SARS-CoV

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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SARS-CoV

The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.

The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.

SARS-CoV related products

Cat No.	Product Name	CAS No.	Product Description
V83456	SARS-CoV-2-IN-80	57341-12-5
V83611	SARS-CoV-2-IN-81
V103500	SARS-CoV-2-IN-82	924058-34-4	SARS-CoV-2-IN-82 (Compound A) is an inhibitor of programmed -1 ribosomal frameshift (-1 PRF) of SARS-CoV-2.
V103872	SARS-CoV-2-IN-84	214221-82-6	SARS-CoV-2-IN-84 (Compound 20) is a SARS-CoV-2 inhibitor targeting the 3CL protease (3CL Pro) of SARS-CoV-2 (IC50: 369.5 nM).
V88327	SARS-CoV-2-IN-86	368866-07-3	SARS-CoV-2-IN-86 (Compound 2734589) is a dual inhibitor of SARS-CoV-2 methyltransferases nsp14 and nsp16.
V101508	SARS-CoV-2-IN-89	1016762-41-6	SARS-CoV-2-IN-89 (Compound 2) is a SARS-CoV-2 inhibitor.
V54423	SARS-CoV-2-IN-9	1453052-57-7	SARS-CoV-2-IN-9 is an inhibitor that binds to the SARS-CoV-2 major protease subunits S1 and S2.
V101586	SARS-CoV-2-IN-90		SARS-CoV-2-IN-90 (Compound 3i) is a SARS-CoV-2 inhibitor.
V88329	SARS-CoV-2-IN-91		SARS-CoV-2-IN-91 (Compound 194) is an inhibitor of SARS-CoV 2 with EC50 of 28.92 μM.
V99866	SARS-CoV-2-IN-92	2123489-12-1	SARS-CoV-2-IN-92 (Compound 11) inhibits SARS-CoV-2 variants (EC50 = 0.48 μM), as well as SARS-CoV and MERS-CoV.
V99884	SARS-CoV-2-IN-93		SARS-CoV-2-IN-93 (compound 24) is an inhibitor of SARS-CoV-2 and HCoV-OC43.
V99850	SARS-CoV-2-IN-94		SARS-CoV-2-IN-94 (compound 6) exhibited antiviral activity against COVID-19 virus by targeting 6VSB protein.
V99854	SARS-CoV-2-IN-95	2817810-96-9	SARS-CoV-2-IN-95 (Compound 10) is an inhibitor of SARS-CoV-2 PLpro with IC50 of 0.39 μM.
V96826	SARS-CoV-2-IN-96		SARS-CoV-2-IN-96 (Compound 12b) is an inhibitor of HCoV-OC43 (EC50 = 97 nM) and SARS-CoV-2 (EC50 = 45 nM) with low cytotoxicity in Huh7 cells (CC50 10 μM).
V94833	SARS-CoV-2-IN-97	364338-71-6	SARS-CoV-2-IN-97 (Compound CO-01) is an inhibitor of SARS-CoV-2 Nsp15 endoribonuclease with IC50 of 53.5 μM.
V96643	SARS-CoV-2-IN-98		SARS-CoV-2-IN-98 (Compound 38) is a SARS-CoV-2 inhibitor with Kd of 0.73 μM, which can be used in COVID-19 research.
V94876	SARS-CoV-2-IN-99	2394839-81-5	SARS-CoV-2-IN-99 (Compound 58) is a major protease inhibitor of SARS-CoV-2.
V78299	SARS-CoV-2/MERS Mpro-IN-1		SARS-CoV-2/MERS Mpro-IN-1 (compound 9c) is a potent major protease inhibitor of SARS-CoV-2 and MERS with IC50s of 0.10 and 0.06 µM respectively.
V81365	SARS-CoV-2/MERS Mpro-IN-2		SARS-CoV-2/MERS Mpro-IN-2 (compound 9d) is a potent major protease inhibitor of SARS-CoV-2 and MERS with IC50s of 0.21 and 0.07 µM respectively.
V99841	SARS-CoV-IN-5		SARS-CoV-IN-5 (compound 49) is a highly selective, non-peptide, non-covalent 3CLpro inhibitor with IC50 values of 38 nM, 21.1 nM, and 86 nM for SARS-CoV-1, SARS-CoV-2, and bat coronavirus WIV1, respectively.