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Apoptosis

Apoptosis

Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.

There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.

Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.

Apoptosis related products

Structure Cat No. Product Name CAS No. Product Description
Anticancer agent 104 V77924 Anticancer agent 104 anti-cancer compound 104 has anti-cancer effect and causes apoptosis in cancer/tumor cells.
Anticancer agent 105 V35001 Anticancer agent 105 2450987-57-0 Anticancer agent 105 is a thienopyrimidine scaffold-based compound with good safety and anticancer properties.
Anticancer agent 106 V78810 Anticancer agent 106 Anticancer agent 106 (compound 10ic) is an anticancer agent that causes apoptosis in B16-F10 melanoma cells.
Anticancer agent 110 V35000 Anticancer agent 110 887349-03-3 Anticancer agent 110 is an anticancer agent with in vitro anti-cancer activity as well as excellent antileukemic potency.
Anticancer agent 118 V34999 Anticancer agent 118 864443-43-6 Anticancer agent 118 is an N-acylated ciprofloxacin analogue with antibacterial and anticancer activities.
Anticancer agent 119 V54851 Anticancer agent 119 2928614-16-6 Anticancer agent 119 (compound 15) is an N-acylated ciprofloxacin analogue that has certain anti-bacterial effect and can induce the production of ROS to induce apoptosis of cancer cells.
Anticancer agent 120 V53845 Anticancer agent 120 2928614-22-4 Anticancer agent 120 (compound 21) is an N-acylated ciprofloxacin analogue that has certain anti-bacterial effect and can induce the production of ROS to induce apoptosis of cancer cells.
Anticancer agent 128 V54971 Anticancer agent 128 2941243-62-3 Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domain of XIAP, cIAP1, and cIAP2.
Anticancer agent 130 V77982 Anticancer agent 130 anti-cancer compound 130 (compound 8d) is an anti-cancer compound that can significantly cause apoptosis in A549 cells.
Anticancer agent 134 V77983 Anticancer agent 134 Anticancer agent 134 (compound 6a) is an environmentally sensitive fluorescent probe and apoptosis inducer that can differentiate between tumors and normal tissues.
Anticancer agent 136 V77984 Anticancer agent 136 Anticancer agent 136 (compound 22) is a C17-triazole analog of geldanamycin (GDM) with IC50 of 3.38 μM for HDF and a Kd of 3.86 μM for Hsp90.
Anticancer agent 14 V54899 Anticancer agent 14 2762698-14-4 Anticancer agent 14 is a lead compound (IC50= 0.20 to 0.65 μM) that causes apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.
Anticancer agent 147 V56457 Anticancer agent 147 2241283-11-2 Anticancer agent 147 (compound 6j) is an analogue of sophoridine and is a ferroptosis inducer.
Anticancer agent 153 V77987 Anticancer agent 153 Anticancer agent 153 (Compound 3) causes apoptosis by inducing the generation of reactive oxygen species (Reactive Oxygen Species).
Anticancer agent 164 V52237 Anticancer agent 164 2235393-30-1 CML-IN-1 (compound 7) is a potent anticancer agent.
Anticancer agent 178 V85396 Anticancer agent 178
Anticancer agent 183 V85439 Anticancer agent 183 3018960-58-9
Anticancer agent 184 V84935 Anticancer agent 184
Anticancer agent 84 V34996 Anticancer agent 84 2714510-72-0 Anticancer agent 84 is an anticancer agent.
Anticancer agent 99 V34995 Anticancer agent 99 2914922-83-9 Anticancer agent 99 (compound 2p) has good anti-cancer activity against HepG2 cells, with IC50 of 35.9 μM.
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