Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54909 | Condurango glycoside A | 11051-90-4 | Condurango glycoside A is an activator of p53. |
|
V52225 | Conglobatin (FW-04-806) | 72263-05-9 | Conglobatin (FW-04-806) is a macrolide dilactone extracted from cultures of Streptomyces conglobatus. |
|
V54857 | CPT-Se3 | 2968315-02-6 | CPT-Se3 is a selenium-containing precursor active molecule of camptothecin (CPT) that displays higher potency in killing cancer cells and inhibiting tumor growth. |
|
V54897 | CPT-Se4 | 2968315-03-7 | CPT-Se4 is a selenium-containing precursor active molecule of camptothecin (CPT) that displays higher potency in killing cancer cells and inhibiting tumor growth. |
|
V54878 | CPT2 (Carnitine palmitoyltransferase 2) | 1670277-66-3 | CPT2 (Carnitine palmitoyltransferase 2) is an enzyme involved in fatty acid oxidation and a prognostic biomarker for colorectal cancer (CRC). |
|
V52223 | CPTH2 hydrochloride | 2108899-91-6 | CPTH2 HCl is a potent histone acetyltransferase (HAT) inhibitor. |
|
V52221 | CR-1-31-B | 1352914-52-3 | CR-1-31-B is a synthetic Rocaglate and a potent eIF4A inhibitor. |
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V52220 | CRA-026440 hydrochloride | 847459-98-7 | CRA-026440 HCl is a potent broad-spectrum HDAC (HDAC) inhibitor. |
|
V54918 | cRIPGBM | 2361988-76-1 | cRIPGBM is a pro-apoptotic analogue of RIPGBM. |
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V52219 | cRIPGBM chloride | 2361988-77-2 | cRIPGBM chloride is an orally bioavailable pro-apoptotic analogue, cRIPGBM is produced from glioblastoma multiforme (GBM) cancer stem cells (CSC). |
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V4649 | CU-242 (QBS) | 16082-64-7 | CU-242 (also known as QBS) is a novel and potent inhibitor of cell cycle at G2 phase; it is also apoptosis inducer. |
|
V55005 | Cudraflavone B | 19275-49-1 | Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-cancer properties. |
|
V52214 | Curcumin 5-8 (CUR5-8) | 890984-26-6 | Curcumin 5-8 (CUR5-8) is a natural active curcumin (CUR) analogue. |
|
V52213 | CWI1-2 | 2408590-36-1 | CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts. |
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V52212 | CWI1-2 hydrochloride | 2408590-37-2 | CWI1-2 HCl is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts. |
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V52211 | Cycleanine | 518-94-5 | Cycleanine is a potent vasculoselective Ca-antagonist. |
|
V52208 | Cyclo(Arg-Gly-Asp-D-Phe-Val) | 137813-35-5 | Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor. |
|
V2012 | Cyclovirobuxin D (CVB-D) | 860-79-7 | Cyclovirobuxine D (also called CVB-D; Bebuxine) is a natural and bioactive compound isolated from Buxus microphylla, which has been used for treating acute myocardial ischemia. |
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V52205 | CYD-4-61 | 1425944-33-7 | CYD-4-61 is a novel Bax activator for breast cancer research. |
|
V56405 | Cystamine-d8 (dihydrochloride) | 2712126-51-5 | Cystamine-d8 (di-HCl) is the deuterated form of Cystamine (di-HCl). |
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