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SARS-CoV

SARS-CoV

The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.

The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.

SARS-CoV related products

Structure Cat No. Product Name CAS No. Product Description
E07 aptamer V79233 E07 aptamer SARS-CoV-2 nsp14-IN-4 (Compound 12q) is a selective inhibitor of SARS-CoV-2 nsp14 methyltransferase with IC50 of 19 ± 2.5 nM.
EIDD-1931（β-d-N4-羟基胞苷；NHC） V39191 EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) 3258-02-4 EIDD-1931(EIDD1931; Beta-d-N4-hydroxycytidine; NHC) is anovel and potentribonucleoside analog with antiviral activity.
EIDD-2749 (4'-FlU; 4'-Fluorouridine) V52132 EIDD-2749 (4'-FlU; 4'-Fluorouridine) 1613589-24-4 EIDD-2749 (4'-Fluorouridine) is an orally bioavailable RdRp inhibitor.
Elopiprazole V85205 Elopiprazole 115464-77-2
Ensitrelvir fumarate V60009 Ensitrelvir fumarate 2757470-18-9 Ensitrelvir fumarate (S-217622 fumarate; Xocova) is a novel and orally bioavailable SARS-CoV-2 3CL protease inhibitor (IC50=13 nM) approval in Japanunder the emergency regulatory approval system (EUA) for COVID-19 treatment.
Enuzovimab V91726 Enuzovimab 2531098-91-4 Enuzovimab is a humanized IgG4 κ monoclonal antibody against SARS-CoV-2.
F594-1001 V92159 F594-1001 1215326-44-5 F594-1001 (compound 6) is a potent and highly selective SARS-CoV-2 Mac1-ADP-ribose inhibitor with IC50 of 8.5 μM, 68 μM and 45 μM for SARS-CoV-2 in AS, FP and FRET assays, respectively.
F594-1001 hydrochloride V89716 F594-1001 hydrochloride F594-1001 (compound 6) hydrochloride is a potent and highly selective SARS-CoV-2 Mac1-ADP-ribose inhibitor with IC50 of 8.5 μM, 68 μM and 45 μM for SARS-CoV-2 in AS, FP and FRET assays, respectively.
FASN-IN-4 tosylate V52097 FASN-IN-4 tosylate 2095432-57-6 FASN-IN-4 tosylate is a highly effective fatty acid synthase FASN inhibitor (antagonist) with IC50 of 10 nM (WO2012064642A1, compound 29).
FGA145 V83702 FGA145
FLDKFNHEAEDLFYQSSL V106260 FLDKFNHEAEDLFYQSSL FLDKFNHEAEDLFYQSSL is an 18-residue peptide that binds to the SARS-CoV-2 receptor binding domain (RBD).
Fluphenazine-d8 V52632 Fluphenazine-d8 1323633-98-2 Fluphenazine-d8 is a deuterated marker of Fluphenazine.
FOY-251 HCl V28295 FOY-251 HCl FOY 251 HCl is a Camostat metabolite withanti-proteolytic activity, and acts as a proteinase inhibitor.
Furin-IN-2 V87444 Furin-IN-2 Furin-IN-2 (compound P3) is a potent furin inhibitor with IC50 of 35 μM.
Gallinamide A V54399 Gallinamide A 1208232-55-6 Gallinamide A is a potent inhibitor of cathepsin L with IC50 of 17.6 pM.
Garcinone B V54393 Garcinone B 76996-28-6 Garcinone B is a xanthone analogue, a naturally occurring compound that can be extracted from the peel of mangosteen.
GC-78-HCl V86212 GC-78-HCl 3022242-53-8
GC373 V99019 GC373 1429218-54-1 GC373 is a potent SARS-CoV-2 Mpro inhibitor that blocks viral replication with an IC50 of 0.4 μM.
GRL-0496 V52044 GRL-0496 1087243-14-8 GRL-0496 is a potent clopyridine-derived SARS-CoV 3CLpro inhibitor (antagonist) with IC50 of 30 nM.
GRL-1720 V52043 GRL-1720 2835511-03-8 GRL-1720 is a potent SARS-CoV-2 Mpro inhibitor (antagonist) with EC50 of 15 µM.
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