Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54932 | HB3 | 1644272-97-8 | Hrk BH3 is a biologically active peptide. |
|
V2293 | HS-1793 | 927885-00-5 | HS-1793 is a Resveratrol analog with anti-tumor activity in a variety of cancer/tumor cells. |
|
V51964 | Humulone (α-Lupulic acid) | 26472-41-3 | Humulone (α-Lupulic acid) is a prenylated phloroglucinol analogue and a potent cyclooxygenase 2 (COX-2) inhibitor. |
|
V51963 | HX630 | 188844-52-2 | HX630 is a potent retinoic acid X receptor (RXR) agonist that can cause apoptosis and has anti-tumor effects and may be utilized in Cushing's disease study. |
|
V51962 | HXR9 | 917953-08-3 | HXR9 is a cell-permeable (penetrable) peptide and a competitive antagonist of HOX/PBX interaction. |
|
V54894 | Hydroxy-PP-Me | 833481-77-9 | Hydroxy-PP-Me is a potent and specific CBR1 inhibitor (antagonist) with IC50 of 759 nM. |
|
V34694 | Hypocretin (70-98), human | 1129545-33-0 | Hypocretin (70-98), human is a polypeptide that can bind to the orexin receptor OX1R and promote apoptosis. |
|
V12246 | Ibandronate sodium monohydrate | 138926-19-9 | Ibandronate sodium monohydrate (BM210955; RPR102289A) is abisphosphonate drug used for the treatment of osteoporosis, acting byincreasing bone mineral density, preventing resorption, and decreasing osteoclast activity. |
|
V52545 | Ibandronic acid-d3 | 1130899-41-0 | Ibandronic acid-d3 is the deuterated form of Ibandronic acid. |
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V56421 | Ibandronic Acid-d3 sodium | 1329834-28-7 | Ibandronic Acid-d3 (sodium) is the deuterated form of Ibandronic acid. |
|
V52649 | Ibuprofen-d3 sodium ((±)-Ibuprofen-d3 (sodium)) | 1219805-09-0 | Ibuprofen-d3 (sodium) is the deuterium labelled form of Ibuprofen sodium. |
|
V51955 | Icariside D2 | 38954-02-8 | Icariside D2 is extracted from Annona glabra and inhibits angiotensin-converting enzyme. |
|
V2249 | ICCB-280 | 2041072-41-5 | ICCB280 is a potent C/EBPα inducer. |
|
V54953 | IETD-CHO (Caspase-8-IN-1) | 886462-83-5 | IETD-CHO (Caspase-8-IN-1) is a potent caspase-8 inhibitor. |
|
V54804 | Ifabotuzumab (KB004) | 2147698-66-4 | Ifabotuzumab (KB004) is an IgG1κ antibody targeting EphA3 (KD=610 pM). |
|
V51952 | Illudin M | 1146-04-9 | Illudin M is a cytotoxic fungal sesquiterpene extracted from the culture medium of the Omphalotus illudens mushroom. |
|
V84642 | iMAC2 hydrochloride | 335166-00-2 | |
|
V54803 | Imifoplatin (PT-112) | 1339960-28-9 | Imifoplatin (PT-112) is a platinum-based reactive molecule that belongs to the phosphoplatin family. |
|
V52554 | Imipramine-d4 hydrochloride (imipramine d4 hydrochloride) | 61361-33-9 | Imipramine-d4 ( HCl) is the deuterated form of Imipramine HCl. |
|
V34776 | Immuno modulator-1 | 2757469-20-6 | Immuno modulator-1 (compound 22) inhibits the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC) with IC50s of 4.7 and 26 nM, respectively. |
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