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Apoptosis

Apoptosis

Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.

There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.

Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.

Apoptosis related products

Structure Cat No. Product Name CAS No. Product Description
ABL-L V54884 ABL-L 1613152-39-8 ABL-L causes apoptosis in human laryngeal cancer/tumor cells through a p53-dependent pathway.
ABT-510 TFA salts V9987 ABT-510 TFA salts 251579-55-2 ABT-510 TFA, the trifluoroacetic acid (TFA) salt form of ABT-510 which is a TSP-1 mimetic drug,is a synthetic peptide composed of nine-amino acids, it acts bymimicking the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1).
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) V54963 Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) 201608-15-3 Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible caspase-3 inhibitor.
Ac-AAVALLPAVLLALLAP-LEHD-CHO V54951 Ac-AAVALLPAVLLALLAP-LEHD-CHO 623948-42-5 Ac-AAVALLPAVLLALLAP-LEHD-CHO is an inhibitor (blocker/antagonist) of caspases 4, 5 and 9.
Ac-DEVD-CMK (Caspase-3 Inhibitor III) V52454 Ac-DEVD-CMK (Caspase-3 Inhibitor III) 285570-60-7 Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor.
Ac-DMQD-AMC V85923 Ac-DMQD-AMC 355137-38-1
Ac-Ile-Glu-Thr-Asp-pNA V54948 Ac-Ile-Glu-Thr-Asp-pNA 219138-21-3 Ac-Ile-Glu-Thr-Asp-pNA is a substrate of caspase-8.
Ac-LDESD-AMC V85928 Ac-LDESD-AMC
Ac-LEHD-AMC V54962 Ac-LEHD-AMC 292633-16-0 Ac-LEHD-AMC is a fluorescent substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm).
Ac-LETD-CHO V85689 Ac-LETD-CHO
Ac-LEVD-CHO V85929 Ac-LEVD-CHO 402832-01-3
Ac-Trp-Glu-His-Asp-Aldehyde V56290 Ac-Trp-Glu-His-Asp-Aldehyde 189275-71-6 Ac-Trp-Glu-His-Asp-Aldehyde is a potent and specific caspase-1 inhibitor (antagonist) with Ki of 56 pM.
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) V54949 Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) 189275-74-9 Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is an efficient fluorescent substrate for caspase-1.
Ac-Tyr-Val-Lys-Asp-aldehyde V54955 Ac-Tyr-Val-Lys-Asp-aldehyde 147821-01-0 Ac-Tyr-Val-Lys-Asp-aldehyde is a caspase-1 inhibitor and can be used for disease study on chronic disease-related anemia, chemotherapy-induced anemia and diamond-black fan anemia.
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) V54965 Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) 147837-52-3 Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor.
Ac-VRPR-AMC V54956 Ac-VRPR-AMC 919515-51-8 Ac-VRPR-AMC is a fluorescent metacaspase substrate.
Ac-YVAD-AOM V54966 Ac-YVAD-AOM 154674-81-4 Ac-YVAD-AOM is an inhibitor (blocker/antagonist) of caspase-1 and has anti-tumor activity.
Ac-YVAD-pNA V53397 Ac-YVAD-pNA 149231-66-3 Ac-YVAD-pNA is a specific caspase-1 substrate.
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) V10036 Acacetin (5,7-Dihydroxy-4'-methoxyflavone) 480-44-4 Derived fromDendranthema morifolium, Acacetin is a novel and potent Flavonoid.
Acyclovir-d4 (Aciclovir-d4; Acycloguanosine-d4) V56218 Acyclovir-d4 (Aciclovir-d4; Acycloguanosine-d4) 1185179-33-2 Acyclovir-d4 is the deuterium labelled form of Acyclovir.
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