The complement system, which is made up of more than 30 serum and cell surface components, works with the innate and acquired immune systems to recognize and get rid of pathogens. Following the activation of the complement system, a series of events involving proteolysis and assembly lead to the cleavage of the third complement component (C3). The activation pathway refers to the cascade that leads to C3 cleavage. The classical, lectin, and alternative pathways are the three types of activation.
The complement cascade is a double-edged sword that causes phagocytosis and inflammation while also providing defense against viral and bacterial invasion. If complement is not properly controlled, it can cause significant pathological damage to erythrocytes (hemolysis), kidney basement membrane and attached endothelial and epithelial cells (nephritis), joint synovium (arthritis), and blood vessels (vasculitis).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78850 | Complement C1s-IN-1 | Complement C1s-IN-1 is a specific, orally bioactive C1s inhibitor that crosses the BBB (blood-brain barrier) with IC50 of 36 nM. | |
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V3627 | Complement factor D-IN-2 | 1903742-34-6 | Complement factor D-IN-2 (extracted fromWO2015130838A1, compound 190) is an inhibitor of complement factor D with the potential to be used for treating autoimmune diseases. |
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V77143 | Compstatin TFA | Compstatin TFA is a 13-residue cyclic peptide that is a potent inhibitor of complement system C3 and is species-specific. | |
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V86832 | CP-289,503 | 1349637-14-4 | CP-289,503 is an inhibitor of complement C5a receptor with an IC50 of 1 μM. |
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V12980 | CP-447697 | 1092847-21-6 | CP-447697 is a lipophilic C5a receptor blocker (antagonist) with IC50 of 31 nM. |
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V56305 | Cyclosporin A-d3 (Cyclosporin A-d3; Ciclosporin A-d3; CsA-d3) | 222295-76-3 | Cyclosporin A-d3 is a stable isotope d3-labeled Cyclosporin A . |
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V32062 | Danicopan (ACH-4471) | 1903768-17-1 | Danicopan(ACH4471) is a novel, selective and orally bioavailable small-molecule factor D inhibitor, which inhibits alternative pathway of complement (APC) activity. |
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V33581 | EG00229 TFA | 1210945-69-9 | EG-00229 TFA, the trifluoroacetic acid form of EG00229, is a novel and potent Neuropilin 1 (NRP1) receptor antagonist with antitumor effects. |
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V74776 | EG01377 dihydrochloride | 2749438-61-5 | EG01377 di-HCl is a potent, bioavailable and selective neuropilin-1 (NRP1) inhibitor (antagonist) with a Kd of 1.32 μM and IC50 of 609 nM for both NRP1-a1 and NRP1-b1. |
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V74786 | Factor B-IN-1 | 1481631-75-7 | Factor B-IN-1 is a Factor B inhibitor. |
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V74785 | Factor D inhibitor 6 | 1386455-51-1 | Factor D inhibitor 6 is a specific, orally bioactive factor D (factor D) inhibitor (antagonist) with IC50 of 30 nM and a Kd of 6 nM. |
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V74788 | IONIS-FB-LRx (RG6299) | 2272975-74-1 | IONIS-FB-LRx is a specialized antisense oligonucleotide (ASO) targeting complement factor B (CFB). |
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V80391 | IONIS-FB-LRx sodium (RG6299 sodium) | IONIS-FB-LRx sodium is a specialized antisense oligonucleotide (ASO) targeting complement factor B (CFB). | |
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V51028 | JPE-1375 | 1254036-23-1 | JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. |
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V74796 | L-156602 (Antibiotic L 156602; PD 124966) | 125228-51-5 | L-156602 is a C5a receptor antagonist. |
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V74782 | Lipoteichoic acid | 56411-57-5 | Lipoteichoic acid is a component of the cell wall of Staphylococcus aureus and activates the complement system by inducing C3 and inhibiting CD55. |
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V76703 | NH2-C6-ARC186 sodium | NH2-C6-ARC186 sodium is an ARC186 with an NH2-C6 linker that can be coupled to other peptides or molecules. | |
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V99857 | Pegcetacoplan acetate | Pegcetacoplan acetate is a pegylated complement C3 inhibitory peptide. | |
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V106276 | PIC1 PA | 1356469-36-7 | PIC1 PA, a 15-amino acid peptide, is a potent PIC1 analog that inhibits complement activation mediated by the classical pathway. |
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V76618 | PMX 205 Trifluoroacetate | PMX 205 Trifluoroacetate is a potent complement C5a receptor (C5aR; CD88) antagonist. |
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