Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V54830 | BTM-3528 | 2054998-45-5 | BTM-3528 is an activator of the mitochondrial protease OMA1 and mediates excessive activation of the mitochondrial integrated stress response (ISR). |
|
V54820 | BTM-3566 | 2228857-70-1 | BTM-3566 is an OMA1 activator. |
|
V32158 | BTR-1 | 18331-34-5 | BTR-1 is an active anti-cancer compound that can induce cell cycle S-phase arrest and affect DNA replication. |
|
V17181 | BTZO-1 | 99420-15-2 | BTZO-1, a cardioprotective compound, is a novel and potent activator of the glutathione S-transferase Ya subunit (GST Ya) gene-antioxidant response element (ARE) by interacting with MIF, it binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. |
|
V35069 | Bufarenogin | 17008-65-0 | Bufarenogin causes apoptosis through Bax and ANT. |
|
V30491 | Bufotalin | 471-95-4 | Bufotalin is a steroid lactone extracted from Venenum Bufonis with potent anti-tumor effects. |
|
V52310 | Bursehernin (Methylpluviatolide) | 40456-51-7 | Bursehernin (Methylpluviatolide) is an antineoplastic/anticancer agent. |
|
V56458 | Butylated hydroxytoluene-d21 (2,6-di-tert-butyl-p-cresol-d21) | 64502-99-4 | Butylated hydroxytoluene-d21 is the deuterated form of Butylated hydroxytoluene. |
|
V56454 | Butylated hydroxytoluene-d24 (2,6-di-tert-butyl-p-cresol-d24) | 1219805-92-1 | Butylated hydroxytoluene-d24 is the deuterated form of Butylated hydroxytoluene. |
|
V56452 | Butylated hydroxytoluene-d3 (2,6-di-tert-butyl-p-cresol-d3) | 86819-59-2 | Butylated hydroxytoluene-d3 is the deuterated form of Butylated hydroxytoluene. |
|
V2935 | C-DIM12 | 178946-89-9 | C-DIM12 is a novel, phytochemical-based and synthetic small molecule Nurr1 activator that has neuroprotective activities. |
|
V56435 | c-JUN peptide | 610273-01-3 | c-JUN peptide is a cell-penetrating/penetrable inhibitor of c-JUN-JNK interaction. |
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V85051 | c-Met-IN-22 | ||
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V54944 | c-Myc inhibitor 10 | 2299227-75-9 | c-Myc inhibitor 10 (compound 17) is an inhibitor (blocker/antagonist) of c-myc and displays certain cellular potency consistent with increased permeability of methylated morpholine nitrogen. |
|
V54946 | c-Myc inhibitor 4 | 2763366-92-1 | c-Myc inhibitor 4 is a potent orally bioavailable c-MYC-reducing compound. |
|
V52236 | c-Myc inhibitor 6 | 2768765-58-6 | c-Myc inhibitor 6 (compound A102) is a c-Myc inhibitor. |
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V52235 | c-Myc inhibitor 7 | 2883535-99-5 | c-Myc inhibitor 7 is a c-Myc inhibitor and multi-target protein degrader. |
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V52233 | c-Myc inhibitor 8 | 2173505-97-8 | c-Myc inhibitor 8 (compound 56) is a c-Myc inhibitor. |
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V52234 | c-Myc inhibitor 9 | 2799717-96-5 | c-Myc inhibitor 9 is a c-Myc inhibitor (antagonist) with logEC50 ≥6. |
|
V52308 | C24:1-Ceramide | 54164-50-0 | C24:1-Ceramide is one of the most abundant naturally occurring ceramides. |
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