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Carbonic Anhydrase

Carbonic Anhydrase

Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct families of carbonic anhydrase enzymes (CAs) have so far been identified. Numerous physiological and pathological processes involve carbonic anhydrases. Many of them have the potential to be inhibited as effective therapeutic targets for the treatment of a variety of diseases, including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.

The carbonic anhydrase reaction is involved in a variety of physiological and pathological processes, including bone resorption, calcification, tumorigenicity, pH and CO2 homeostasis, electrolyte secretion in various tissues and organs, and respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs. Zn2+ metalloproteins known as -CAs are found in a wide range of organisms, including plants, prokaryotes, fungi, algae, and protozoa. Numerous diseases, including glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc., have been linked to sixteen mammalian -CA isoforms.

Carbonic Anhydrase related products

Structure Cat No. Product Name CAS No. Product Description
Chloraminophenamide V106705 Chloraminophenamide 121-30-2 Chloroaminobenzidine (Compound 14) is a carbonic anhydrase inhibitor with Ki values of 75, 160, and 8400 nM for hCA II, bCA IV, and hCA I, respectively.
Chlorthalidone Impurity G V94160 Chlorthalidone Impurity G 16289-13-7 Chlorthalidone Impurity G (Chlorthalidone EP Impurity G) is a potential impurity found in commercial formulations of chlorthalidone with moderate antihypertensive activity.
Chlorzolamide V105338 Chlorzolamide 5541-92-4 Chlorzolamide (CL 13580) is a carbonic anhydrase (CA) inhibitor.
FC14-584B V85056 FC14-584B 1358567-64-2
hCA I-IN-3 V87332 hCA I-IN-3 hCA I-IN-3 (compound 24) is an aryl ether derivative and a potent carbonic anhydrase inhibitor.
hCA I-IN-4 V104898 hCA I-IN-4 3054159-56-4 hCA I-IN-4 (Compound 14) is an inhibitor of carbonic anhydrase and cholinesterase, and can inhibit hCA I, hCA II, AChE, and BChE with Ki of 29.94 nM, 17.72 nM, 21.21 nM, and 7.65 nM, respectively.
hCA IX-IN-2 V79712 hCA IX-IN-2 hCA IX-IN-2 is a potent and specific inhibitor of hCA IX with a KI of 32.1 nM.
hCA XII-IN-6 V80292 hCA XII-IN-6 hCA XII-IN-6 (compound 4d) is a potent hCA XII inhibitor (antagonist) with Ki of 84.2 nM.
hCA/VEGFR-2-IN-1 V79713 hCA/VEGFR-2-IN-1 hCA/VEGFR-2-IN-1 is a potent bicarbonic anhydrase (CA) IX/XII with Kis of 4.7 nM and 8.3 nM for hCA XII and hCA IX, respectively.
hCAI/II-IN-10 V105427 hCAI/II-IN-10 hCAI/II-IN-10 (compound 5d) is an inhibitor of human carbonic anhydrase I and II (hCA I and hCA II) with IC50 values of 4.32 and 3.89 nM, respectively.
hCAI/II-IN-6 V73748 hCAI/II-IN-6 694466-00-7 hCAI/II-IN-6 is an orally bioactive human carbonic anhydrase (CA) inhibitor.
hCAI/II-IN-7 V86013 hCAI/II-IN-7 14204-32-1
hCAI/II/XII-IN-1 V107032 hCAI/II/XII-IN-1 100142-87-8 hCAI/II/XII-IN-1 (Compound 7) is a human carbonic anhydrase hCAI/II/XII inhibitor with Ki values of 78.5, 9.1, 605, 7.7, 3.7 nM.
hCAII-IN-10 V83525 hCAII-IN-10
hCAII-IN-3 V73764 hCAII-IN-3 2770927-76-7 hCAII-IN-3 (Compound 16) is a human carbonic anhydrase (hCA) inhibitor (antagonist) with Kis of 403.8, 5.1, 10.2, and 5.2 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively.
hCAII-IN-4 V73761 hCAII-IN-4 2816080-18-7 hCAII-IN-4 (Compound 12j) is a potent hCA II inhibitor (antagonist) with IC50 of 7.78 μM.
hCAII-IN-5 V73762 hCAII-IN-5 2816080-16-5 hCAII-IN-5 (compound 12h) is a potent and specific inhibitor of human carbonic anhydrase II (hCA II) with IC50 of 4.55 μM.
hCAII/IX-IN-1 V104557 hCAII/IX-IN-1 hCAII/IX-IN-1 (compound 4o) is a potent inhibitor of hCAII and hCAIX with Ki values of 7.4 and 7.0 nM, respectively.
hCAII/XII-IN-1 V104558 hCAII/XII-IN-1 hCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII with Ki values of 8.4 and 9.4 nM, respectively.
HCAIX-IN-1 V73757 HCAIX-IN-1 2389034-65-3 HCAIX-IN-1 (compound 21e) is a potent and specific HCAIX inhibitor (antagonist) with Kis of 694.9, 126.6, 3.3, and 9.8 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively.
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