A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V80994 | ODN 5328 sodium (ODN 2395 Control sodium) | ODN 5328 (ODN 2395 Control) sodium could be utilized as a control for ODN 2395. | |
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V74370 | ODN INH 18 | 1934318-43-0 | ODN INH-18 is a linear class B inhibitory oligonucleotide that randomly extends 12 nucleotides after the INH-ODN 4084-F sequence and lacks the ability to form important secondary structures. |
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V80996 | ODN INH 18 sodium | ODN INH-18 sodium is a linear class B inhibitory oligonucleotide that randomly extends 12 nucleotides after the INH-ODN 4084-F sequence and lacks the ability to form important secondary structures. | |
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V74367 | ODN INH-1 | 1934318-42-9 | ODN INH-1 is a palindromic inhibitory oligonucleotide. |
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V80997 | ODN INH-1 sodium | ODN INH-1 sodium is a palindromic inhibitory oligonucleotide. | |
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V74375 | ODN M326 (CpG-ODN M326) | 557124-74-0 | ODN M326 (CpG-ODN M326) is a potent TLR9 agonist. |
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V51778 | ODN-105870 | 1965342-40-8 | ODN 105870 is a G-modified inhibitory oligonucleotide (INH-ODN) and a TLR7 coupling agent. |
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V30447 | Okanin | 484-76-4 | Okanin is the active ingredient in Coreopsis tinctoria. |
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V85317 | ORN 02 | 937769-72-7 | |
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V85314 | ORN 02 sodium | ||
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V85208 | ORN 06 | 1116698-32-8 | |
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V85319 | ORN 06 sodium | ||
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V85655 | Pam2CSK4 TFA | ||
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V74365 | Paridiprubart (NI-0101) | 2641646-59-3 | Paridiprubart (NI-0101) is a humanized anti-TLR4 monoclonal antibody (mAb). |
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V76642 | Pepinh-TRIF TFA | Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TRIF signaling by interfering with TLR-TRIF interaction. | |
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V3939 | PF-4878691 | 532959-63-0 | PF-4878691 (formerly 3M-852A or IMDZQ) is a novel and potent Toll-like receptor 7 (TLR7) agonist modeled so as to dissociate its antiviral activities from its inflammatory activities. |
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V51781 | Polvitolimod | 2389988-81-0 | Polvitolimod is a potent TLR7 agonist/activator utilized in the research into cancer and infectious diseases. |
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V76615 | Poly (I:C):Kanamycin (1:1) | Poly (I:C):Kanamycin (1:1) is a mixture of poly (I:C) and kanamycin. | |
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V76614 | Poly (I:C):Kanamycin (1:1) (sodium) | Poly (I:C):Kanamycin (1:1) sodium is an equal-proportion complex of Poly (I:C) and Kanamycin. | |
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V46737 | Poly:Kanamycin | Poly:Kanamycinis a mixture of poly (I:C) and kanamycin. |
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