The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52732 | Boceprevir-d9 (EBP 520-d9; SCH 503034-d9) | 1256751-11-7 | Boceprevir-d9 is the deuterium labelled form of Boceprevir. |
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V52330 | Bofutrelvir (FB2001) | 2103278-86-8 | Bofutrelvir (FB2001) is an inhibitor (blocker/antagonist) of Mpro, the main protease of SARS-CoV-2, with IC50 of 53 nM and EC50 of 0.53 μM. |
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V54380 | Bonducellpin D | 197781-85-4 | Bonducellpin D is a furanoditerpene lactone extracted from Caesarpinia minax. |
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V54389 | Burfiralimab (hzVSF-v13) | 2460809-80-5 | Burfiralimab (hzVSF-v13) is a monoclonal IgG4 antibody directed against vimentin expressed on the surface of virus-infected cells. |
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V0019 | Carmofur | 61422-45-5 | Carmofur (also known as HCFU),a derivative of fluorouracil (5-FU) which is an antimetabolite class of anticancer drug, is a novel, highly potent acid ceramidase inhibitor used in the treatment of breast and colorectal cancer. |
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V54388 | Casirivimab (REGN10933) | 2415933-42-3 | Casirivimab (REGN10933) is a human monoclonal antibody (mAb) that targets the SARS-CoV-2 virus that causes COVID-19. |
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V54413 | CDD-1733 | 2894104-33-5 | CDD-1733 is a non-covalent and non-peptide potent SARS-CoV-2 Mpro inhibitor (antagonist) with Ki of 12 nM. |
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V54408 | CDD-1819 | 2894104-40-4 | CDD-1819 is a non-covalent and non-peptide potent SARS-CoV-2 Mpro inhibitor (antagonist) with Ki of 5 nM. |
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V54432 | CDD-1845 | 2894104-50-6 | CDD-1845 is a non-covalent and non-peptide potent SARS-CoV-2 Mpro inhibitor (antagonist) with Ki of 3 nM. |
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V78704 | CDK9-IN-25 | CDK9-IN-25 (compound 4a) is an imidazopyrazine CDK9 inhibitor (IC50= 0.24 μM). | |
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V17927 | Cepharanthine | 481-49-2 | Cepharanthine is a naturally occurring biscoclaurine alkaloid with antiinflammatory and antiviral (against COVID-19) activity. |
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V78762 | Chloroquine-d4 phosphate (Chloroquine-d4 phosphate) | Chloroquine-d4 (phosphate) is the deuterated form of Chloroquine phosphate. | |
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V54035 | Chloroquine-d5 (chloroquine d5) | 1854126-41-2 | Chloroquine-d5 is the deuterium labelled form of Chloroquine. |
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V53059 | Cichoriin | 531-58-8 | Cichoriin has obvious activity against SARS-CoV-2 and may become a potential candidate substance for studying severe COVID-19. |
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V52252 | Cilgavimab (AZD-1061; COV2-2130) | 2420563-99-9 | Cilgavimab (AZD-1061; COV2-2130) is a humanized monoclonal antibody (mAb) targeting SARS-CoV-2, which can be combined with Tixagevimab to form the monoclonal antibody (mAb) combination AZD7442. |
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V52242 | Cleistanthin B (Diphyllin O-glucoside) | 30021-77-3 | Cleistanthin B (Diphyllin O-glucoside) is an orally bioactive arylnaphthylinolide glycoside. |
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V76090 | CMX990 | 2882934-64-5 | CMX990 is a SARS-CoV-2 3CL protease inhibitor. |
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V54435 | Cnicin | 24394-09-0 | Cnicin is a sesquiterpene lactone. |
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V76076 | Coronastat (NK01-63) | 2922281-15-8 | Coronastat is a potent inhibitor of the SARS-CoV-2 3CL protease. |
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V78859 | COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP) | COVID-19 Spike Protein mRNA can express COVID-19 spike protein and is suitable for detection of RNA delivery, translation efficiency, cell viability, etc. |
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