Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54895 | GKK1032B | 358375-11-8 | GKK1032B is an alkaloid compound present in the endophytic fungus Penicillium spp. |
|
V52057 | GL0388 | 2886772-68-3 | GL0388 is a Bax activator that causes Bax to insert into the mitochondrial membrane. |
|
V79605 | GLP-2(rat) TFA | GLP-2(rat) TFA is an intestinal growth factor. | |
|
V52053 | Glychionide A (norwogonin-7-O-glucuronide) | 119152-50-0 | Glychionide A is a flavonoid glycoside found in the roots of Glychirriza glabra. |
|
V54282 | Glycoborinine | 233279-39-5 | Glycoborinine is a natural carbazole alkaloid extracted from Glycosmis pentaphylla. |
|
V52630 | Glycochenodeoxycholic acid-d4 (Chenodeoxycholylglycine-d4) | 1201918-16-2 | Glycochenodeoxycholic acid-d4 is the deuterated form of Glycochenodeoxycholic acid. |
|
V52051 | GN25 | 1227401-27-5 | GN25 is a specific p53-Snail binding inhibitor (antagonist) with anti-tumor effects. |
|
V55008 | Gnetifolin E | 140671-07-4 | Gnetifolin E is a resveratrol trimer analogue that can be extracted from Gnetum brunonianum<,i>. |
|
V29609 | Gomisin N | 69176-52-9 | Gomisin N is extracted from Schisandra chinensis and has good effects on promoting tranquility and sleep in animal models. |
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V52046 | GPX4-IN-3 | 2761004-85-5 | GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor that selectively induces ferroptosis. |
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V55024 | GPX4-IN-5 | 2922824-09-5 | GPX4-IN-5 (Compound C18) is a covalent inhibitor of GPX4 with IC50 of 0.12 μM. |
|
V56460 | GPX4-IN-6 | 2922824-07-3 | GPX4-IN-6 (Compound C25) is a covalent inhibitor of GPX4 with IC50 of 0.12 μM. |
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V21764 | Gracillin | 19083-00-2 | Gracillin is a steroidal saponin found in the roots of the plant that has anti-tumor properties. |
|
V2052 | Grape Seed Extract | 84929-27-1 | Grape Seed Extract is a natural product isolated from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs. |
|
V54855 | Griffipavisanthone ((+)-Griffavixanthone) | 219649-95-3 | Griffapavixanthone can be found in Garcinia schomburgkiana. |
|
V56335 | Griseofulvin-d3 (griseofulvin-d3) | 1279033-22-5 | Griseofulvin-d3 is the deuterium labelled form of Griseofulvin. |
|
V3602 | GSK4112 | 1216744-19-2 | GSK4112 is a novel and potent Rev-erbα agonist with EC50 of 0.4 μM in a biochemical assay measuring the interaction between Rev-erbα and a peptide from the nuclear receptor corepressor-1 (NCoR). |
|
V79666 | GSPT1 degrader-1 | GSPT1 degrader-1 (compound 9q) is a potent degrader of G1 to S phase transition 1 (GSPT1) via the ubiquitin-proteasome system. | |
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V52024 | GY1-22 | 326903-84-8 | GY1-22 is an inhibitor (blocker/antagonist) of DNAJA1-mutP53R175H interaction. |
|
V52023 | GZD856 formic | 2804039-78-7 | GZD856 formic is a potent and orally bioactive PDGFRα/β inhibitor (antagonist) with IC50s of 68.6 and 136.6 nM, respectively. |
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