Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis.The DPP-IV family of dipeptidyl peptidases, which also includes DPP-7, DPP-8, DPP-9, fibroblast activation protein, and others, cleaves the peptide bond after the penultimate proline residue and has a large number of drug targets.
A serine protease known as DPP-IV (DPP4 or CD26) has been found on a number of immune cells and epithelial cells from different organs. A catalytically active soluble form of the enzyme is also found in several bodily fluids in addition to the membrane-bound enzyme. The N-termini of numerous chemokines, neuropeptides, and hormones are cleaved off by both variants, releasing dipeptides. By focusing on various substrates, DPP IV is essential for the regulation of the immune system, inflammation, oxidative stress, cell adhesion, and apoptosis. Drugs that inhibit DPP IV are frequently used to lower blood sugar.
DPP8 and DPP9 exhibit DPPIV-like activity and have a high degree of sequence similarity. Intracellular N-terminal dipeptidyl peptidases DPP8 and DPP9 (preferentially postproline) have been linked to pathophysiological roles in cancer biology and immune response.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73075 | Fotagliptin (SAL067 free base) | 1312954-58-7 | Fotagliptin is a dipeptidyl peptidase IV (DPP-4) inhibitor (IC50=2.27 nM). |
|
V73072 | Fotagliptin benzoate (SAL067) | 1403496-40-1 | Fotagliptin benzoate is a dipeptidyl peptidase IV (DPP-4) inhibitor (IC50=2.27 nM). |
|
V73070 | Gemigliptin tartrate (LC15-0444 tartrate) | 1374639-74-3 | Gemigliptin tartrate (LC15-0444 tartrate) is a selective, reversible, competitive dipeptidyl peptidase 4 (DPP-4) inhibitor (antagonist) with IC50 of 10.3 nM for human recombinant DPP-4. |
|
V84286 | Gly-Pro-pNA hydrochloride | 103213-34-9 | |
|
V105603 | H-Gly-Pro-Hyp-OH acetate | 103192-50-3 | H-Gly-Pro-Hyp-OH acetate is a dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50 of 2.51 mM. |
|
V73081 | Lys-Ala-pNA | 115846-24-7 | Lys-Ala-pNA is a hydrolytic substrate for dipeptidyl peptidase (DPP) II with a Km of 0.42 mM. |
|
V102981 | N-Boc-Sitagliptin | 486460-23-5 | N-Boc-sitagliptin is a synthetic intermediate of the dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin. |
|
V73078 | NVP-DPP728 dihydrochloride | 207556-62-5 | NVP-DPP728 di-HCl is a potent and specific inhibitor of dipeptidyl peptidase IV (DPP-IV) with a Ki of 11 nM. |
|
V87375 | NZ-97 | NZ-97 is an inhibitor of dipeptidyl peptidase 4 (DPP4) with an IC50 of 18 nM. | |
|
V73077 | O-Benzoylhydroxylamine | 54495-98-6 | O-Benzoyloxyamine is a DPP-IV inhibitor (antagonist) with anti-diabetic effects (WO2006034435A2). |
|
V73080 | P32/98 | 136259-20-6 | P32/98 is a dipeptidyl peptidase IV (DPP4) inhibitor. |
|
V102476 | PK44 | 1017682-65-3 | PK44 (Compound 67) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with IC50 of 15.8 nM. |
|
V87377 | SGP8 | 855790-98-6 | SGP8 (IAVPGEVA) is an octapeptide produced by hydrolysis of soybean 11 S globulin, which has the effects of regulating lipid metabolism, inflammation and fibrosis. |
|
V73073 | Sheng Gelieting (CGT-8012) | 1152810-23-5 | Sheng Gelieting (CGT-8012) is a dipeptidyl peptidase-IV enzyme (DP-IV) inhibitor. |
|
V73074 | Sitagliptin fenilalanil hydrochloride | 1339954-75-4 | Sitagliptin fenilalanil HCl is a dipeptide aminopeptidase (DPP-4) inhibitor. |
|
V76456 | Talabostat isomer mesylate | Talabostat isomer mesylate is an isomer of talabostat mesylate. | |
|
V4579 | UAMC-00039 dihydrochloride | 697797-51-6 | UAMC00039 dihydrochloride is a novel, potent, reversible and competitivedipeptidyl peptidase II(DPP-II) inhibitor with anIC50of 0.48 nM. |
|
V106264 | VAMP | VAMP, a tetrapeptide, is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor with IC50 of 1.00 μM and Kd of 6.89 μM. | |
|
V87376 | ZINC000003015356 | 872861-28-4 | ZINC000003015356 is a DPP4 inhibitor. |
|
V73068 | γ-Glu-Tyr | 7432-23-7 | γ-Glu-Tyr is a competitive inhibitor (IC50=6.77 mM) of dipeptidyl peptidase-IV (DPP-IV) and a potential functional ingredient in type 2 diabetes diets. |
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