Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V80729 | Me4Phen | Me4Phen (compound 3) is an oxygen rhenium (V) complex that can deplete mitochondrial membrane potential and upregulate intracellular reactive oxygen species (ROS), leading to endoplasmic reticulum stress-mediated necrosis of cancer cells. | |
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V54900 | Mechercharmycin A | 822520-96-7 | Mechercharmycin A is a cytotoxic substance extracted from Thermoactinomyces sp. |
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V51798 | Meclizine dihydrochloride monohydrate (Meclizine dihydrochloride monohydrate; Meclizine dihydrochloride monohydrate) | 31884-77-2 | Meclizine (Meclozine) di-HCl monohydrate is an antihistamine that reversibly inhibits the interaction of histamine with H1 receptors. |
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V54843 | Meclizine-d8 (Meclozine-d8) | 1246816-06-7 | Meclizine-d8 is a deuterated marker of Meclizine. |
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V56409 | Meclizine-d8 dihydrochloride (Meclozine-d8(dihydrochloride)) | 1432062-16-2 | Meclizine-d8 (di-HCl) is the deuterated form of Meclizine di-HCl. |
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V19104 | Medicarpin | 32383-76-9 | Medicarpin isa naturally occuring flavonoidextracted from the herb of Hedysarum polybotrys Hand. |
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V23689 | Meisoindigo | 97207-47-1 | Meisoindigo (Dian III) is an analogue of Indirubin, which can cause acute myeloid leukemia (AML) cell cycle arrest in the G0/G1 phase and cause apoptosis. |
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V52779 | Melatonin-d3 (N-Acetyl-5-methoxytryptamine-d3) | 90735-69-6 | Melatonin-d3 is the deuterated form of Melatonin. |
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V56393 | Melatonin-d7 (N-Acetyl-5-methoxytryptamine-d7) | 615251-68-8 | Melatonin-d7 is the deuterated form of Melatonin. |
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V51685 | Melflufen hydrochloride (Melphalan flufenamide hydrochloride) | 380449-54-7 | Melflufen (Melphalan flufenamide) HCl, a dipeptide precursor active molecule of Melphalan, is an alkylating agent. |
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V35039 | Melittin free acid | 123168-46-7 | Melittin free acid is a basic peptide consisting of 26 amino acid (AA)s and is the main active component of bee venom. |
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V56431 | Meloxicam-d3-1 (meloxicam d3-1) | 1227358-55-5 | Meloxicam-d3-1 is the deuterium labelled form of Meloxicam. |
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V54979 | MeOIstPyrd | 2308548-54-9 | MeOIstPyrd is a skin cancer-fighting compound. |
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V51371 | Mepazine hydrochloride (Pecazine hydrochloride) | 2975-36-2 | Mepazine HCl (Pecazine HCl) is a potent and specific MALT1 protease inhibitor. |
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V52618 | Methotrexate-d3 (methotrexate d3) | 432545-63-6 | Methotrexate-d3 is the deuterated form of Methotrexate. |
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V54917 | Methyl 12-methyltridecanoate | 5129-58-8 | Methyl 12-methyltridecanoate ((R)-betaxolol HCl) is a biosurfactant found in Brevibacterium casei LS14. |
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V56416 | Methyl 3,4-dihydroxybenzoate-d3-1 | 2733147-54-9 | Methyl 3,4-dihydroxybenzoate-d3-1 is the deuterated form of Methyl 3,4-dihydroxybenzoate. |
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V52598 | Metoprolol-d5 (Metoprolol-d5) | 959786-79-9 | Metoprolol-d5 is the deuterium labelled form of Metoprolol. |
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V56301 | Metronidazole-13C2,15N2 (Metronidazole 13C2,15N2) | 1173020-03-5 | Metronidazole-13C2,15N2 is a 13C (carbon 13) and 15N (nitrogen 15) labelled Metronidazole. |
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V56307 | Metronidazole-d4 (Metronidazole d4) | 1261392-47-5 | Metronidazole-d4 is the deuterium labelled form of Metronidazole. |
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