The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
![Hydroxychloroquine Impurity E (4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol)](http://www.invivochem.com/upload/1124/hy-131262.png)
|
V54418 | Hydroxychloroquine Impurity E (4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol) | 10500-64-8 | Hydroxychloroquine Impurity E is an impurity of Hydroxychloroquine. |
|
V52588 | Hydroxychloroquine-d4 sulfate (HCQ-d4 (sulfate)) | 1854126-45-6 | Hydroxychloroquine-d4 (sulfate) is the deuterated form of Hydroxychloroquine sulfate. |
|
V52589 | Hydroxychloroquine-d4-1 sulfate (hydroxychloroquine d4 (sulfate) (deuterium on the alkyl group)) | 1216432-56-2 | Hydroxychloroquine-d4-1 (sulfate) is the deuterated form of Hydroxychloroquine. |
|
V80336 | Hydroxychloroquine-d5 (hydroxychloroquine-d5; hydroxychloroquine-d5) | Hydroxychloroquine-d5 is the deuterated form of Hydroxychloroquine. | |
|
V54410 | Ibuzatrelvir (PF-07817883) | 2755812-39-4 | Ibuzatrelvir (PF-07817883) is an antiviral compound that targets the SARS-CoV-2 3CL protease. |
|
V52549 | Imatinib-d3 hydrochloride (STI571-d3 (hydrochloride); CGP-57148B-d3 (hydrochloride)) | 1134803-18-1 | Imatinib-d3 ( HCl) is the deuterated form of Imatinib. |
|
V54378 | Imdevimab (REGN10987) | 2415933-40-1 | Imdevimab (REGN10987) is a human monoclonal antibody (mAb) that targets the SARS-CoV-2 virus that causes COVID-19. |
|
V80220 | Imiquimod-d6 (R 837-d6) | Imiquimod-d6 is the deuterium labelled form of Imiquimod. | |
|
V51943 | Ipomoeassin F (Ipom-F) | 915392-44-8 | Ipomoeassin F is a potent and specific inhibitor of endoplasmic reticulum (ER) protein translocation by targeting the pore-forming subunit of the Sec61 complex (Sec61α) on the ER membrane. |
|
V54407 | Isomitomycin A | 91917-64-5 | Isomitomycin A is a potential inhibitor against SARS-CoV-2. |
|
V76081 | Isorhamnetin 7-O-α-L-rhamnoside | 17331-72-5 | Isorhamnetin 7-O-α-L-rhamnoside has affinity to the main protease of COVID-19. |
|
V54436 | Jaceidin triacetate | 14397-69-4 | Jaceidin triacetate (compound 54) is a natural compound extracted from the bark of the marula tree. |
|
V85896 | Jun11165 | ||
|
V85728 | Jun12682 | ||
|
V54431 | Kansuinine B (kansuinine ester B) | 57685-46-8 | Kansuinine B inhibits IL-6-induced activation. |
|
V52776 | Ketotifen-d3 fumarate | 1795138-23-6 | Ketotifen-d3 (fumarate) is the deuterated form of Ketotifen fumarate. |
|
V51891 | KW-8232 | 217813-15-5 | KW-8232 is an orally bioactive anti-osteoporotic agent that reduces the biosynthesis of prostaglandin PGE2. |
|
V34654 | Ledipasvir hydrochloride (GS-5885 hydrochloride) | 2128695-48-5 | Ledipasvir (GS-5885) HCl is a potent HCV (hepatitis C virus) NS5A inhibitor that can suppress GT1a and GT1b replicons with EC50s of 34 pM and 4 pM, respectively. |
|
V52719 | Ledipasvir-d6 (GS-5885-d6) | 2050041-12-6 | Ledipasvir-d6 is the deuterium labelled form of Ledipasvir. |
|
V54374 | Lenzilumab (KB 003) | 1229575-09-0 | Lenzilumab (KB 003) is a humanized monoclonal antibody (mAb) targeting CSF2/GM-CSF for use in COVID-19, chronic myelomonocytic leukemia (CMML), and juvenile myelomonocytic leukemia (JMML). |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
