Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.
By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V102758 | Imipramine Blue chloride | Imipramine blue chloride is an effective anti-invasive agent. | |
|
V72919 | Isorabaichromone | 194669-79-9 | Isorabaichromone is an effective antioxidant. |
|
V70198 | KP372-1 | 1374996-60-7 | KP372-1 is an Akt inhibitor that can inhibit cancer cell proliferation/growth and cause apoptosis and anoikis. |
|
V86996 | KS124 | KS124 (compound 3) is a potent ALDH inhibitor. | |
|
V72961 | Ladanetin-6-O-β-D-glucopyranoside | 89647-63-2 | Ladanetin-6-O-β-D-glucopyranoside is an active flavonoid. |
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V72944 | Linocinnamarin | 554-87-0 | Lincinnamarin is a naturally occurring compound extracted from Fragaria ananassa Duch. |
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V105450 | Lipoic acid-d4 | 1448263-85-1 | Lipoic acid-D4 ((R)-(+)-α-lipoic acid-D4) is a deuterated lipoic acid. |
|
V88474 | LM-021 | LM-021 is a coumarin-chalcone derivative with anti-aggregation, antioxidant, neuroprotective and anti-inflammatory properties. | |
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V72893 | Luciferase-IN-1 | 10205-56-8 | Luciferase-IN-1 is a luciferase inhibitor. |
|
V86927 | Macarangin | 129385-65-5 | Macarangin can be isolated from propolis. |
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V72914 | Mal-Pc | 2670367-74-3 | Mal-Pc is a multifunctional molecular photosensitizer designed based on phthalocyanine and maleimide. |
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V72897 | Manganese(salen) chloride (EUK-8) | 53177-12-1 | Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxygen free radical scavenging properties. |
|
V70696 | MAO-B-IN-7 | 2851012-65-0 | MAO-B-IN-7 is a potent and BBB (blood-brain barrier) permeable (penetrable) inhibitor of MAO-B and AChE, with IC50s of 41 nM, 87 nM and 0.3 μM for human AChE, electric eel AChE and MAO-B, respectively. |
|
V72923 | MAOS | 82692-97-5 | MAOS is an improved Trinder reagent that could be utilized as a chromogenic probe for the determination of H2O2. |
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V104658 | MAPK-IN-3 | 2848599-79-9 | MAPK-IN-3 (compound 4a) is an antiproliferative agent and exhibits particularly potent inhibitory effects against KYSE 30, HCT 116, and HGC 27 with IC50 values of 0.57 μM, 3.27 μM, and 2.28 μM, respectively. |
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V72890 | Maresin 1 | 1268720-28-0 | Maresin 1 is a specific regulatory mediator of endogenous DHA production in the human body and can stimulate intracellular Ca2+ production and secretion. |
|
V72918 | Maritimetin | 576-02-3 | Maritimein is an orange ketone that can be extracted from alyssum. |
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V1884 | MCB-613 | 1162656-22-5 | MCB-613 is a novel and potent stimulator of p160 steroid receptor coactivators (SRCs). |
|
V80716 | MCI | MCI has a significant anti-inflammatory effect in collagen-induced arthritis (CIA) model by targeting the scavenging of reactive oxygen species (ROS) and down-regulating cyclooxygenase-2 (COX-2). | |
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V104196 | meso-Zeaxanthin | 31272-50-1 | Zeaxanthin accumulates in the center of the retina, and together with lutein and zeaxanthin forms the macular pigment, which has a light filtering effect, can inhibit ROS, and exert an antioxidant effect. |
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