Apoptosis

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Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
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Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

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Apoptosis

Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.

There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.

Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.

Apoptosis related products

Cat No.	Product Name	CAS No.	Product Description
V78071	Antitumor agent-103		Antitumor agent-103 (compound 24l) is an apoptosis inducer with antiproliferation and anti-clonogenic activities.
V54870	Antitumor agent-110	2563879-93-4	Antitumor agent-110 (compound 13) is an anticancer imidazotetrazine with good penetrability.
V80017	Antitumor agent-112		Antitumor agent-112 (compound 3a) is a potent antitumor agent.
V78073	Antitumor agent-113		Antitumor agent-113 has a cytotoxic effect on A549 cells, with IC50 of 46.60 μM, and can cause apoptosis.
V34820	Antitumor agent-115	2759277-20-6	Antitumor agent-115 (SS-12) is a potent in vitro antitumor compound with IC50 of 0.34 μM-24.14 μM against mouse breast cancer cell line 4T1 cells.
V85862	Antitumor agent-126	3014356-10-3
V85045	Antitumor agent-128	1942910-49-7
V84410	Antitumor agent-135
V78077	Antitumor agent-36	3005986-81-9	Antitumor agent-36 has potent antiproliferation and antimetastatic activities.
V78078	Antitumor agent-37		Antitumor agent-37 has potent antiproliferation and antimetastatic activities.
V34815	Antitumor agent-76	2787593-12-6	Antitumor agent-76 (Compound TP-P1) is an orally bioactive, fast-release, water-soluble (H2O-soluble) Triptolide precursor with anti-cancer effect.
V52409	Antitumor agent-79	2750233-50-0	Antitumor agent-7 has good antiproliferation activity against hepatocellular carcinoma and breast cancer cells, with IC50 of 0.7-7.9 μM.
V34819	Antitumor agent-80	2758520-84-0	Antitumor agent-80 (compound 11) is an orally bioactive antitumor agent.
V78475	Antitumor agent-83		Antitumor agent-83 is an activator of the pro-apoptotic protein BAX and has a significant antiproliferation effect on tumor cells.
V34818	Antitumor agent-92	2922842-01-9	Antitumor agent-92 is an icariin analogue that can cause cell cycle arrest in the G0/G1 phase and cause apoptosis.
V78565	Antitumor agent-96	3041063-90-2	Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor.
V34817	Antitumor agent-97	2654024-16-3	Antitumor agent-97 (compound 42) is an anticancer agent.
V78081	Antitumor photosensitizer-4		Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2.
V52406	AP-III-a4 hydrochloride (ENOblock hydrochloride)	2070014-95-6	AP-III-a4 (ENOblock) HCl is a non-substrate analog enolase inhibitor (antagonist) with IC50 of 0.576 uM.
V52408	APE1-IN-2	2923433-95-6	APE1-IN-2 (compound AP1) is a Pt(IV) precursor that targets a key BER protein, apurinic/apyrimidine endonuclease 1 (APE1).