Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73957 | 7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) | 220001-53-6 | 7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. |
|
V73961 | 7-Ethoxyresorufin (7-ethoxyresorufin; Resorufin ethyl ether) | 5725-91-7 | 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorescent substrate and competitive inhibitor of cytochrome P450 (especially CYP1A1). |
|
V70676 | 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate | 67667-71-4 | 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor (antagonist) with IC50 of 8.64 μM and 22.3 μM for preincubation and co-incubation, respectively. |
|
V73946 | Abiraterone-d4 (CB-7598-d4) | 2122245-62-7 | Abiraterone-d4 is the deuterated form of Abiraterone. |
|
V77872 | Anticancer agent 111 | Anticancer agent 111 (compound 11) is a potent cytochrome P450 inhibitor (antagonist) with IC50 of 3 μM for CYP3A4. | |
|
V73967 | Antitumor agent-87 | 1422527-88-5 | Antitumor agent-87 is a potent antitumor agent. |
|
V73965 | Antitumor agent-88 | 1422527-87-4 | Antitumor agent-88 displays potent antimitotic activity and arrests cells in the G2/M phase. |
|
V84866 | Aromatase-IN-3 | ||
|
V69162 | AS1810722 | 909561-15-5 | AS1810722 is an orally bioactive STAT6 inhibitor (antagonist) with IC50 of 1.9 nM. |
|
V70250 | Aschantin | 13060-15-6 | Aschantin is a diepoxy lignan that can be extracted from magnolia. |
|
V73980 | Azamulin | 76530-44-4 | Azamulin is an irreversible, selective inhibitor of human CYP3Aa. |
|
V7346 | Bergaptol | 486-60-2 | Bergaptol is an inhibitor (blocker/antagonist) of debenzylation of the CYP3A4 enzyme with IC50 of 24.92 μM. |
|
V5064 | Brassinazole | 224047-41-0 | Brassinazole is a novel and potentinhibitor of brassinosteroid biosynthesis. |
|
V73952 | Bromobenzene-d5 (pentadeuterobromobenzene) | 4165-57-5 | Bromobenzene-d5 is the deuterated form of bromobenzene. |
|
V73935 | CAY 10434 | 769917-29-5 | CAY 10434 is a potent CYP4A hydroxylase inhibitor. |
|
V73926 | Chalepensin | 13164-03-9 | Chalepensin is a furanocoumarin and a competitive CYP2A6 inhibitor. |
|
V73951 | Chlorzoxazone-13C (Chlorzoxazone-13C) | 616865-28-2 | Chlorzoxazone-13C is 13C (carbon 13)-labeled Chlorzoxazone. |
|
V73929 | Chlorzoxazone-d3 (Chlorzoxazone-d3) | 1185173-60-7 | Chlorzoxazone-d3 is the deuterated form of Chlorzoxazone. |
|
V73956 | Cholesterol 24-hydroxylase-IN-2 | 1613481-52-9 | Cholesterol 24-Hydroxylase-IN-2 is an inhibitor (blocker/antagonist) of cholesterol 24-hydroxylase (CH24H or CYP46A1) with IC50 of 5.4 nM. |
|
V29952 | Chrysosplenetin | 603-56-5 | Chrysosplenetin is one of the polymethoxylated flavonoids found in Artemisia annua and several other Chinese herbal medicines. |
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