A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74353 | polyinosinic acid | 30918-54-8 | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. |
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V83625 | Polyinosinic acid sodium | 33378-44-8 | |
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V50915 | Polyinosinic-polycytidylic acid | 24939-03-5 | Polyinosinic acid (Poly(I:C)), a synthetic analog of double-stranded RNA, is a TLR-3 agonist. |
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V37712 | Polyinosinic-polycytidylic acid sodium | 42424-50-0 | Polyinosinic-polycytidylic acid sodium(Poly(I:C) sodium)is an analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors with the potential to be usedas a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. |
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V74347 | PSMα3 | 1001405-52-2 | PSMα3 is a bioactive peptide for induction of tolerogenic DCs and may be used in DC vaccination. |
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V4598 | Resatorvid | 243984-11-4 | Resatorvid (formerly also known as TAK-242) is a novel,cell-permeable and potentTLR4 (Toll-Like Receptor)signaling inhibitor with immunomodulatory and anti-inflammatory activity. |
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V1867 | Resiquimod (R848) | 144875-48-9 | Resiquimod(formerly known as R-848; S-28463; VML-600;R848, S27609)is a potent imidazoquinolinamine-based immune response modifier that acts as an agonist of the TLR 7/8 receptors (Toll-like receptor 7/8) withantiviral and antitumour activity. |
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V76547 | RS 09 TFA | RS 09 TFA is a TLR4 agonist. | |
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V51780 | Ruzotolimod | 1948241-60-8 | Ruzotolimod is a TLR7 agonist. |
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V5940 | Schaftoside | 51938-32-0 | Schaftoside is a flavonoid found in many Chinese herbal medicines, like Eleusine indica. |
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V5846 | SM-324405 | 677773-91-0 | SM-324405 (SM324405; SM 324405) is a novel and potent TLR7 (toll-like receptor 7) agonist designed by introducing the antedrug concept with reduced systemic activity. |
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V85349 | ssRNA40 sodium | ||
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V85338 | ssRNA41 sodium | ||
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V85342 | ssRNA42 sodium | ||
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V74348 | Stepharine | 2810-21-1 | Stepharine is a naturally occurring alkaloid that directly targets TLR4 (TLR4 inhibitor) and binds to the TLR4/MD2 complex. |
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V74339 | Sulfo-ara-F-NMN (CZ-48) | 1374663-29-2 | Sulfo-ara-F-NMN (CZ-48) is an analog of nicotinamide mononucleotide (NMN). |
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V81521 | TAT-CIRP | TAT-CIRP is a small peptide that refers to the trans-transactivating (Tat) cold-inducible RNA-binding protein. | |
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V74369 | Tilsotolimod | 1948266-37-2 | Tilsotolimod is a TLR9 agonist that has shown anti-tumor effects in preclinical models. |
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V74363 | Tilsotolimod sodium | 2089768-67-0 | Tilsotolimod is a TLR9 agonist that has shown anti-tumor effects in preclinical models. |
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V16506 | TLR2-IN-C29 (C29 ) | 363600-92-4 | TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. |
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