Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V53507 | Nargenicin A1 | 70695-02-2 | Nargenicin A1 is an antibiotic against a variety of Gram-positive (Gram+) bacteria. |
|
V41134 | Nauclefine | 57103-51-2 | Nauclefine is an indole alkaloid extracted from Nauclea officinalis. |
|
V56439 | Navitoclax-d8 (rooting powder 263 d8) | 1217620-38-6 | Navitoclax-d8 is the deuterium labelled form of Navitoclax. |
|
V41132 | NCT-58 | 2411429-33-7 | NCT-58 is a potent inhibitor of the C-terminus of HSP90. |
|
V54986 | Nec-3a | 1504558-72-8 | Nec-3a is a Necrostatin-3 analogue. |
|
V52896 | Necroptosis-IN-1 | 1391980-92-9 | Necroptosis-IN-1 is an analog of Necrostatin-1, an inhibitor (blocker/antagonist) of necroptosis, and an inhibitor (blocker/antagonist) of RIPK. |
|
V85495 | Necrosis inhibitor 3 | 2258670-86-7 | |
|
V41127 | Necrostatin-34 | 375835-43-1 | Necrostatin-34 (Nec-34) is an inhibitor (blocker/antagonist) of RIPK1 kinase that stabilizes RIPK1 in an inactive state by occupying a specific binding pocket in the kinase domain. |
|
V41125 | Necrostatin-5 (Nec-5) | 337349-54-9 | Necrostatin-5 (Nec-5) is a potent inhibitor of necroptosis with EC50 of 0.24 µM. |
|
V41124 | Neihulizumab (ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab)) | 2158362-38-8 | Neihulizumab (ALTB-168) is an immune checkpoint agonist antibody that binds to human CD162 (PSGL-1), resulting in downregulation of activated T cells. |
|
V52596 | Nelfinavir-d3 | 1217629-70-3 | Nelfinavir-d3 is the deuterium labelled form of Nelfinavir. |
|
V41123 | Nemorosone | 351416-47-2 | Nemorosone is the major component of Clusia rosea resin. |
|
V56388 | Neochamaejasmine A | 90411-13-5 | Neochamaejasmine A is a biflavonoid that can be extracted from the roots of Stellera chamaejasme L. Neochamaejasmine A inhibits tumor cell proliferation/growth and induces tumor cell cycle arrest and apoptosis. |
|
V41117 | Neoechinulin A | 51551-29-2 | Neoechinulin A is a prenyl indole alkaloid with scavenging, neurotrophic factor-like, and antiapoptotic activities. |
|
V34687 | Neoxanthin (neoxanthin) | 14660-91-4 | Neoxanthin is a major xanthophyll carotenoid found in dark green leafy vegetables and is a precursor to the plant hormone abscisic acid. |
|
V55016 | Nerelimomab (BAYX1351) | 162774-06-3 | Nerelimomab (BAYX1351) is an anti-TNF-α antibody. |
|
V41114 | Neriifolin (Neriifolin; 17β-Neriifolin) | 466-07-9 | Neriifolin is a cardiac glycoside that penetrates the central nervous system/CNS and is an inhibitor (blocker/antagonist) of Na+, K+-ATPase. |
|
V41110 | NHWD-870 | 2115742-03-3 | NHWD-870 is a potent, orally bioactive and selective BET family bromodomain inhibitor that binds only to BRD2, BRD3, BRD4 (IC50=2.7 nM) and BRDT. |
|
V41108 | Nimustine | 42471-28-3 | Nimustine is a nitrosourea alkylating agent. |
|
V18997 | Nirogacestat dihydrobromide (PF-3084014 dihydrobromide; PF-03084014 dihydrobromide) | 1962925-29-6 | Nirogacestat diHBr (PF-3084014 diHBr) is a potent, orally bioactive, reversible, noncompetitive and selective γ-secretase inhibitor (antagonist) with IC50 of 6.2 nM. |
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