Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V54994 | Episappanol | 111254-18-3 | Episappanol is a natural compound extracted from the heartwood of Caesarpinia sappan that exhibits anti-inflammatory effect. |
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V52114 | Epobis | 915091-83-7 | Epobis is a dendritic peptide, a recombinant form of erythropoietin. |
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V54807 | Eriocalyxin B | 84745-95-9 | Eriocalyxin B is a diterpene compound extracted from the Chinese herbal medicine Vicella hirsutum. |
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V80062 | ERK-IN-6 | ERK-IN-6 (compound 6g) is a potent antiproliferation agent for esophageal squamous cell carcinoma (ESCC). | |
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V31091 | Ethoxysanguinarine | 28342-31-6 | Ethoxysanguinarine is a benzophenanthridine alkaloid naturally occurring compound found mainly in Macleaya cordata. |
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V52901 | Ethylene dimethanesulfonate | 4672-49-5 | Ethylene dimethanesulfonate is a mildly alkylated non-volatile methane sulfonate diester of ethylene glycol. |
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V52544 | Etidronic acid-d3 disodium (Etidronate-d3 (disodium); HEDPA-d3 (disodium); HEDP-d3 (disodium)) | 358730-93-5 | Etidronic acid-d3 (disodium) is the deuterium labelled form of Etidronic acid disodium. |
|
V56401 | Etretinate-d3 (Etretinate-d3) | 1185237-13-1 | Etretinate-d3 is the deuterium labelled form of Etretinate. |
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V52812 | Eugenol-d3 (eugenol d3) | 1335401-17-6 | Eugenol-d3 is the deuterium labelled form of Eugenol. |
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V52109 | Eupalinolide O (Eupalinolide O) | 2170228-67-6 | Eupalinolide O is a sesquiterpene lactone with anti-cancer effect. |
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V53149 | Euphorbia Factor L2 (Euphorbia Factor L2) | 218916-51-9 | Euphorbia factor L2 is an erythritane diterpene (Euphorbia lathyris L. |
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V52108 | Euphornin | 80454-47-3 | Euphornin is an anticancer agent that can be extracted from E. helioscopia. |
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V52107 | Euptox A (9-Oxo-10,11-dehydroageraphorone) | 79491-71-7 | Euptox A (9-Oxo-10, 11-dehydroageraphorone) is a cinnamon sesquiterpene and the main toxin extracted from Eupatorium adenophora. |
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V52543 | Everolimus-d4 (RAD001-d4; SDZ-RAD-d4) | 1338452-54-2 | Everolimus-d4 is the deuterium labelled form of Everolimus. |
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V34810 | Evocarpine (Evocarpine; Evocarpine; Evocarpine) | 15266-38-3 | Evocarpine is a quinolone alkaloid extracted from Evodiae fructus that can inhibit Ca2+ influx through voltage-dependent calcium channels. |
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V1875 | Evofosfamide (TH-302) | 918633-87-1 | Evofosfamide (TH-302) is potent and selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism. |
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V35034 | F1324 | 2607975-44-8 | F1324 is a potent, high-affinity peptide inhibitor of BCL6 with IC50 of 1 nM. |
![fac-[Re(CO)3(L6)(H2O)][NO3]](http://www.invivochem.com/upload/1124/V79375.png)
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V79375 | fac-[Re(CO)3(L6)(H2O)][NO3] | fac-[Re(CO)3(L6)(H2O)][NO3] (compound 6), the rhenium(I) tricarbonyl aqueous complex, is an anticancer agent associated with mitochondrial dysfunction. | |
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V34770 | Famitinib malate (SHR1020 malate) | 1256377-67-9 | Famitinib (SHR1020) malate is a potent, orally bioactive, multi-target kinase inhibitor that can suppress the activities of c-kit, VEGFR-2 and PDGFRβ with IC50s of 2.3 nM, 4.7 nM and 6.6 nM respectively. |
|
V31465 | FB23-2 | 2243736-45-8 | FB23-2 (FB23-2; FB-23-2; FB 232) is a novel, potent and selective inhibitor of mRNA N6-methyladenosine (m6A) demethylase FTO with potential anticancer activity. |
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