The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76081 | Isorhamnetin 7-O-α-L-rhamnoside | 17331-72-5 | Isorhamnetin 7-O-α-L-rhamnoside has affinity to the main protease of COVID-19. |
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V54436 | Jaceidin triacetate | 14397-69-4 | Jaceidin triacetate (compound 54) is a natural compound extracted from the bark of the marula tree. |
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V89718 | Jobosic acid | 223611-93-6 | Jobosic acid, a saturated fatty acid, is a selective SARS-CoV-2 inhibitor. |
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V85896 | Jun11165 | ||
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V85728 | Jun12682 | ||
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V103721 | Jun13728 | Jun13728 is a potent covalent SARS-CoV-2 papain-like protease inhibitor with IC50 of 0.1 μM. | |
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V101136 | Jun9-72-2 | 2657659-42-0 | Jun9-72-2 is a papain (Plpro) inhibitor of SARS-CoV-2 with an IC50 value of 0.67 μM. |
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V99885 | JZD-07 | 2917528-98-2 | JZD-07 is a potent SARS-CoV 3CLpro inhibitor. |
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V54431 | Kansuinine B (kansuinine ester B) | 57685-46-8 | Kansuinine B inhibits IL-6-induced activation. |
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V52776 | Ketotifen-d3 fumarate | 1795138-23-6 | Ketotifen-d3 (fumarate) is the deuterated form of Ketotifen fumarate. |
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V106030 | Koenine | 28200-63-7 | Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (Mpro) and can be used in the research of anti-new coronavirus drugs. |
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V51891 | KW-8232 | 217813-15-5 | KW-8232 is an orally bioactive anti-osteoporotic agent that reduces the biosynthesis of prostaglandin PGE2. |
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V34654 | Ledipasvir hydrochloride (GS-5885 hydrochloride) | 2128695-48-5 | Ledipasvir (GS-5885) HCl is a potent HCV (hepatitis C virus) NS5A inhibitor that can suppress GT1a and GT1b replicons with EC50s of 34 pM and 4 pM, respectively. |
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V52719 | Ledipasvir-d6 (GS-5885-d6) | 2050041-12-6 | Ledipasvir-d6 is the deuterium labelled form of Ledipasvir. |
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V51871 | Leritrelvir (RAY1216) | 2923310-64-7 | Leritrelvir (RAY1216) is an orally bioactive slow inhibitor of the major SARS-CoV-2 protease with Ki of 8.6 nM. |
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V104481 | Limnetrelvir | 2923500-04-1 | Limnetrelvir (ABBV-903) is an MPro inhibitor. |
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V52605 | Lopinavir-d8 | 1224729-35-4 | Lopinavir-d8 is the deuterium labelled form of Lopinavir. |
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V104926 | LU9 | LU9 is a potent 3CLpro inhibitor with an IC50 value of 0.34 µM. | |
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V23686 | LY1 | 2883813-32-7 | LY1 is a potent and specific covalent inhibitor against SARS-CoV-2 PLpro and Mpro, with Kds of 1.5 μM and 2.3 μM for Mpro C145A protein and PLpro C111A protein, respectively. |
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V76089 | M56-S2 iodide | 1101867-17-7 | M56-S2 iodide is a SARS-CoV-2 Mpro inhibitor (IC50=4.0 μM). |
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