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TLR

TLR

A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.

TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.

TLR related products

Structure Cat No. Product Name CAS No. Product Description
TLR7/8 agonist 7 V51768 TLR7/8 agonist 7 2567953-47-1 TLR7/8 agonist 7 (compound 10) is a TLR7/8 agonist.
TLR7/8 agonist 8 V51774 TLR7/8 agonist 8 2649170-16-9 TLR7/8 Agonist 8 (Compound 24m) is a potent Toll-like receptor 7/8 (TLR7/8) dual agonist/activator with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively.
TLR7/8 agonist 9 V51770 TLR7/8 agonist 9 2649170-17-0 TLR7/8 agonist 9 (Compound 25a) is a TLR7/8 agonist/activator with EC50 of 40 nM and 23 nM for hTLR7/8.
TLR7/8 agonist-5d V16508 TLR7/8 agonist-5d 1620278-72-9 TLR7/8 agonist 1 diHCl is a dual agonist of the toll-like receptor TLR7/TLR8.
TLR7/8 Antagonist 1 V51772 TLR7/8 Antagonist 1 2901020-63-9 TLR7/8 Antagonist 1 (Compound 16c) is a potent antagonist of TLR7/8 with IC50s of 3.91 and 2.19 μM respectively.
TLR7/8 antagonist 2 V51769 TLR7/8 antagonist 2 2769085-03-0 TLR7/8 Antagonist 2 (Compound 15) is a potent, interface-active TLR7/8 agonist/activator with IC50s of 4.9 and 0.6 nM, respectively.
TLR7/8/9 antagonist 2 V51771 TLR7/8/9 antagonist 2 2920729-91-3 TLR7/8/9 Antagonist 2 is a TLR7/8/9 antagonist (inhibitor) with cutoff activity.
TLR7/8/9-IN-1 V51773 TLR7/8/9-IN-1 2180127-82-4 TLR7/8/9-IN-1 is an orally bioavailable small molecule antagonist of Toll-like receptor 7/8/9 (TLR7/8/9) (IC50 = 43 nM).
TLR7agonist 15 V74361 TLR7agonist 15 2832199-53-6 TLR7 agonist 15 (compound 16b) is a potent TLR7 agonist/activator with EC50 of 59 nM.
TLR8 agonist 2 V51786 TLR8 agonist 2 2412937-64-3 TLR8 Agonist 2 is a potent and specific TLR8 agonist/activator with EC50 of 3nM for human TLR8.
TLR8 agonist 2 hydrochloride V51785 TLR8 agonist 2 hydrochloride 2412937-65-4 TLR8 Agonist 2 HCl is a potent and specific TLR8 agonist/activator with EC50 of 3 nM for human TLR8.
TLR8 agonist 5 V74346 TLR8 agonist 5 2413016-41-6 TLR8 agonist 5 is a potent TLR8 agonist/activator with EC50 of 20 nM for HEK-Blue hTLR8.
TLR8 agonist 6 V74371 TLR8 agonist 6 2616605-55-9 TLR8 agonist 6 (Compound A) is a TLR8 agonist/activator with EC50 of 0.052 μM.
TMX-201 V51782 TMX-201 1149339-78-5 TMX-201 is a TLR7 ligand-phospholipid co-enhancer.
Tomarilimab (OPN-305) V74349 Tomarilimab (OPN-305) 1449294-76-1 Tomarlimab (OPN-305) is a humanized anti-TLR2 (anti-TLR2) IgG4 monoclonal antibody (mAb).
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH V81611 Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH is a linker containing the TLR4 inhibitor TLR4-IN-C34.
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH V81612 Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a linker containing the TLR4 inhibitor TLR4-IN-C34.
Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH V81613 Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH is a linker containing the TLR4 inhibitor TLR4-IN-C34.
Vesatolimod (GS-9620) V1860 Vesatolimod (GS-9620) 1228585-88-3 Vesatolimod (formerly known as GS9620; GS-9620)is a novel potent, selective and orally bioactive small molecule agonist of Toll-like receptor 7 (TLR-7) with antiviral activity.
Vidutolimod (CMP-001) V74374 Vidutolimod (CMP-001) 147063-80-7 Vidutolimod is a CpG-A class oligonucleotide and a TLR9 agonist.
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