Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V54991 | C5 Lenalidomide (Lenalidomide 5'-amine) | 191732-70-4 | C5 Lenalidomide (Lenalidomide 5'-amine) is a thalidomide analog that is generated by TNF-alpha (IC50=100μM in LPS-stimulated human PBMC). |
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V52773 | Cabozantinib-d6 (XL184-d6; BMS-907351-d6) | 1802168-46-2 | Cabozantinib-d6 is the deuterated form of Cabozantinib. |
|
V78601 | Cadein1 | Cadein1 is an isoquinoline analogue that causes G2/M delay and caspase-dependent apoptosis in cancer/tumor cells with loss of p53 function. | |
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V78604 | Caerin 1.1 TFA | Caerin 1.1 TFA is a host defense peptide extracted from the glandular secretions of the Australian tree frog Litoria. | |
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V52305 | Calcimycin hemimagnesium (A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium) | 72124-77-7 | Calcimycin (A-23187) hemimagnesium is an antibiotic and unique divalent cation ionophore, such as calcium and magnesium ions. |
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V53418 | Calphostin C (UCN-1028C) | 121263-19-2 | Calphostin C is a potent and specific inhibitor of protein kinase C. |
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V16921 | Calycosin | 20575-57-9 | Calycosin is a natural compound with antioxidant and anti~inflammatory activity. |
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V52304 | CAM833 | 2758364-02-0 | CAM833 is a potent orthotopic inhibitor of the interaction between BRCA2 and RAD51, with a Kd of 366 nM for ChimRAD51 protein. |
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V52302 | Canfosfamide (TLK-286; TER286) | 158382-37-7 | Canfosfamide (TLK-286) is a glutathione analog prodrug that is activated by glutathione S-transferase P1-1 and causes apoptosis. |
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V56426 | Capecitabine-d11 (Capecitabine d11) | 1132662-08-8 | Capecitabine-d11 is the deuterated form of Capecitabine. |
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V56391 | Capsaicin-d3 ((E)-Capsaicin-d3) | 1217899-52-9 | Capsaicin-d3 is the deuterated form of Capsaicin. |
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V4898 | Carubicin | 50935-04-1 | Carubicin (Karminomitsin; Carminomicin I;karminomycin; Demethyldaunomycin), a potent anticancer agent and DNA intercalator, is a natural anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. |
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V17602 | Carubicin HCl | 52794-97-5 | Carubicin HCl (Karminomitsin; karminomycin; Carminomicin I; Demethyldaunomycin), the hydrochloride salt ofCarubicin, is a naturally occurring anthracycline antineoplastic antibioticisolated from the bacterium Actinomadura carminata. |
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V27805 | Casein Kinase inhibitor A51 | 2079068-74-7 | Casein Kinase inhibitor A51 is a potent and orally bioactive casein kinase 1α (CK1α) inhibitor. |
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V34811 | Casein Kinase inhibitor A86 | 2079069-01-3 | Casein Kinase inhibitor A86 is a potent and orally bioactive casein kinase 1α (CK1α) inhibitor. |
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V78715 | Caspase-3/7 activator 1 | Caspase-3/7 activator 1 is a potent Caspase-3/7 activator. | |
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V78651 | Caspase-3/7 activator 2 | Caspase-3/7 activator 2 is a potent Caspase-3/7 activator. | |
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V79106 | Caspase-3/7 activator 3 | Caspase-3/7 activator 3 is a potent Caspase-3/7 activator. | |
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V52298 | Caspase-9 Inhibitor III (Ac-LEHD-cmk) | 403848-57-7 | Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a caspase-9 inhibitor. |
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V84579 | CBR1-IN-6 |
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