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SARS-CoV

SARS-CoV

The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.

The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.

SARS-CoV related products

Structure Cat No. Product Name CAS No. Product Description
(25S)-Antcin B V76093 (25S)-Antcin B 1312711-71-9 Antcin-B is a potent inhibitor of 3CLPro with high affinity.
(H)S(OMe)-DFR-kbt V121821 (H)S(OMe)-DFR-kbt (H)S(OMe)-DFR-kbt is a potent and selective TMPRSS2 inhibitor with a Ki value of 0.13 nM.
(M)-AVI-4773 V121827 (M)-AVI-4773 3111610-68-2 (M)-AVI-4773 is an orally effective, blood-brain barrier-crossing coronavirus MPro inhibitor with an IC50 of 2.5 nM against SARS-CoV-2 MPro.
(R)-Danshensu sodium (Dan shen suan A sodium; Salvianic acid A sodium) V85797 (R)-Danshensu sodium (Dan shen suan A sodium; Salvianic acid A sodium) 81075-52-7
(Rac)-X77 V35118 (Rac)-X77 2144491-78-9 (Rac)-X77 is the racemate of X77.
(S)-Azelastine hydrochloride V94974 (S)-Azelastine hydrochloride 153408-27-6 (S)-Azelastine hydrochloride belongs to the antihistamine class and is a potent and selective histamine 1 (H1) antagonist.
(S)-GS-621763 V122171 (S)-GS-621763 2563617-99-0 (S)-GS-621763 is the S-enantiomer of GS-621763.
(S)-ML188 V122194 (S)-ML188 1417700-12-9 (S)-ML188 is a SARS-CoV 3-chymotrypsin-like protease (3CLpro) inhibitor (IC50: 1.5 μM).
(S)-Velpatasvir-13C,d3 V122228 (S)-Velpatasvir-13C,d3 (S)-Velpatasvir-13C,d3 is 13C-labeled Velpatasvir.
(±)-Alliin ((±)-L-Alliin) V35040 (±)-Alliin ((±)-L-Alliin) 17795-26-5 (±)-Alliin is the main active ingredient of garlic.
1 V91698 1"-α-Azido-RDPr 1"-α-Azido-RDPr (Compound 11) is an adenosine diphosphate ribose analogue, which inhibits the SARS-CoV-2 nonstructural protein macromolecular domain SARS-CoV-2 NSP3 Mac1 with IC50 of 30 nM.
1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one V54426 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one 149732-52-5 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent inhibitor of N protein and can be extracted from Curcuma kwangsiensis.
10-Hydroxyaloin A V54424 10-Hydroxyaloin A 134863-91-5 10-Hydroxyaloin A is a potent SARS-CoV-2 inhibitor.
13-TP V123185 13-TP 13-TP is a SARS-CoV-2 inhibitor.
13-TP prodrug V123186 13-TP prodrug 13-TP prodrug is a potent and orally effective anti-SARS-CoV-2 drug.
2'-RIBOTAC-U V102162 2'-RIBOTAC-U 2'-RIBOTAC-U is a chimeric (RIBOTAC) targeted ribonuclease (RNase) and SARS-CoV-2 replication inhibitor.
2,5-Dimethylcyclohexanol V115493 2,5-Dimethylcyclohexanol 3809-32-3 2,5-Dimethylcyclohexanol is a volatile organic compound belonging to the fatty acid family, isolated from the genus Amphora sp.
2-Chloro-2′-deoxyadenosine monophosphate V116756 2-Chloro-2′-deoxyadenosine monophosphate 104959-32-2 2-Chloro-2′-deoxyadenosine monophosphate is an anti-coronavirus drug.
2-Hydroxyacetophenone (2-羟基苯乙酮; Phenacyl alcohol) V52905 2-Hydroxyacetophenone (2-Hydroxyacetophenone; Phenacyl alcohol) 582-24-1 2-Hydroxyacetophenone is the major root volatile of Carissa edulis.
2-Hydroxycinnamic acid ((E)-3-(2-羟基苯基)丙烯酸) V53006 2-Hydroxycinnamic acid ((E)-3-(2-hydroxyphenyl)acrylic acid) 614-60-8 2-Hydroxycinnamic acid is extracted from the methanolic extract of cinnamon.
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