The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V80847 | MTase-IN-1 | MTase-IN-1 (compound 26) is a potent and specific inhibitor of coronavirus nsp14 N7-methyltransferase with IC50 of 0.72 nM. | |
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V103619 | MTDB-Alkyne | 2923694-73-7 | MTDB-Alkyne is an alkyne-containing click chemistry reagent. |
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V93104 | MTI013 | MTI013 is a selective SARS-CoV-2 nsp14 Mtase inhibitor (IC50: 2.98 μM) and antiviral agent (IC50 10.33 μM in HCoV-229E-infected Huh7 cells). | |
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V79898 | Nafamostat formate salt-13C6 (Nafamostat formate salt-13C6) | Nafamostat formate salt-13C6 is 13C (carbon 13) labelled Nafamostat. | |
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V104389 | NCGC00537446 | NCGC00537446 is a dual Nsp14 MTase/ExoN inhibitor. | |
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V41115 | Nepuvibart (ZRC3308-B10) | 2640224-48-0 | Nepuvibart (ZRC3308-B10) is a monoclonal antibody (mAb) (IgG1 type) targeting SARS-CoV-2. |
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V51965 | NHC-diphosphate | 39023-73-9 | NHC-diphosphate is the active intracellular metabolite of NHC and exists in the form of diphosphate. |
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V103857 | NIP-22c | 2309384-85-6 | NIP-22c is a novel coronavirus 3CLpro inhibitor with EC50 of 4.6, 1.1, 0.1, and 0.6 μM for Verona, Calu3, Caco2, and HBTEC-ALI, respectively. |
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V101428 | Nisfevitug | Nisfevitug is a human IgG1 kappa monoclonal antibody against SARS-CoV-2. | |
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V54405 | NK007 | 2488661-53-4 | NK007 is a novel anti-SARS-CoV-2 active molecule with EC50 of 30 nM. |
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V106194 | NQK-A8 peptide | The NQK-A8 peptide is an immunodominant peptide of the seasonal coronaviruses HKU1-CoV and OC43-CoV. | |
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V106193 | NQK-Q8 peptide | 2445453-91-6 | The NQK-Q8 peptide is an immunodominant peptide of SARS-Cov-2. |
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V80974 | NSC89641 | NSC89641 inhibits MERS-CoV Mpro with IC50 < 3.5 μM. | |
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V88332 | nsp12-IN-1 | Nsp12-IN-1 is a nucleoside analog. | |
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V104965 | NZ-804 | 2858658-44-1 | NZ-804 is an orally active primary SARS-CoV-2 protease Mpro inhibitor with IC50 of 8.9 nM. |
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V54384 | Ogalvibart (C-135-LS; BMS-986414) | 2599039-60-6 | Ogalvibart (C-135-LS) is a humanized anti-SARS-CoV-2 monoclonal antibody (mAb) (IgG1 type). |
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V85525 | Olgotrelvir sodium (STI-1558 sodium) | 2763596-72-9 | |
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V106311 | P315V3 | P315V3 is a pan-coronavirus inhibitor that inhibits SARS-CoV-2 prototype PT, Delta, BA.1, and BA.4 strains with IC50 of 10.9, 8.9, 8.6, and 2.7 nM, respectively. | |
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V104581 | PAMAM dendrimer G1.5 carboxylate sodium | 251970-28-2 | PAMAM Dendrimer G1.5 Carboxylate Sodium (PAMAM G1.5 Carboxylate) is a polyanionic dendrimer composed of sodium terminal carboxylates. |
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V88333 | PAV-104 | 2923674-83-1 | PAV-104 inhibits SARS-CoV-2 replication at an MOI of 0.01. |
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