Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct families of carbonic anhydrase enzymes (CAs) have so far been identified. Numerous physiological and pathological processes involve carbonic anhydrases. Many of them have the potential to be inhibited as effective therapeutic targets for the treatment of a variety of diseases, including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.
The carbonic anhydrase reaction is involved in a variety of physiological and pathological processes, including bone resorption, calcification, tumorigenicity, pH and CO2 homeostasis, electrolyte secretion in various tissues and organs, and respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs. Zn2+ metalloproteins known as -CAs are found in a wide range of organisms, including plants, prokaryotes, fungi, algae, and protozoa. Numerous diseases, including glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc., have been linked to sixteen mammalian -CA isoforms.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73766 | CAIX/CAXII-IN-1 | 2439165-37-2 | Compound 9 was most potent against tumor-specific CA IX/CA XII (KI=29.1 and 8.8 nM), making it possible to evaluate its cytotoxic effect and selectivity against HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro , and its IC50s against tumor cells are 1.78, 1.94 and 3.07μM respectively, indicating that it has obvious cytotoxic effect. |
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V87337 | CAIX/CAXII-IN-2 | CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor with Ki values of 8.9 nM and 5.3 nM for CAIX/CAXII, respectively. | |
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V94840 | CAIX/CAXII-IN-3 | CAIX/CAXII-IN-3 (Compound 11) is an inhibitor of CAIX/CAXII with IC50 value less than 65 nM. | |
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V73747 | Carbonic anhydrase (carbonic anhydrase; EC 4.2.1.1) | 9001-03-0 | Carbonic anhydrases are ubiquitous zinc-containing metalloenzymes in prokaryotes and eukaryotes. |
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V73763 | Carbonic anhydrase inhibitor 12 | 2883451-38-3 | Carbonic anhydrase inhibitor 12 is a potent inhibitor of CA II and also exhibits inhibitory effect against CA I (Kis of CA II and CA I are 1.72 nM and 271 nM, respectively). |
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V78640 | Carbonic anhydrase inhibitor 15 | Carbonic anhydrase inhibitor 15 (Compound 8) is a carbonic anhydrase inhibitor (Ki: 8.5 nM for hCA II). | |
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V84284 | Carbonic anhydrase inhibitor 16 | 4479-70-3 | |
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V84313 | Carbonic anhydrase inhibitor 17 | 3033849-05-4 | |
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V83907 | Carbonic anhydrase inhibitor 18 | ||
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V83724 | Carbonic anhydrase inhibitor 19 | ||
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V73759 | Carbonic anhydrase inhibitor 2 | 2758231-43-3 | Carbonic anhydrase inhibitor 2 (compound 7c) is a carbonic anhydrase II (carbonic anhydrase II) inhibitor that can reduce intraocular pressure in glaucoma rabbits. |
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V87333 | Carbonic anhydrase inhibitor 20 | Carbonic anhydrase inhibitor 20 (compound 11) is a piperazine sulfonamide carbonic anhydrase inhibitor. | |
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V87329 | Carbonic anhydrase inhibitor 21 | Carbonic anhydrase inhibitor 21 (Compound 5h) is a selective carbonic anhydrase (hCA IX) inhibitor, with a Ki of 15.1 nM, and is highly selective against other investigated isoform. | |
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V87349 | Carbonic anhydrase inhibitor 22 | 146533-50-8 | Carbonic anhydrase inhibitor 22 (Compd 2g) is a sulfonamide carbonic anhydrase inhibitor with Ki values of 762 nM (hCA I), 20.3 nM (hCA II), 8.3 nM (hCA VII), 17.9 nM (hCA IX) and 10.5 nM (hCA XII). |
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V87345 | Carbonic anhydrase inhibitor 23 | Carbonic anhydrase inhibitor 23 (compound 40) is a potent carbonic anhydrase (CA) inhibitor with Ki values of 617.2 nM and 434.1 nM for hCA I (α) and hCA II (α), respectively. | |
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V87338 | Carbonic anhydrase inhibitor 24 | Carbonic anhydrase inhibitor 24 (Compound 11) is a human carbonic anhydrase inhibitor. | |
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V87347 | Carbonic anhydrase inhibitor 25 | Carbonic anhydrase inhibitor 25 (compound 6a) is a potent carbonic anhydrase inhibitor. | |
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V94542 | Carbonic anhydrase inhibitor 26 | Carbonic anhydrase inhibitor 26 (Compound 6T) is a carbonic anhydrase II inhibitor with IC50 of 9.10 ± 0.26 μM. | |
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V73767 | Carbonic anhydrase inhibitor 3 | 2758231-56-8 | Carbonic anhydrase inhibitor 3 (compound 11g) is a carbonic anhydrase II (carbonic anhydrase II) inhibitor that can reduce intraocular pressure in glaucoma rabbits. |
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V73754 | Carbonic anhydrase inhibitor 4 | 2764889-93-0 | Carbonic anhydrase inhibitor 4 is a light probe/inhibitor of carbonic anhydrase. |
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