Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V35075 | Bleomycin A5 (Pingyangmycin) | 11116-32-8 | Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with oral activity. |
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V52338 | Blisibimod (A 623; AMG 623) | 1236126-45-6 | Blisibimod (A 623) is a potent and specific tetravalent B-cell activating factor (BAFF) inhibitor. |
|
V52337 | BM-1197 (UBX1967) | 1391107-89-3 | BM-1197 (UBX1967) is a potent and specific dual Bcl-2/Bcl-xL inhibitor (antagonist) with IC50s of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-xL inhibition, respectively. |
|
V52938 | BM-1244 (APG-1252-M1) | 1619923-32-8 | BM-1244 (APG-1252-M1) is a potent Bcl-xL/Bcl-2 inhibitor (antagonist) with Ki of 134 and 450 nM for Bcl-xL and Bcl-2, respectively. |
|
V78488 | BMf-BH3 (BMF-Y) | BMf-BH3 (BMF-Y) belongs to the Bcl-2 family of apoptotic mediators. | |
|
V52335 | BMS 310705 (21-Aminoepothilone B) | 280578-49-6 | BMS 310705 (21-Aminoepothilone B) is an analog of Epothilone B , targeting malignant tumors such as ovarian cancer, kidney cancer, bladder cancer and lung cancer. |
|
V54862 | Boc-AEVD-CHO | 220094-15-5 | Boc-AEVD-CHO is a Caspase 8 inhibitor that may be utilized in the study of apoptosis as well as immune and inflammatory diseases. |
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V54954 | Boc-Ala-Ala-Asp-pNA | 201732-83-4 | Boc-Ala-Ala-Asp-pNA is a chromogenic substrate for granzyme B. |
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V52331 | Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) | 187389-53-3 | Boc-Asp(OME)-Fluoromethyl Keton is a broad caspase inhibitor that can suppress Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8. |
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V35064 | BODIPY 581/591 C11 | 217075-36-0 | BODIPY 581/591 C11 is a BODIPY fluoroboronide analogue with good photostability and low fluorescence artifacts. |
|
V85261 | BPU | ||
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V32160 | bpV(phen) trihydrate | 171202-16-7 | bpV(phen) trihydrate, an insulin mimetic, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (antagonist) with IC50s of 38 nM, 343 nM and PTEN for PTEN, PTP-β and PTP-1B. |
|
V54872 | BQZ-485 | 1906915-49-8 | BQZ-485 is a potent GDI2 inhibitor by interacting with Tyr245. |
|
V3417 | Brassinolide | 72962-43-7 | Brassinolide, a plant growth modulator and a plant hormone, is a sterol compound first isolated from pollen of rape (Brassica napus L.). |
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V52327 | BRD1991 | 2235468-02-5 | BRD1991 selectively disrupts Beclin 1/Bcl-2 binding, inducing autophagy without triggering apoptosis or other forms of cell death. |
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V52326 | BRD4/CK2-IN-1 | 2756851-99-5 | BRD4/CK2-IN-1 is the first highly effective, orally bioactive BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2) dual-target inhibitor. |
|
V53251 | Bromelain (bromelain) | 9001-00-7 | Bromelain is an anti-inflammatory agent derived from pineapple stems, which works by downregulating plasma kininogen, inhibiting prostaglandin E2 expression, degrading advanced glycation end product receptors, modulating angiogenic biomarkers, and inducing resistance upstream of the COX pathway. |
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V54907 | Bromoiodoacetamide | 62872-36-0 | Bromoiodoacetamide is an iodinated haloamide (I-HAcAms) that is cytotoxic. |
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V52321 | Broussochalcone A | 99217-68-2 | Broussochalcone A is an antioxidant and xanthine oxidase inhibitor (IC50=2.21 μM) with free radical scavenging activity. |
|
V17150 | Bruceine D | 21499-66-1 | Bruceine D is a Notch inhibitor (antagonist) with anti-cancer effect and causes apoptosis in several human cancer/tumor cells. |
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