Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V34801 | Ganoderic acid R | 103963-39-9 | Ganoderic acid R is a potent anticancer agent. |
|
V34800 | Ganoderic acid S | 103963-38-8 | Ganoderic acid S is a positional isomer of Ganoderic acid, which can be extracted from the fermented mycelium of Ganoderma lucidum. |
|
V78021 | Ganoderic acid T1 | Ganoderic acid T1 is the deacetylated analogue of Ganoderic acid T. | |
|
V54824 | Ganoderic acid | 86377-53-9 | Ganoderic acid X is a lanosterol triterpenoid found in Ganoderma amboinense. |
|
V54846 | Garcinone E | 112649-21-5 | Garcinone E is a naturally occurring flavonoid found in the peel of mangosteen. |
|
V52067 | Garivulimab (BGB-A333) | 2342597-81-1 | Garivulimab (BGB-A333) is a humanized IgG1 variant monoclonal antibody (mAb) that specifically targets and binds to PD-L1. |
|
V85820 | GD3 Ganglioside | 62010-37-1 | |
|
V52065 | GDC-2394 | 2238822-07-4 | GDC-2394 is an orally bioactive and selective NLRP3 inhibitor that also inhibits IL-1β with IC50 of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). |
|
V52063 | Gemcitabine elaidate hydrochloride (CP-4126 hydrochloride; CO-101 hydrochloride; Gemcitabine 5'-elaidate hydrochloride) | 2918768-08-6 | Gemcitabine elaidate (CP-4126) HCl is the lipophilic precursor of Gemcitabine. |
|
V4888 | Gemcitabine monophosphate disodium | 1638288-31-9 | Gemcitabine monophosphate disodium (GemMP) is a monophosphate analog of Gemcitabine(formerly also known as LY-188011, NSC 613327; dFdC; dFdCyd; gemcitabine; trade name: Gemzar), anantimetabolite anticancer drug, which is a potent DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
|
V52720 | Gemcitabine-13C,15N2 hydrochloride (LY 188011-13C,15N2 hydrochloride) | 2757566-59-7 | Gemcitabine-13C,15N2 ( HCl) is 13C (carbon 13) and 15N (nitrogen 15) labelled Gemcitabine HCl. |
|
V2363 | Geniposidic acid | 27741-01-1 | Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders. |
|
V52613 | Genistein-d4 (NPI 031L-d4) | 187960-08-3 | Genistein-d4 is the deuterium labelled form of Genistein. |
|
V52061 | Germanicol | 465-02-1 | Germanicol is a selective anti-tumor agent that suppresses the growth of human colon cancer cell lines HCT-116 and HT29. |
|
V52060 | GGTI-2154 hydrochloride | 478908-50-8 | GGTI-2154 HCl is a potent and specific inhibitor of geranylgeranyltransferase I (GGTase I) with IC50 of 21 nM. |
|
V21574 | GGTI-2418 | 501010-06-6 | GGTI-2418 is a potent, competitive and selective geranylgeranyltransferase I (GGTase I) inhibitor. |
|
V53383 | Ginsenoside F5 (Ginsenoside F5) | 189513-26-6 | Ginsenoside F5, which can be found in Panax ginseng, significantly suppresses the growth of HL-60 cells through the apoptosis pathway. |
|
V84114 | Ginsenoside Rs3 | 194861-70-6 | |
|
V52059 | Girinimbine (Girinimbin) | 23095-44-5 | Girinimbine (Girinimbin) is a carbazole alkaloid with multiple biological effects. |
|
V52058 | GK563 | 2351820-19-2 | GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor (antagonist) with IC50 of 1 nM. |
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