A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V74357 | M62812 free base | 613262-61-6 | M62812 (free base) is a toll-like receptor 4 (TLR4) signaling inhibitor. |
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V74351 | Magnesium citrate (Trimagnesium dicitrate) | 3344-18-1 | Magnesium citrate is a form of magnesium salt that effectively penetrates into the brain and muscle tissue. |
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V4032 | MD2-IN-1 | 111797-22-9 | MD2-IN-1, a chalcone derivative, is a novel potent and specific inhibitor ofMyeloid differentiation protein 2(MD2) with potential anti-inflammatory activity. |
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V31431 | MD2-TLR4-IN-1 | 2249801-12-3 | MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 of 0.89 μM and 0.53 μM, respectively. |
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V51766 | MHV-370 | 2205095-75-4 | TLR7/8-IN-1 is an inhibitor of TLR7/TLR8, found in patent WO2019220390, compound 2b. |
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V76757 | MMG-11 quarterhydrate | MMG-11 quarterhydrate is a potent and specific human TLR2 antagonist. | |
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V50923 | Monophosphoryl lipid A (MPLA; Glucopyranosyl lipid A) | 1246298-63-4 | Monophosphoryl lipid A (glucopyranosyl lipid A) is a Toll-like receptor 4 agonist. |
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V1872 | Motolimod (VTX-2337) | 926927-61-9 | Motolimod (also known as VTX-2337;VTX 378; VTX2337) is a novel, selective and potent small molecule agonist of the Toll-like receptor (TLR) 8 with immunostimulating/modulatory and anticancer effects. |
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V80853 | MTvkPABC-P5 | MTvkPABC-P5d, a potent TLR7 agonist/activator, is an immunostimulatory agent. | |
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V83884 | ODN 1018 sodium (1018 ISS sodium) | ||
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V80989 | ODN 105870 sodium | ODN 105870 sodium is a G-modified inhibitory oligonucleotide (INH-ODN), a selective TLR7 inhibitor. | |
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V51779 | ODN 105871 | 1965342-41-9 | ODN 105871 is a G-modified inhibitory oligonucleotide (INH-ODN) and a TLR7 coupling agent. |
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V80990 | ODN 105871 sodium | ODN 105871 sodium is a G-modified inhibitory oligonucleotide (INH-ODN), a selective TLR7 inhibitor. | |
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V84173 | ODN 1826 sodium (CpG 1826 sodium) | ||
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V80991 | ODN 21158 sodium | ODN 21158 sodium is a potent G-modified TLR3 and TLR9 inhibitor. | |
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V80992 | ODN 21595 sodium | ODN 21595 sodium is a guanine-modified inhibitory oligonucleotide (INH-ODN). | |
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V83593 | ODN 2216 sodium | ||
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V74359 | ODN 4084-F | 1934318-44-1 | ODN 4084-F is a class B inhibitory oligonucleotide. |
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V80993 | ODN 4084-F sodium | ODN 4084-F sodium is a Class B inhibitory oligonucleotide. | |
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V74358 | ODN 5328 (ODN 2395 Control) | 500239-51-0 | ODN 5328 (ODN 2395 Control) could be utilized as a control for ODN 2395. |
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