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Cathepsin

Cathepsin

Cathepsins are protease enzymes that can be divided into several families. Cathepsins come in serine, cysteine, or aspartyl protease varieties. Humans have cathepsins from about 15 different classes (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins perform a variety of tasks and are active in the lysosome's low pH environment. Similar to other enzymes, they are essential for a variety of physiological processes, including apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, metastasis, digestion, blood clotting, bone resorption, ion channel activity, innate immunity, complement activation, and a host of others.

Numerous pathologies, such as arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola, have been linked to the dysregulated cathepsins.

Cathepsin related products

Structure Cat No. Product Name CAS No. Product Description
3-表熊果酸 V28590 3-Epiursolic Acid 989-30-0 3-Epiursolic Acid is a triterpenoid that can be extracted from Eriobotrya japonica.
Arg-Arg-AMC acetate V87355 Arg-Arg-AMC acetate Arg-Arg-AMC acetate is the acetate form of Arg-Arg-AMC.
Bz-FVR-AMC TFA V87360 Bz-FVR-AMC TFA Bz-FVR-AMC TFA is a fluorescent substrate for cathepsin with a kcat/Km value of 1070 mM-1s-1. High concentrations of BZ-FVR-AMC have an inhibitory effect on the substrate.
Cathepsin C-IN-6 V78655 Cathepsin C-IN-6 Cathepsin C-IN-6 (compound 2) is an E-64c-hydrazine-based cathepsin C (cathepsin C) inhibitor (antagonist) with anti-inflammatory activity.
Cathepsin D and E FRET Substrate acetate V77164 Cathepsin D and E FRET Substrate acetate Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsin D and E, not for B, H or I, and its cleavage occurs at the Phe-Phe amide bond.
Cathepsin D/E Substrate, Fluorogenic V78656 Cathepsin D/E Substrate, Fluorogenic Cathepsin D/E Substrate, Fluorogenic, an 11-amino acid (AA) peptide, is a selective substrate for cathepsins D and E.
Cathepsin G V85302 Cathepsin G 107200-92-0
Cathepsin H, human liver V83635 Cathepsin H, human liver 60748-73-4
Cathepsin Inhibitor 3 V78657 Cathepsin Inhibitor 3 3026372-49-3 Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in the radiosynthesis of compound [18F]2k and is selective for cathepsin S.
Cathepsin Inhibitor 4 V87359 Cathepsin Inhibitor 4 Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S with Ki of 0.04 nM.
Cathepsin K inhibitor 4 V77985 Cathepsin K inhibitor 4 Cathepsin K inhibitor 4 is a potent carbohydrazide cathepsin K inhibitor, with IC50s of 13 nM, 269 nM, and 296 nM for human, rat, and mouse cathepsin K respectively.
Cathepsin K inhibitor 7 V101025 Cathepsin K inhibitor 7 Cathepsin K inhibitor 7 (Compound 7) is a Cathepsin K inhibitor with a pKi value of 7.3 for CatK.
Cathepsin L-IN-3 V86253 Cathepsin L-IN-3 478164-48-6
Cathepsin L-IN-4 (1-Naphthalenesulfonyl-Ile-Trp-CHO) V85549 Cathepsin L-IN-4 (1-Naphthalenesulfonyl-Ile-Trp-CHO) 161709-56-4
Cathepsin L/S-IN-1 V78658 Cathepsin L/S-IN-1 Cathepsin L/S-IN-1 is a dual (bifunctional) inhibitor of Cathepsin L and Cathepsin S with IC50 of 4.10 μM and 1.79 μM respectively.
CTSC-IN-1 V93268 CTSC-IN-1 CTSC-IN-1 (B22) is a CTSC inhibitor.
CTSL/CAPN1-IN-1 V87358 CTSL/CAPN1-IN-1 CTSL/CAPN1-IN-1 (compound 14a) is an orally active CTSL and CAPN1 inhibitor with IC50 values of 3.34 nM and 375.1 nM, respectively.
CTSL/CAPN1-IN-2 V87357 CTSL/CAPN1-IN-2 2410075-64-6 CTSL/CAPN1-IN-2 (Compound 14b) is an orally active CTSL and CAPN1 inhibitor with IC50 values of 6.88 nM and 347.6 nM, respectively.
Dutacatib V88344 Dutacatib 501000-36-8 Dutacatib is an inhibitor of SARS-CoV-2 3CLpro and cathepsin K, has antiviral activity, and can improve cancer-induced bone disease.
E-64 HCl V3413 E-64 HCl E-64 HCl, the hydrochloride salt form of E-64, which isisolated from cultures of Aspergillus, is anovel, potent,irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.
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