Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V54101 | Cinchonine monohydrochloride hydrate ((8R,9S)-Cinchonine monohydrochloride hydrate; LA40221 monohydrochloride hydrate) | 206986-88-1 | Cinchonine ((8R,9S)-Cinchonine) mono HCl hydrate is a natural compound that has been effectively used as an antimalarial agent. |
|
V52530 | Cinnabarinic acid (cinnabaric acid) | 606-59-7 | Cinnabarinic acid is an mGlu4-specific allosteric agonist that can interact with the glutamate-binding pocket residues of mGlu4 and has no activity on other mGlu receptor subtypes. |
|
V52249 | Cinrebafusp alfa (PRS 343) | 2218515-90-1 | Cinrebafusp alfa (PRS 343) is a high-affinity CD137/HER2 bispecific anticalcin drug. |
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V54974 | cis,trans-Germacrone | 32663-51-7 | cis,trans-Germacrone is an isomer of Germacrone . |
|
V52247 | cis-Clovamide | 53755-03-6 | cis-Clovamide, a natural phenolic compound with antioxidant, anti~inflammatory and anti-apoptotic activities. |
|
V56324 | Citric acid-13C3 (citric acid-13C3) | 302912-06-7 | Citric acid-13C3 is 13C (carbon 13) labelled Citric acid. |
|
V52795 | Citric acid-13C6 (citric acid 13C6) | 287389-42-8 | Citric acid-13C6 is a 13C (carbon 13)-labeled Citric acid. |
|
V52796 | Citric acid-d4 (citric acid d4) | 147664-83-3 | Citric acid-d4 is the deuterated form of Citric acid. |
|
V52243 | CLEFMA | 1246964-32-8 | CLEFMA is a curcumin with anti-tumor effects. |
|
V53132 | Cleomiscosin A | 76948-72-6 | Cleomiscosin A is a coumarin lignin produced in Macaranga adenantha. |
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V54475 | Clezutoclax | 1949843-71-3 | Clezutoclax is a payload and a Bcl-XL inhibitor. |
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V52238 | CMLD-2 | 958843-91-9 | CMLD-2 is an inhibitor (blocker/antagonist) of the HuR-ARE interaction. |
|
V54819 | CMLD010509 (SDS-1-021) | 256497-58-2 | CMLD010509 (SDS-1-021) is a specific inhibitor that supports the oncogenic translation program in multiple myeloma (MM)such as key oncoproteins such as MYC, MDM2, CCND1, MAF and MCL-1. |
|
V52232 | Coelonin | 82344-82-9 | Coelonin is a dihydrophenanthrene with anti-inflammatory activity. |
|
V56446 | Coenzyme Q10-d9 (CoQ10-d9; Ubiquinone-10-d9) | 2687960-97-8 | Coenzyme Q10-d9 is the deuterium labelled form of Coenzyme Q10. |
|
V52230 | Coibamide A | 1029227-48-2 | Coibamide A is an N-methyl stabilized cytotoxic depsipeptide with potent antiproliferation activity. |
|
V56423 | Colchicine-d3 (colchicine d3) | 1217625-62-1 | Colchicine-d3 is the deuterated form of Colchicine. |
|
V52586 | Colchicine-d6 (colchicine d6) | 1217651-73-4 | Colchicine-d6 is the deuterated form of Colchicine. |
|
V52229 | Colivelin TFA | 2803948-60-7 | Colivelin TFA is a neuro-protection peptide with brain permeability and an effective activator of STAT3. |
|
V52226 | Conatumumab (AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody) | 896731-82-1 | Conatumumab (AMG 655) is a monoclonal agonist antibody directed against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for long DR5, 0.8 nM for short DR5). |
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