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Apoptosis

Apoptosis

Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.

There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.

Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.

Apoptosis related products

Structure Cat No. Product Name CAS No. Product Description
Bim BH3 V54940 Bim BH3 505070-06-4 Bim BH3 is a biologically active peptide.
Biotin-COG1410 TFA V77202 Biotin-COG1410 TFA Biotin-COG1410 TFA is biotinylated COG1410.
Biotin-DEVD-CHO V54964 Biotin-DEVD-CHO 178603-73-1 Biotin-DEVD-CHO can be used for affinity labeling of caspase-8 after Caspase-8 cleavage in vitro.
Bisabosqual A V84580 Bisabosqual A 180027-46-7
Bisdemethoxycurcumin-d8 (Curcumin III-d8; Didemethoxycurcumin-d8) V56395 Bisdemethoxycurcumin-d8 (Curcumin III-d8; Didemethoxycurcumin-d8) 2470233-08-8 Bisdemethoxycurcumin-d8 is the deuterium labelled form of Bisdemethoxycurcumin.
BK60106 V80177 BK60106 BK60106 is a CD99 inhibitor that directly binds to the extracellular domain of CD99.
Bleomycin A5 (Pingyangmycin) V35075 Bleomycin A5 (Pingyangmycin) 11116-32-8 Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with oral activity.
Blisibimod (A 623; AMG 623) V52338 Blisibimod (A 623; AMG 623) 1236126-45-6 Blisibimod (A 623) is a potent and specific tetravalent B-cell activating factor (BAFF) inhibitor.
BM-1197 (UBX1967) V52337 BM-1197 (UBX1967) 1391107-89-3 BM-1197 (UBX1967) is a potent and specific dual Bcl-2/Bcl-xL inhibitor (antagonist) with IC50s of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-xL inhibition, respectively.
BM-1244 (APG-1252-M1) V52938 BM-1244 (APG-1252-M1) 1619923-32-8 BM-1244 (APG-1252-M1) is a potent Bcl-xL/Bcl-2 inhibitor (antagonist) with Ki of 134 and 450 nM for Bcl-xL and Bcl-2, respectively.
BMf-BH3 (BMF-Y) V78488 BMf-BH3 (BMF-Y) BMf-BH3 (BMF-Y) belongs to the Bcl-2 family of apoptotic mediators.
BMS 310705 (21-Aminoepothilone B) V52335 BMS 310705 (21-Aminoepothilone B) 280578-49-6 BMS 310705 (21-Aminoepothilone B) is an analog of Epothilone B , targeting malignant tumors such as ovarian cancer, kidney cancer, bladder cancer and lung cancer.
Boc-AEVD-CHO V54862 Boc-AEVD-CHO 220094-15-5 Boc-AEVD-CHO is a Caspase 8 inhibitor that may be utilized in the study of apoptosis as well as immune and inflammatory diseases.
Boc-Ala-Ala-Asp-pNA V54954 Boc-Ala-Ala-Asp-pNA 201732-83-4 Boc-Ala-Ala-Asp-pNA is a chromogenic substrate for granzyme B.
Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) V52331 Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) 187389-53-3 Boc-Asp(OME)-Fluoromethyl Keton is a broad caspase inhibitor that can suppress Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.
BODIPY 581/591 C11 V35064 BODIPY 581/591 C11 217075-36-0 BODIPY 581/591 C11 is a BODIPY fluoroboronide analogue with good photostability and low fluorescence artifacts.
BPU V85261 BPU
bpV(phen) trihydrate V32160 bpV(phen) trihydrate 171202-16-7 bpV(phen) trihydrate, an insulin mimetic, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (antagonist) with IC50s of 38 nM, 343 nM and PTEN for PTEN, PTP-β and PTP-1B.
BQZ-485 V54872 BQZ-485 1906915-49-8 BQZ-485 is a potent GDI2 inhibitor by interacting with Tyr245.
BRD1991 V52327 BRD1991 2235468-02-5 BRD1991 selectively disrupts Beclin 1/Bcl-2 binding, inducing autophagy without triggering apoptosis or other forms of cell death.
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