A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V103640 | Monophosphoryl Lipid A-12 free acid | 88598-53-2 | Monophosphoryl lipid A-12 (free acid) is a Toll-like receptor 4 agonist. |
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V97686 | MTT5 | MTT5 is a Toll-like receptor 7 (TLR7) agonist. | |
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V80853 | MTvkPABC-P5 | 3027976-10-6 | MTvkPABC-P5d, a potent TLR7 agonist/activator, is an immunostimulatory agent. |
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V83884 | ODN 1018 sodium (1018 ISS sodium) | ||
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V80989 | ODN 105870 sodium | ODN 105870 sodium is a G-modified inhibitory oligonucleotide (INH-ODN), a selective TLR7 inhibitor. | |
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V51779 | ODN 105871 | 1965342-41-9 | ODN 105871 is a G-modified inhibitory oligonucleotide (INH-ODN) and a TLR7 coupling agent. |
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V80990 | ODN 105871 sodium | ODN 105871 sodium is a G-modified inhibitory oligonucleotide (INH-ODN), a selective TLR7 inhibitor. | |
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V87018 | ODN 1668 sodium | ODN 1668 sodium is a class B CpG ODN (oligodeoxynucleotide) and a TLR-9 agonist. | |
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V84173 | ODN 1826 sodium (CpG 1826 sodium) | ||
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V90331 | ODN 2007 sodium | ODN 2007 sodium is a class B CpG ODN (oligodeoxynucleotide) and a Toll-like receptor (TLR) ligand. | |
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V87023 | ODN 20844 sodium | ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is an inhibitor of TLR7 and TLR9 (Toll-like receptor), and its parent is INH-ODN 2088. | |
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V87022 | ODN 2088 sodium | ODN 2088 sodium is a potent inhibitor of TLR3, TLR7 and TLR9. | |
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V80991 | ODN 21158 sodium | ODN 21158 sodium is a potent G-modified TLR3 and TLR9 inhibitor. | |
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V80992 | ODN 21595 sodium | ODN 21595 sodium is a guanine-modified inhibitory oligonucleotide (INH-ODN). | |
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V83593 | ODN 2216 sodium | ||
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V87035 | ODN 2336 sodium | ODN 2336 sodium is a class A CpG ODN (oligodeoxynucleotide) and is a potent TLR9 agonist. | |
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V87017 | ODN 2395 sodium | ODN 2395 sodium is a class C oligonucleotide that can be used as a vaccine adjuvant. | |
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V87027 | ODN 24888 sodium | ODN 24888 sodium is a guanine-modified inhibitory oligonucleotide (INH-ODN) that exhibits strong inhibitory effects on TLR7/TLR9-mediated signaling pathways. | |
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V98483 | ODN 24987 sodium | ODN 24987 sodium is a guanine-modified inhibitory oligonucleotide (ODN) targeting TLR9. | |
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V90334 | ODN 24991 sodium | ODN 24991, a guanine-modified inhibitory oligonucleotide (INH-ODN), is an inhibitor of TLR3, TLR7 and TLR9 (Toll-like receptor), and its parent is INH-ODN 2088. |
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