A group of enzymes known as nitric oxide synthases (NOSs) are responsible for producing nitric oxide (NO) from L-arginine. L-arginine is oxidized to produce NO and L-citrulline by NO synthases. Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) are the three NOS isoforms found in mammals. Numerous physiological processes in the nervous, immune, and cardiovascular systems involve NO produced by these various NOS isoforms. Pathologic conditions such as stroke, inflammation, and hypertension can result from uncontrolled NO production. As a result, isoform-specific NOS inhibitors have a lot of potential as therapeutic treatments for diseases linked to NO.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75093 | DETA NONOate (Diethylamine NONOate; NOC-18) | 146724-94-9 | DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. |
|
V75124 | Dimeric coniferyl acetate | 184046-40-0 | Dimeric coniferylacetate is an inhibitor (blocker/antagonist) of NO production with IC50 of 7.9 μM in BV-2 microglia. |
|
V14325 | Dimethoxycurcumin | 160096-59-3 | Dimethoxycurcumin is a synthetic and metabolically more stable urcumin analogue with anti-inflammatory and antioxidant activities, inducing epigenetic changes in leukemia cells and the expression of promoter methylated genes. |
|
V85332 | Diplacol | 76556-05-3 | |
|
V75108 | GW274150 dihydrochloride | 438542-17-7 | GW274150 (di-HCl) is a specific, orally bioactive NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (Kd=40 nM) and rat (iNOS). |
|
V75136 | hnNOS-IN-2 | 2700326-00-5 | hnNOS-IN-2 (compound 17) is a human neuronal nitric oxide synthase (hnNOS) inhibitor (antagonist) with good metabolic stability. |
|
V75132 | hnNOS-IN-3 | 163490-78-6 | hnNOS-IN-3 (compound 39) is a selective nNOS inhibitor (antagonist) with Ki of 0.32 μM. |
|
V75140 | Inflexuside A | 1395048-85-7 | Inflexuside A is a firnane diterpene that can be extracted from the aerial parts of Cnidium monnieri. |
|
V75107 | Inflexuside B | 1395048-86-8 | Inflexuside B is a firnane diterpene that can be extracted from the aerial parts of Cnidium monnieri. |
|
V75104 | iNOS inhibitor-10 | 2918773-63-2 | iNOS inhibitor-10 (Compound 1b) is an iNOS inhibitor (IC50= 65 nM). |
|
V84029 | Isoarundinin I | 151538-57-7 | |
|
V75145 | Isolupalbigenin | 162616-70-8 | Isolupalbigenin is an inhibitor (blocker/antagonist) of NO. |
|
V75117 | Isomaculosidine | 518-96-7 | Isomaculosidine is an alkaloid extracted from D. |
|
V75151 | Isophysalin A | 1363398-67-7 | Isophysalin A is a physalis protein with an α,β-unsaturated ketone moiety. |
|
V80410 | Isosorbide dinitrate-13C6 (ISDN-13C6) | Isosorbide dinitrate-13C6 is 13C (carbon 13) labelled Isosorbide dinitrate. | |
|
V75141 | Juncutol | 1021950-14-0 | Juncutol is a potent inhibitor of inducible nitric oxide synthase (iNOS). |
|
V75134 | Kadsulignan H | 144049-91-2 | Kadsulignan H (compound 13) is a lignan with inhibitory activity on NO production. |
|
V31539 | L-Canavanine sulfate | 2219-31-0 | L-Canavanine sulfate is a selective inhibitor of inducible NO synthase (NO synthase). |
|
V30236 | L-NIL | 53774-63-3 | L-NIL is a selective inhibitor ofinducible nitric oxide synthase (iNOS) (IC50 = 3.3 μM for miNOS) with anti-inflammatory activity. |
|
V75148 | Lethedoside A | 221289-20-9 | Lethedoside A is a naturally occurring flavonoid compound that has inhibitory activity against LPS-induced NO production in RAW 264.7 cells. |
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