The pathogenesis of a wide range of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases, has been linked to tumor necrosis factor (TNF), a key mediator of apoptosis as well as inflammation and immunity.
TNF- α is a homotrimer in solution and a 17-kDa protein with 157 amino acids. The gene is located on chromosome 6 in humans. Its soluble TNF-binding receptors play a major role in controlling its bioactivity. T lymphocytes, natural killer cells, and activated macrophages are the main producers of TNF-α. Numerous other cells, such as fibroblasts, smooth muscle cells, and tumor cells, are known to have lower expression. TNF- is produced in cells as pro-TNF (26 kDa), which is membrane-bound and is released after TNF-converting enzyme (TACE) cleaves its pro domain.
The two TNF receptors, TNF-R1 and TNF-R2, which are both members of the TNF receptor super-family, mediate many of the cellular responses brought on by TNF. Most cell types respond to TNF treatment by activating the transcription factor NF-B and MAP kinases like ERK, p38, and JNK. In some cases, apoptosis or necrosis may also be induced. However, TNFR1, also referred to as a death receptor, is primarily responsible for the induction of apoptosis or necrosis. Numerous cytokines and immune-regulatory proteins are induced as a result of NF-B and MAPK activation, which is crucial for many inflammatory responses.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V79908 | NLRP3-IN-24 | NLRP3-IN-24 (compound 15a) is an inhibitor (blocker/antagonist) of NLRP3. | |
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V105456 | NSC 15830 hydrochloride | 2508026-62-6 | NSC 15830 (S-(1,2-dichlorovinyl)-L-cysteine) hydrochloride is a nephrotoxin and a metabolite of trichloroethylene. |
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V106440 | Nuvustotug | Nuvustotug is a human IgG1κ antibody directed against TNFRSF4. | |
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V88549 | ODN 1585 sodium | ODN 1585 sodium is a potent inducer of IFN and TNFα production. | |
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V88551 | PDE4-IN-15 | PDE4-IN-15 (compound 7b-1) is an inhibitor of PDE4 (IC50 = 0.17 μM) with anti-TNF-α activity (EC50 = 0.19 μM). | |
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V106296 | PIYLGGVFQ | PIYLGGVFQ is a peptide inhibitor of TNF-α. | |
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V106405 | Podentamig | Podentamig is a VH-VH'-(scFv-heavy-λ) chimeric antibody against CD3E/TNFRSF17. | |
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V105302 | PQA-18 | 1604678-82-1 | PQA-18 is a unique PAK2 inhibitor (IC50: 10 nM). |
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V106042 | rel-Cleroindicin F | 94535-01-0 | rel-Cleroindicin F (Rengyolone) is a cyclohexylacetyl compound isolated from the fruit of Forsythia suspensa with anti-inflammatory activity. |
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V104508 | Resolvin D2 n-3 DPA | 2093111-29-4 | Resolvin D2 n-3 DPA is a specialized protease mediator (SPM). |
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V105084 | sEH inhibitor-19 | sEH inhibitor-19 (compound (R)-14i) is an orally available soluble epoxide hydrolase (sEH) inhibitor with IC50 of 1.2 nM. | |
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V106445 | Solabafusp alfa | Solabafusp alfa is a humanized IgG4κ antibody directed against CD274/TNFRSF9. | |
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V89477 | Spirohypertone B | Spirohypertone B is a potent inhibitor of tumor necrosis factor-α (TNF-α). | |
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V106255 | TAT-N24 | TAT-N24 is a cell-permeable TAT peptide that acts as an inhibitor of p55PIK signaling. | |
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V81596 | TNF-alpha-IN-1 | TNF-alpha-IN-1 (compound 202) is an orally bioactive TNF-alpha inhibitor. | |
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V76405 | TNF-α (31-45), human TFA | TNF-α (31-45), human TFA is a polypeptide fragment of human tumor necrosis factor-α. | |
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V76404 | TNF-α (46-65), human TFA | TNF-α (46-65), human (TFA) is a polypeptide fragment of human TNF-α. | |
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V79140 | TNF-α-IN-11 | 2945197-77-1 | TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor (antagonist) with a Kd of 12.06 μM. |
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V84597 | TNF-α-IN-12 | 364039-56-5 | |
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V84582 | TNF-α-IN-13 | 364039-48-5 |
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