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Reactive Oxygen Species

Reactive Oxygen Species

Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.

By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.

Reactive Oxygen Species related products

Structure Cat No. Product Name CAS No. Product Description
Imipramine Blue chloride V102758 Imipramine Blue chloride Imipramine blue chloride is an effective anti-invasive agent.
Isorabaichromone V72919 Isorabaichromone 194669-79-9 Isorabaichromone is an effective antioxidant.
KP372-1 V70198 KP372-1 1374996-60-7 KP372-1 is an Akt inhibitor that can inhibit cancer cell proliferation/growth and cause apoptosis and anoikis.
KS124 V86996 KS124 KS124 (compound 3) is a potent ALDH inhibitor.
Ladanetin-6-O-β-D-glucopyranoside V72961 Ladanetin-6-O-β-D-glucopyranoside 89647-63-2 Ladanetin-6-O-β-D-glucopyranoside is an active flavonoid.
Linocinnamarin V72944 Linocinnamarin 554-87-0 Lincinnamarin is a naturally occurring compound extracted from Fragaria ananassa Duch.
Lipoic acid-d4 V105450 Lipoic acid-d4 1448263-85-1 Lipoic acid-D4 ((R)-(+)-α-lipoic acid-D4) is a deuterated lipoic acid.
LM-021 V88474 LM-021 LM-021 is a coumarin-chalcone derivative with anti-aggregation, antioxidant, neuroprotective and anti-inflammatory properties.
Luciferase-IN-1 V72893 Luciferase-IN-1 10205-56-8 Luciferase-IN-1 is a luciferase inhibitor.
Macarangin V86927 Macarangin 129385-65-5 Macarangin can be isolated from propolis.
Mal-Pc V72914 Mal-Pc 2670367-74-3 Mal-Pc is a multifunctional molecular photosensitizer designed based on phthalocyanine and maleimide.
Manganese(salen) chloride (EUK-8) V72897 Manganese(salen) chloride (EUK-8) 53177-12-1 Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxygen free radical scavenging properties.
MAO-B-IN-7 V70696 MAO-B-IN-7 2851012-65-0 MAO-B-IN-7 is a potent and BBB (blood-brain barrier) permeable (penetrable) inhibitor of MAO-B and AChE, with IC50s of 41 nM, 87 nM and 0.3 μM for human AChE, electric eel AChE and MAO-B, respectively.
MAOS V72923 MAOS 82692-97-5 MAOS is an improved Trinder reagent that could be utilized as a chromogenic probe for the determination of H2O2.
MAPK-IN-3 V104658 MAPK-IN-3 2848599-79-9 MAPK-IN-3 (compound 4a) is an antiproliferative agent and exhibits particularly potent inhibitory effects against KYSE 30, HCT 116, and HGC 27 with IC50 values of 0.57 μM, 3.27 μM, and 2.28 μM, respectively.
Maresin 1 V72890 Maresin 1 1268720-28-0 Maresin 1 is a specific regulatory mediator of endogenous DHA production in the human body and can stimulate intracellular Ca2+ production and secretion.
Maritimetin V72918 Maritimetin 576-02-3 Maritimein is an orange ketone that can be extracted from alyssum.
MCB-613 V1884 MCB-613 1162656-22-5 MCB-613 is a novel and potent stimulator of p160 steroid receptor coactivators (SRCs).
MCI V80716 MCI MCI has a significant anti-inflammatory effect in collagen-induced arthritis (CIA) model by targeting the scavenging of reactive oxygen species (ROS) and down-regulating cyclooxygenase-2 (COX-2).
meso-Zeaxanthin V104196 meso-Zeaxanthin 31272-50-1 Zeaxanthin accumulates in the center of the retina, and together with lutein and zeaxanthin forms the macular pigment, which has a light filtering effect, can inhibit ROS, and exert an antioxidant effect.
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