Apoptosis

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Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
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Apoptosis

Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.

There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.

Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.

Apoptosis related products

Cat No.	Product Name	CAS No.	Product Description
V54971	Anticancer agent 128	2941243-62-3	Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domain of XIAP, cIAP1, and cIAP2.
V77982	Anticancer agent 130		anti-cancer compound 130 (compound 8d) is an anti-cancer compound that can significantly cause apoptosis in A549 cells.
V77983	Anticancer agent 134		Anticancer agent 134 (compound 6a) is an environmentally sensitive fluorescent probe and apoptosis inducer that can differentiate between tumors and normal tissues.
V77984	Anticancer agent 136		Anticancer agent 136 (compound 22) is a C17-triazole analog of geldanamycin (GDM) with IC50 of 3.38 μM for HDF and a Kd of 3.86 μM for Hsp90.
V54899	Anticancer agent 14	2762698-14-4	Anticancer agent 14 is a lead compound (IC50= 0.20 to 0.65 μM) that causes apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.
V56457	Anticancer agent 147	2241283-11-2	Anticancer agent 147 (compound 6j) is an analogue of sophoridine and is a ferroptosis inducer.
V77987	Anticancer agent 153		Anticancer agent 153 (Compound 3) causes apoptosis by inducing the generation of reactive oxygen species (Reactive Oxygen Species).
V52237	Anticancer agent 164	2235393-30-1	CML-IN-1 (compound 7) is a potent anticancer agent.
V85396	Anticancer agent 178
V85439	Anticancer agent 183	3018960-58-9
V84935	Anticancer agent 184
V34996	Anticancer agent 84	2714510-72-0	Anticancer agent 84 is an anticancer agent.
V34995	Anticancer agent 99	2914922-83-9	Anticancer agent 99 (compound 2p) has good anti-cancer activity against HepG2 cells, with IC50 of 35.9 μM.
V78494	Antimycin A2c		Anticancer agent 141 (compound AE) is an antimycin alkaloid with inhibitory potential against HPV-infected cervical cancer.
V78743	Antiproliferative agent-19		antiproliferation agent-19 (compound 4a) is an anticancer agent that exerts antiproliferation effects on lung cancer cells by inducing apoptosis.
V78645	Antiproliferative agent-27		antiproliferation agent-27 (compound 11) is an antiproliferation agent that can significantly reduce the number of tumor cell colonies and cause apoptosis.
V54885	Antiproliferative agent-32	2925814-05-5	antiproliferation agent-32 (Compound 1c) inhibits the phosphorylation of the PI3K/Akt/mTOR signaling pathway.
V78057	Antiproliferative agent-43		antiproliferation agent-43 (Compound e4) has a significant cytotoxic effect on tumor cells, causing cell apoptosis by stopping the cell cycle in the G1 phase.
V54839	Antitumor agent-100	2841750-32-9	Antitumor agent-100 (compound A6) is an inducer of apoptosis and a molecular glue with superior anti-tumor activity.
V54883	Antitumor agent-100 hydrochloride	2841750-53-4	Antitumor agent-100 HCl (compound A6) is an inducer of apoptosis and a molecular glue with superior anti-tumor activity.