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NO Synthase

NO Synthase

A group of enzymes known as nitric oxide synthases (NOSs) are responsible for producing nitric oxide (NO) from L-arginine. L-arginine is oxidized to produce NO and L-citrulline by NO synthases. Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) are the three NOS isoforms found in mammals. Numerous physiological processes in the nervous, immune, and cardiovascular systems involve NO produced by these various NOS isoforms. Pathologic conditions such as stroke, inflammation, and hypertension can result from uncontrolled NO production. As a result, isoform-specific NOS inhibitors have a lot of potential as therapeutic treatments for diseases linked to NO.

NO Synthase related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Hannokinol V75149 (+)-Hannokinol 408324-76-5 (+)-Hannokinol can be extracted from the fruits of AMOMUM TSAO-KO (Zingiberaceae).
(+)-Rhododendrol ((S)-(+)-Rhododendrol; (+)-Betuligenol) V84404 (+)-Rhododendrol ((S)-(+)-Rhododendrol; (+)-Betuligenol) 59092-94-3
(-)-10,11-Dihydroxyfarnesol V75146 (-)-10,11-Dihydroxyfarnesol 37133-76-9 (-)-10,11-Dihydroxyfarnesol is a compound extracted from the endophytic fungus Cryptomarasmius aucubae.
(2R)-6-Methoxynaringenin V101873 (2R)-6-Methoxynaringenin 1212075-61-0 (2R)-6-methoxynaringenin is the R-form of 6-methoxynaringenin.
(Rac)-Zevaquenabant ((Rac)-MRI-1867) V71565 (Rac)-Zevaquenabant ((Rac)-MRI-1867) 1610420-28-4 (Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a CB1R/iNOS dual-targeting inhibitor (antagonist) with a Ki of 5.7 nM for CB1R.
(Rac)-ZLc-002 V77363 (Rac)-ZLc-002 (Rac)-ZLc-002 is an inhibitor (blocker/antagonist) of the interaction between nNOS and nitric oxide synthase 1 adapter protein (NOS1AP), inhibits inflammatory pain and chemotherapy-induced neuropathic pain, and synergizes with Paclitaxel to reduce tumor cell viability.
(S)-ZLc002 V75092 (S)-ZLc002 308277-46-5 (S)-ZLc002 is the S-enantiomer of ZLc-002.
1,3-PBIT dihydrobromide V102009 1,3-PBIT dihydrobromide 200716-66-1 1,3-PBIT is a potent inhibitor of iNOS with a Ki value of 47 nM, while the Ki values for eNOS and nNOS in purified human enzymes are 9 and 0.25 μM, respectively.
1-Heptadecanoyl-rac-glycerol V90910 1-Heptadecanoyl-rac-glycerol 5638-14-2 1-Heptadecanoyl-rac-glycerol (1-Heptadecanoin) is a glyceride compound with anti-inflammatory activity.
1400W (W1400) V84184 1400W (W1400) 180001-34-7 1400W is a slow, tight binding, highly selective inducible nitric oxide synthase (iNOS) inhibitor
2′-Hydroxy-2,3-dimethoxychalcone V96926 2′-Hydroxy-2,3-dimethoxychalcone 42220-80-4 α-Gracinoic acid is a chalcone derivative with anti-inflammatory activity.
2-苯甲酰氨基-1,4-萘醌 V5303 NQN-1 (PPM-18) 65240-86-0 NQN-1 (PPM-18), a chemically synthesized naphthoquinone derivative and an anti-inflammatory agent, is a novel, potent and cell-permeable and anti-inflammatory agent shown to express inhibitory effects of iNOS through the blocking of NF kappa B activationin vitro.
3,4-DAA V83602 3,4-DAA 2117759-07-4
3-Amino-1,2,4-triazine V75095 3-Amino-1,2,4-triazine 1120-99-6 3-Amino-1,2,4-triazine is a NO synthase inhibitor and can also inhibit the secretion of nitrite.
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid V75119 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 168293-14-9 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid is a triterpenoid with anti~inflammatory activity.
5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether) V75125 5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether) 23050-38-6 5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether) comes from Andrographis paniculata and can inhibit NO with IC50 of 39.1 μM.
6-Methoxynaringenin V75135 6-Methoxynaringenin 94942-49-1 6-Methoxynaringenin is a naturally occurring flavonoid that can inhibit NO production with IC50 of 25.8 μM.
8-Nitroguanine V92174 8-Nitroguanine 168701-80-2 8-Nitroguanine is a product of DNA nitration damage caused by reactive nitrogen species and may be a potential biomarker for the progression of malignant fibrous histiocytoma.
8A8 V75122 8A8 2766594-12-9 8A8 is a potent inhibitor of the pro-inflammatory factor NO with IC50 of 4.7 μM.
9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) V75152 9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) 22333-58-0 9-Hydroxy-α-lapachone (α-DiHydrocaryopterone) is a natural phenol that potently inhibits LPS-induced NO production in RAW 264.7 cells with IC50 of 4.64 µM.
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