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Ceramidase

Ceramidase

Ceramidases are a group of enzymes that catalyze the hydrolysis of ceramide, dihydroceramide, and phytoceramide into sphingosine (SPH), dihydrosphingosine (DHS), and phytosphingosine (PHS), respectively, along with a free fatty acid.Ceramidases, which play a crucial role in the pathophysiology of diseases with altered lipid homeostasis like Alzheimer's disease, type 2 diabetes-induced insulin resistance, cancer, and cardiovascular conditions, regulate the breakdown of ceramides. According to the pH ideal for their catalytic activity, ceramidases are divided into the acid, neutral, and alkaline ceramidase subtypes.

Ceramidase related products

Structure Cat No. Product Name CAS No. Product Description
Z-Leu-Tyr-Chloromethylketone V73039 Z-Leu-Tyr-Chloromethylketone 56979-35-2 Z-Leu-Tyr-Chloromethylketone is a calpain
Z-Phe-Arg-pNA V73050 Z-Phe-Arg-pNA 117761-01-0 Z-Phe-Arg-pNA is a substrate of cathepsin L.
Z-Phe-Phe-Diazomethylketone V73059 Z-Phe-Phe-Diazomethylketone 65178-14-5 Z-Phe-Phe-Diazomethylketone is a specific inhibitor of cathepsin L.
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