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Apoptosis

Apoptosis

Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.

There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.

Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.

Apoptosis related products

Structure Cat No. Product Name CAS No. Product Description
Antimycin A2c V78494 Antimycin A2c Anticancer agent 141 (compound AE) is an antimycin alkaloid with inhibitory potential against HPV-infected cervical cancer.
Antiproliferative agent-19 V78743 Antiproliferative agent-19 antiproliferation agent-19 (compound 4a) is an anticancer agent that exerts antiproliferation effects on lung cancer cells by inducing apoptosis.
Antiproliferative agent-27 V78645 Antiproliferative agent-27 antiproliferation agent-27 (compound 11) is an antiproliferation agent that can significantly reduce the number of tumor cell colonies and cause apoptosis.
Antiproliferative agent-32 V54885 Antiproliferative agent-32 2925814-05-5 antiproliferation agent-32 (Compound 1c) inhibits the phosphorylation of the PI3K/Akt/mTOR signaling pathway.
Antiproliferative agent-43 V78057 Antiproliferative agent-43 antiproliferation agent-43 (Compound e4) has a significant cytotoxic effect on tumor cells, causing cell apoptosis by stopping the cell cycle in the G1 phase.
Antitumor agent-100 V54839 Antitumor agent-100 2841750-32-9 Antitumor agent-100 (compound A6) is an inducer of apoptosis and a molecular glue with superior anti-tumor activity.
Antitumor agent-100 hydrochloride V54883 Antitumor agent-100 hydrochloride 2841750-53-4 Antitumor agent-100 HCl (compound A6) is an inducer of apoptosis and a molecular glue with superior anti-tumor activity.
Antitumor agent-103 V78071 Antitumor agent-103 Antitumor agent-103 (compound 24l) is an apoptosis inducer with antiproliferation and anti-clonogenic activities.
Antitumor agent-110 V54870 Antitumor agent-110 2563879-93-4 Antitumor agent-110 (compound 13) is an anticancer imidazotetrazine with good penetrability.
Antitumor agent-112 V80017 Antitumor agent-112 Antitumor agent-112 (compound 3a) is a potent antitumor agent.
Antitumor agent-113 V78073 Antitumor agent-113 Antitumor agent-113 has a cytotoxic effect on A549 cells, with IC50 of 46.60 μM, and can cause apoptosis.
Antitumor agent-115 V34820 Antitumor agent-115 2759277-20-6 Antitumor agent-115 (SS-12) is a potent in vitro antitumor compound with IC50 of 0.34 μM-24.14 μM against mouse breast cancer cell line 4T1 cells.
Antitumor agent-126 V85862 Antitumor agent-126 3014356-10-3
Antitumor agent-128 V85045 Antitumor agent-128 1942910-49-7
Antitumor agent-135 V84410 Antitumor agent-135
Antitumor agent-36 V78077 Antitumor agent-36 Antitumor agent-36 has potent antiproliferation and antimetastatic activities.
Antitumor agent-37 V78078 Antitumor agent-37 Antitumor agent-37 has potent antiproliferation and antimetastatic activities.
Antitumor agent-76 V34815 Antitumor agent-76 2787593-12-6 Antitumor agent-76 (Compound TP-P1) is an orally bioactive, fast-release, water-soluble (H2O-soluble) Triptolide precursor with anti-cancer effect.
Antitumor agent-79 V52409 Antitumor agent-79 2750233-50-0 Antitumor agent-7 has good antiproliferation activity against hepatocellular carcinoma and breast cancer cells, with IC50 of 0.7-7.9 μM.
Antitumor agent-80 V34819 Antitumor agent-80 2758520-84-0 Antitumor agent-80 (compound 11) is an orally bioactive antitumor agent.
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