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Apoptosis

Apoptosis

Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.

There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.

Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.

Apoptosis related products

Structure Cat No. Product Name CAS No. Product Description
1,6,7-Trihydroxyxanthone (1,6,7-三羟基呫吨酮) V52525 1,6,7-Trihydroxyxanthone 25577-04-2 1,6,7-Trihydroxyxanthone is a potent anticancer agent.
1-Alaninechlamydocin V54844 1-Alaninechlamydocin 141446-96-0 1-Alaninechlamydocin is a cyclic tetrapeptide and a potent HDAC inhibitor (IC50=6.4 nM).
1-Decarboxy-3-oxo-ceanothic acid (DOCA) V54831 1-Decarboxy-3-oxo-ceanothic acid (DOCA) 214150-74-0 1-Decarboxy-3-oxo-ceanothic Acid is an anti-cancer compound.
10-Formyl-5,8-dideazafolic acid V52956 10-Formyl-5,8-dideazafolic acid 61038-31-1 10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.
12-HETE (12-羟基二十碳四烯酸) V52524 12-HETE (12-hydroxyeicosatetraenoic acid) 71030-37-0 12-HETE is the major metabolite of arachidonic acid catalyzed by 12-LOX and inhibits cell apoptosis.
12-HETE-d8 V52754 12-HETE-d8 2525175-25-9 12-HETE-d8 is the deuterated form of 12-HETE.
142I5 V54906 142I5 2865171-75-9 142I5 is a potent covalent/irreversible inhibitor of ML-IAP Lys with IC50 of 11 nM.
2'-epi-2'-O-Acetylthevetin B (GHSC-74) V56434 2'-epi-2'-O-Acetylthevetin B (GHSC-74) 82145-55-9 2'-epi-2'-O-Acetylthevetin B (GHSC-74) is a cardiac glycoside that can be extracted from the seeds of Cerbera manghas L.
2'-Fucosyllactose (2'-FL) V52508 2'-Fucosyllactose (2'-FL) 41263-94-9 2'-Fucosyllactose (2'-FL) is an oligosaccharide found in breast milk.
2'-O-Methylguanosine V52987 2'-O-Methylguanosine 2140-71-8 2'-O-Methylguanosine is a modified nucleoside generated by tRNA guanosine-2'-o-methyltransferase.
2,3-DCPE V54912 2,3-DCPE 418788-90-6 2,3-DCPE can cause apoptosis and downregulate Bcl-XL expression.
2,3-DCPE hydrochloride V83690 2,3-DCPE hydrochloride 1009555-55-8
2,4,6-Triiodophenol (2,4,6-三碘酚) V52520 2,4,6-Triiodophenol (2,4,6-Triiodophenol) 609-23-4 2,4,6-Triiodophenol is an orally bioactive, potent inhibitor of leukotriene B4 (LTB4) synthesis.
2-Bromohexadecanoic acid (2-Bromopalmitic acid) V2808 2-Bromohexadecanoic acid (2-Bromopalmitic acid) 18263-25-7 2-Bromohexadecanoic acid (2-Bromopalmitic acid) is a 2-bromopalmitic acid that can be converted to 2-bromopalmitate (2-BP).
2-Chlorophenoxazine V54888 2-Chlorophenoxazine 56821-03-5 2-Chlorophenoxazine is an Akt inhibitor (antagonist) with an in vitro IC50 of 2-5 μM.
2-Hydroxy-3-methylanthraquinone (大黄素杂质16) V54913 2-Hydroxy-3-methylanthraquinone (emodin impurity 16) 17241-40-6 2-Hydroxy-3-methylanthraquinone (compound 1) is extracted from the aqueous extract of Hephiphylla alba.
2-Hydroxycinnamaldehyde (2-羟基肉桂醛) V54861 2-Hydroxycinnamaldehyde 3541-42-2 2-Hydroxycinnamaldehyde is a phenylpropanoid that can be extracted from the bark of Cinnamomum cassia.
2-Methoxyestradiol-13C,d3 (二甲氧基雌二醇 13C,d3) V56422 2-Methoxyestradiol-13C,d3 (Dimethoxyestradiol 13C,d3) 1217470-09-1 2-Methoxyestradiol-13C,d3 is a 13C- and deuterium labelled 2-Methoxyestradiol.
2-tert-Butyl-1,4-benzoquinone V54859 2-tert-Butyl-1,4-benzoquinone 3602-55-9 2-tert-Butyl-1,4-benzoquinone is the electrophilic metabolite of butylated hydroxyanisole and the oxidation product of 2-tert-butylhydroquinone.
2019-June V4717 Aloperine 56293-29-9 Aloperine is an alkaloid found in the roots ofS.
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