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TLR

TLR

A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.

TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.

TLR related products

Structure Cat No. Product Name CAS No. Product Description
FITC-labeled ODN 2395 sodium V79426 FITC-labeled ODN 2395 sodium FITC-labeled ODN 2395 (sodium) is a class C CpG ODN and a TLR9 agonist.
FITC-labeled ODN TTAGGG sodium V79427 FITC-labeled ODN TTAGGG sodium FITC-labeled ODN TTAGGG (sodium) is an inhibitor oligonucleotide that is an antagonist of TLR9, AIM2 and cGAS.
FSL-1 V51032 FSL-1 322455-70-9 FSL-1 is a bacterially derived Toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection.
FSL-1 TFA V79522 FSL-1 TFA FSL-1 TFA is a bacterially derived Toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection.
Ganglioside GD1a V103270 Ganglioside GD1a 12707-58-3 Ganglioside GD1a regulates the toxic and inflammatory effects of Escherichia coli lipopolysaccharide by preventing TLR4 translocation to lipid rafts.
Gardiquimod hydrochloride V102481 Gardiquimod hydrochloride 2956183-81-4 Gardiquimod (hydrochloride) is an imidazoline TLR7/8 agonist.
Guretolimod hydrochloride (DSP-0509 hydrochloride) V76947 Guretolimod hydrochloride (DSP-0509 hydrochloride) Guretolimod HCl is a Toll-like receptor 7 (TLR7) agonist.
HE-S2 V74362 HE-S2 2939851-67-7 HE-S2 is an antibody-drug-conjugate/ADC that triggers potent anti-tumor immune responses.
IMG-2005 V98091 IMG-2005 1229954-79-3 IMG-2005 is a TLR signaling pathway inhibitor that can prevent MyD88 homodimerization by mimicking the Toll/interleukin-1 receptor (TIR) domain, causing airway epithelial cell damage and thus inducing lung immune diseases.
INI-4001 V98113 INI-4001 2549050-07-7 INI-4001 is a TLR7/8 agonist with EC50 values of 1.89 μM and 4.86 μM for TLR7/8, respectively.
JM-9 V85851 JM-9
Lefitolimod (MGN 1703) V51874 Lefitolimod (MGN 1703) 1548439-51-5 Lefitolimod (MGN 1703) is a DNA-based TLR9 agonist and immune surveillance reactivator.
Lefitolimod sodium (MGN 1703 sodium) V80551 Lefitolimod sodium (MGN 1703 sodium) Lefitolimod (MGN 1703) sodium is a DNA-based TLR9 agonist and immune surveillance reactivator.
Lipopolysaccharides, from E. coli K-235 V101393 Lipopolysaccharides, from E. coli K-235 LPS is a lipopolysaccharide endotoxin and TLR-4 activator that activates pathogenicity-associated molecular patterns (PAMPs) of the immune system and induces cells to secrete migrasomes.
Lipopolysaccharides, from E. coli O111:B4 V101180 Lipopolysaccharides, from E. coli O111:B4 LPS is a lipopolysaccharide endotoxin and TLR-4 activator that activates pathogenicity-associated molecular patterns (PAMPs) of the immune system and induces cells to secrete migrasomes.
Lipopolysaccharides, from E. coli O127:B8 V101386 Lipopolysaccharides, from E. coli O127:B8 E. coli O127:B8 LPS is a lipopolysaccharide endotoxin and TLR-4 activator derived from E. coli O127:B8 that activates pathogenicity-associated molecular patterns (PAMPs) of the immune system and induces cell secretion of migrasomes.
Lipopolysaccharides, from E. coli O128:B12 V101383 Lipopolysaccharides, from E. coli O128:B12 Lipopolysaccharide from E. coli O128:B12 is commonly used to stimulate inflammatory pathways in animal models of infection/inflammation-induced preterm birth.
Lipopolysaccharides, from E. coli O26:B6 V87031 Lipopolysaccharides, from E. coli O26:B6 Lipopolysaccharides are lipopolysaccharide endotoxins and TLR-4 activators that activate pathogenicity-associated molecular patterns (PAMPs) of the immune system and induce cell secretion of migratory bodies.
Lipopolysaccharides, from Klebsiella pneumoniae V87030 Lipopolysaccharides, from Klebsiella pneumoniae Lipopolysaccharides are lipopolysaccharide endotoxins and TLR-4 activators that activate pathogenicity-associated molecular patterns (PAMPs) of the immune system and induce cell secretion of migratory bodies.
Lipopolysaccharides, from P. gingivalis V101172 Lipopolysaccharides, from P. gingivalis LPS is a lipopolysaccharide endotoxin and TLR-4 activator that activates pathogenicity-associated molecular patterns (PAMPs) of the immune system and induces cell secretion of migrasomes.
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