate of SARS-CoV PLpro. |
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V73065 | Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) | 371167-61-2 | Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. |
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V35097 | Z-LVG-CHN2 | 119670-30-3 | Z-LVG-CHN2 is an intracellular irreversible inhibitor of cysteine protease. |
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